alpha-Conidendrin | CAS:85699-62-3 | Manufacturer ChemFaces

alpha-Conidendrin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Reference standards.

In vitro:

J Med Chem. 2001 Jan 18;44(2):180-5.

Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.[Pubmed: 11170627]

Derivatives of alpha-Conidendrin, podophyllotoxin, and sikkimotoxin were prepared to evaluate the cytotoxic contributions of C-4 configuration and pendant and fused arene substitutions.
METHODS AND RESULTS:
Dimethyl-alpha-conidendryl alcohol (5), 9-deoxypodophyllol (6), and 9-deoxysikkimol (17) were dehydrated to their respective oxolane derivatives 4, 3, and 9. Diols 5 and 6 were converted via oxabicyclo[3.2.1]octanols 10 and 14 to target oxolanes 8 and 7 where C-4 had been inverted relative to that in 3 and 4. Cytotoxicities of the five oxolanes were determined in two drug-sensitive human leukemia and two multidrug-resistant cell lines expressing P-glycoprotein or multidrug-resistance associated protein (MRP). Changing the pendant arene configuration or replacing a m-methoxy by hydrogen resulted in a 100-fold cytotoxicity loss. Replacing a methylenedioxy group in the fused arene by two methoxy substituents reduced cytotoxicity by 10-fold.
CONCLUSIONS:
Drug-resistant cell lines were equally resistant to compounds 3, 4, 8, and 9 indicating that these four compounds do not serve as substrates of the transport proteins P-glycoprotein and MRP.

alpha-Conidendrin Description

Source:	The barks of Tsuga dumosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	alpha-Conidendrin
Price:
CAS No.:	85699-62-3
Catalog No.:	CFN97420
Molecular Formula:	C₂₀H₂₀O₆
Molecular Weight:	356.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The barks of Tsuga dumosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8058 mL	14.0292 mL	28.0584 mL	56.1167 mL	70.1459 mL
5 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
10 mM	0.2806 mL	1.4029 mL	2.8058 mL	5.6117 mL	7.0146 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.5612 mL	0.7015 mL

CFN95702	Justicidin A	25001-57-4	394.4	C₂₂H₁₈O₇
CFN95703	Chinensinaphthol methyl ether	53965-11-0	394.4	C₂₂H₁₈O₇
CFN95704	Justicidin C(Neojusticin B)	17803-12-2	394.4	C₂₂H₁₈O₇
CFN95705	Justicidin D(Neojusticin A)	27041-98-1	378.3	C₂₁H₁₄O₇
CFN95174	Marginatoxin	1422536-56-8	398.4	C₂₂H₂₂O₇
CFN97279	gamma-Diasarone	80434-33-9	416.5	C₂₄H₃₂O₆
CFN97420	alpha-Conidendrin	85699-62-3	356.4	C₂₀H₂₀O₆
CFN92623	Isoanthricin	17301-70-5	398.4	C₂₂H₂₂O₇
CFN70412	alpha-Peltatin	568-53-6	400.4	C₂₁H₂₀O₈
CFN92699	(-)-beta-Peltatin	518-29-6	414.4	C₂₂H₂₂O₈