ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $598.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J of the Korean Society of Cosmet...2018...J Phys Chem Lett.2021, 12(7):1793-1802.Molecules.2018, 23(2)Phytochem Anal.2013, 24(5):493-503RSC Advances2017, 86Proc Natl Acad Sci USA....2016...J Ethnopharmacol.2020, 260:112988.Journal of Apiculture...2019...
Cell Metab.2020, S1550-4131(20)30002-4Industrial Crops and Products...2017...Indian J. of Experimental Bio....2020...Arch Toxicol.2017, 91(10):3225-3245Front Pharmacol.2021, 12:770667.Int J Biol Macromol.2021, 199:189-200.Phytomedicine.2019, 57:95-104Front Pharmacol.2021, 12:652860.
Food Chem.2022, 373(Pt B):131364.Int J Mol Sci.2019, 21(1):E265Evid Based Complement Alternat Me...2022...Oncotarget.2017, 8(53):90925-90947Int Immunopharmacol.2021, 100:108073. Phytomedicine.2019, 58:152893Acta Physiologiae Plantarum2016, 38:7
Our products had been exported to the following research institutions and universities, And still growing.
Medical University of Gdansk (Poland)University of East Anglia (United Kingdom)Seoul National University of Sc... (Korea)Macau University of Science and... (China)
Utrecht University (Netherlands)Charles University in Prague (Czech Republic)University of Maryland School o... (USA)Kyung Hee University (Korea)
Technical University of Denmark (Denmark)Vin?a Institute of Nuclear Scie... (Serbia)University of Zurich (Switzerland)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2019, 24(6):E1155Plant Cell Physiol.2018, 59(1):128-141Front Pharmacol.2021, 12:615157.University of Central Lancashire2017, 20472Industrial Crops and Products2017, 95:286-295iScience.2020, 23(2):100849.PLoS One.2021, 16(9):e0257243.Int J Cosmet Sci.2019, 41(1):12-20J Sci Food Agric.2018, 98(3):1153-1161Front Plant Sci.2017, 8:723
Related Screening Libraries
|| Yadanzioside G has antileukemic activity. |
|Phytother Res. 2011 Dec;25(12):1796-800. |
|Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.[Pubmed: 21480411 ]|
|Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines.
METHODS AND RESULTS:
A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, yadanzioside A, Yadanzioside G, javanicoside C and bruceantinoside A. Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 μm and 0.10 μm on PANC-1 and SW1990 cell lines, respectively.
This is the first report on the antipancreatic adenocarcinoma activity of brusatol.
|Bull. Chem. Soc. Jpn.,1985, 58(9), 2680-6. |
|Structures of new quassinoid glycosides, yadanziosides A,B,C,D,E,G,H, and new quassinoids, dehydrobrusatol and dehydrobruceantinol from Brucea javanica (L.) Merr.[Reference: WebLink]|
METHODS AND RESULTS:
Quassinoid glycosides, yadanzioside A, yadanzioside B, yadanzioside C, yadanzioside D, yadanzioside E, Yadanzioside G, and yadanzioside H, and two quassinoids, dehydrobrusatol and dehydrobruceantinol were isolated from seeds of Brucea javanica, and their structures were determined.
These glycosides showed bitter taste and were demonstrated to have antileukemic activity.
Yadanzioside G Description
||The seeds of Brucea javanica.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Arch Pharm Res. 2011 Aug;34(8):1297-300. |
|One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051 ]|
|A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), Yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
METHODS AND RESULTS:
The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource