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Wikstrol A
Wikstrol A
Information
CAS No. 159736-35-3 Price
Catalog No.CFN92960Purity>=98%
Molecular Weight542.49Type of CompoundFlavonoids
FormulaC30H22O10Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Wikstrol A

    Wikstrol A
    Product Name Wikstrol A
    CAS No.: 159736-35-3
    Catalog No.: CFN92960
    Molecular Formula: C30H22O10
    Molecular Weight: 542.49 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The roots of Daphne genkwa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Download: COA    MSDS
    Similar structural: Comparison (Web)  (SDF)
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    product package
  • Life Sci.2022, 298:120488.
  • Biomedicines.2020, 8(11):486.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Int J Mol Sci.2022, 23(24):16000.
  • Oncol Lett.2020, 20(4):122.
  • TCI CO.2019, US20190151281A1
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Food Chem.2020, 332:127412
  • Neuropharmacology.2018, 131:68-82
  • Separation Science Plus2022, sscp.202200048.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Wikstrol A is a natural product from Daphne genkwa.
    In vitro:
    Planta Med. 2000 Aug;66(6):564-7.
    Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.[Pubmed: 10985087]

    METHODS AND RESULTS:
    With guidance of Pyricularia oryzae bioassay, daphnoretin (1), (+)-nortrachelogenin (2), genkwanol A (3), Wikstrol A (4), wikstrol B (5) and daphnodorin B (6) were isolated from the roots of Wikstroemia indica. Compounds 1-6 induced morphological deformation of P. oryzae mycelia with MMDC values of 68.4 +/- 1.3, 31.3 +/- 1.8, 45.8 +/- 0.5, 70.1 +/- 2.4, 52.3 +/- 0.9 and 73.7 +/- 1.6 microM, respectively. Compounds 3-6 showed moderate activity against microtubule polymerization with IC50 values of 112 +/- 4, 131 +/- 3, 184 +/- 6 and 142 +/- 2 microM in vitro, respectively. Compounds 2, 3, 5 and 6 were moderately active against HIV-1 in vitro.
    CONCLUSIONS:
    The findings of bioactivity of 1-6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots.
    Pharmaceutical Biology, 2005, 43(1):12-14.
    Aldose Reductase Inhibitors from Stellera chamaejasme.[Reference: WebLink]

    METHODS AND RESULTS:
    Six biflavonoids (chamaejasmin, 7-methoxyneochamaejasmin, 7-methoxychamaejasmin, chamaejasmenin B, chamaechromone, Wikstrol A) from Stellera chamaejasme. L. have been assayed to show good aldose reductase inhibiting activity.
    CONCLUSIONS:
    These compounds may be useful to improve diabetic complications such as neuropathy, cataract formation, neophropathy, and retinopathy.
    Wikstrol A Description
    Source: The roots of Daphne genkwa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8434 mL 9.2168 mL 18.4335 mL 36.867 mL 46.0838 mL
    5 mM 0.3687 mL 1.8434 mL 3.6867 mL 7.3734 mL 9.2168 mL
    10 mM 0.1843 mL 0.9217 mL 1.8434 mL 3.6867 mL 4.6084 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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