Science | Nature | Cell | View More
Natural Products
Volvaltrate B
Volvaltrate B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Volvaltrate B
Price:
CAS No.: 1181224-13-4
Catalog No.: CFN96443
Molecular Formula: C27H41ClO11
Molecular Weight: 577.06 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Powder
Source: The herbs of Valeriana jatamansi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Melbourne (Australia)
  • Osmania University (India)
  • University of Mysore (India)
  • University of Auckland (New Zealand)
  • Universidade do Porto (Portugal)
  • University of Zurich (Switzerland)
  • Universidade Federal de Goias (... (Brazil)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Copenhagen University (Denmark)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
Package
Featured Products
Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Isocorynoxeine

Catalog No: CFN98155
CAS No: 51014-29-0
Price: $128/20mg
Proline

Catalog No: CFN99612
CAS No: 147-85-3
Price: $30/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Morin

Catalog No: CFN99929
CAS No: 480-16-0
Price: $30/20mg
Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg
Notoginsenoside R4

Catalog No: CFN91142
CAS No: 87741-77-3
Price: $238/5mg
Praeruptorin B

Catalog No: CFN98140
CAS No: 81740-07-0
Price: $100/20mg
Alantolactone

Catalog No: CFN99934
CAS No: 546-43-0
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, respectively.
In vitro:
J Nat Prod. 2010 Oct 22;73(10):1723-6.
Revision of the Structures of 1,5-Dihydroxy-3,8-epoxyvalechlorine, Volvaltrate B, and Valeriotetrate C from Valeriana jatamansi and V. officinalis.[Pubmed: 20853876 ]

METHODS AND RESULTS:
The structures of 1,5-dihydroxy-3,8-epoxyvalechlorine (1a) and Volvaltrate B (6a), two new chlorinated iridoids isolated from Valeriana jatamansi and V. officinalis, respectively, were originally assigned on the basis of spectroscopic methods. Reinvestigation using X-ray analysis and chemical transformation revealed that the original assignment of H-7 in 1a and OH-8 in 6a should be inverted and that the structures should be revised to 1 and 6, respectively. Correspondingly, the structure of valeriotetrate C (7a) should be revised to 7.
CONCLUSIONS:
Volvaltrate B (6) showed cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 μM, respectively.
Volvaltrate B Description
Source: The herbs of Valeriana jatamansi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Asiaticoside B

Catalog No: CFN95124
CAS No: 125265-68-1
Price: $158/20mg
2,6-Dihydroxyacetophenone-4-O-[4',...

Catalog No: CFN95470
CAS No: 1781226-44-5
Price: $318/5mg
(3,4-Dihydroxyphenyl)methyl 3-(bet...

Catalog No: CFN95531
CAS No: 877461-90-0
Price: $318/10mg
Isocarlinoside

Catalog No: CFN95092
CAS No: 83151-90-0
Price: $318/5mg
Momordicoside X

Catalog No: CFN95170
CAS No: 1333321-50-8
Price: $368/5mg
Maculosidin

Catalog No: CFN95126
CAS No: 522-19-0
Price: $413/5mg
Isocucurbitacin D

Catalog No: CFN95326
CAS No: 68422-20-8
Price: $318/5mg
4-O-Coumaroylquinic acid

Catalog No: CFN95508
CAS No: 53539-37-0
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7329 mL 8.6646 mL 17.3292 mL 34.6584 mL 43.3231 mL
5 mM 0.3466 mL 1.7329 mL 3.4658 mL 6.9317 mL 8.6646 mL
10 mM 0.1733 mL 0.8665 mL 1.7329 mL 3.4658 mL 4.3323 mL
50 mM 0.0347 mL 0.1733 mL 0.3466 mL 0.6932 mL 0.8665 mL
100 mM 0.0173 mL 0.0866 mL 0.1733 mL 0.3466 mL 0.4332 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry. 2013 Jan;85:185-93.
Characterization of chlorinated valepotriates from Valeriana jatamansi.[Pubmed: 23036722]

METHODS AND RESULTS:
HPLC-PDA-MS and TLC analysis were used to look for minor cytotoxic chlorinated valepotriates from whole plants of Valeriana jatamansi (syn. Valeriana wallichii DC.). This resulted in isolation of 15 chlorinated valepotriates, designated as chlorovaltrates A-O, together with six known analogues, (1S,3R,5R,7S,8S,9S)-3,8-epoxy-1,5-dihydroxyvalechlorine, Volvaltrate B, chlorovaltrate, rupesin B, (1S,3R,5R,7S,8S,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine, and (1R,3R,5R,7S,8S,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine. Their structures were elucidated by spectroscopic methods including homo- and heteronuclear two-dimensional NMR experiments.
CONCLUSIONS:
Chlorovaltrates K-N, chlorovaltrate and rupesin B showed moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC₅₀ values of 0.89-9.76 μM.
Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Isocorynoxeine

Catalog No: CFN98155
CAS No: 51014-29-0
Price: $128/20mg
Proline

Catalog No: CFN99612
CAS No: 147-85-3
Price: $30/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Morin

Catalog No: CFN99929
CAS No: 480-16-0
Price: $30/20mg
Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg
Notoginsenoside R4

Catalog No: CFN91142
CAS No: 87741-77-3
Price: $238/5mg
Praeruptorin B

Catalog No: CFN98140
CAS No: 81740-07-0
Price: $100/20mg
Alantolactone

Catalog No: CFN99934
CAS No: 546-43-0
Price: $30/20mg
Tags: buy Volvaltrate B | Volvaltrate B supplier | purchase Volvaltrate B | Volvaltrate B cost | Volvaltrate B manufacturer | order Volvaltrate B | Volvaltrate B distributor