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    1-Methoxyberberine
    1-Methoxyberberine
    Information
    CAS No. 29133-52-6 Price
    Catalog No.CFN89079Purity>=98%
    Molecular Weight352.38Type of CompoundAlkaloids
    FormulaC21H20NO5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antifungal Compound Library
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  • Biological Activity
    Description: 1-Methoxyberberine chloride is a potential antifungal agent.
    Targets: Antifection
    In vitro:
    Folia Microbiol (Praha). 2003;48(5):605-9.
    Two plant alkaloids isolated from Corydalis longipes as potential antifungal agents.[Pubmed: 14976716]

    METHODS AND RESULTS:
    The alkaloids N-methylhydrasteine hydroxylactam and 1-Methoxyberberine chloride were isolated from Corydalis longipes. Both alkaloids showed high efficacy individually (in concentration of 50-150 ppm) and also in a 1:1 mixture against spore germination of some fungi, viz. Alternaria alternata, A. brassicae, Curvularia maculans, Curvularia sp., Colletotrichum gloeosporioides, Colletotrichum sp., Helminthosporium speciferum, H. pennisetti, Helminthosporium sp., and Ustilago cynodontis.
    CONCLUSIONS:
    The antifungal effect of single compounds was dose-dependent. If the mutual ratio of the two components in the mixture was changed from 1:1 to a major content of any of the two compounds, the inhibitory effect on spore germination decreased.
    1-Methoxyberberine Description
    Source: The herbs of Corydalis longipes.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

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    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8378 mL 14.1892 mL 28.3785 mL 56.7569 mL 70.9461 mL
    5 mM 0.5676 mL 2.8378 mL 5.6757 mL 11.3514 mL 14.1892 mL
    10 mM 0.2838 mL 1.4189 mL 2.8378 mL 5.6757 mL 7.0946 mL
    50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.1351 mL 1.4189 mL
    100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5676 mL 0.7095 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Nat Prod Res. 2009;23(3):250-5.
    New alkaloids from Corydalis species.[Pubmed: 19235025]

    METHODS AND RESULTS:
    A new alkaloid, chaerophylline (1), together with known alkaloids (-)-corypalmine, berberine chloride, (-)-isocorypalmine, (-)-corydalmine and (+)-bicuculline have been isolated from the crude base fraction of Corydalis chaerophylla. The crude base fractions of Corydalis longipes gave a new alkaloid, longicine (4), together with known alkaloids (+/-)-alpha-hydrastine, (+/-)-beta-hydrastine, N-methylhydrasteine hydroxylactam, 1-Methoxyberberine chloride and berberinium hydroxide.
    CONCLUSIONS:
    These alkaloids are reported for the first time from the above species and their structures were established by chemical and spectroscopic evidence.