• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    4',7-Dihydroxyflavone
    Information
    CAS No. 2196-14-7 Price $100 / 5mg
    Catalog No.CFN92855Purity>=98%
    Molecular Weight254.1Type of CompoundFlavonoids
    FormulaC15H10O4Physical DescriptionYellow cryst.
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Tohoku University (Japan)
  • University of Limpopo (South Africa)
  • University of Vienna (Austria)
  • Universitas islam negeri Jakarta (Indonesia)
  • The Ohio State University (USA)
  • Mahatma Gandhi University (India)
  • Sri Ramachandra University (India)
  • National Research Council of Can... (Canada)
  • St. Jude Children Research Hospi... (USA)
  • Heinrich-Heine-University Düsse... (Germany)
  • Guangzhou Institutes of Biomedic... (China)
  • More...
  • Package
    Featured Products
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $268/10mg
    Zederone

    Catalog No: CFN92616
    CAS No: 7727-79-9
    Price: $278/20mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $498/10mg
    Eleutheroside E

    Catalog No: CFN99984
    CAS No: 39432-56-9
    Price: $88/20mg
    4',7-Dihydroxyflavone Description
    Source: The heartwood of Pterocarpus marsupium
    Biological Activity or Inhibitors: 1. 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti.
    2. 4',7-Dihydroxyflavone has inhibitory activities against COX-2.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Kobusin

    Catalog No: CFN89280
    CAS No: 36150-23-9
    Price: $368/10mg
    Fargesin

    Catalog No: CFN98174
    CAS No: 31008-19-2
    Price: $128/20mg
    Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $498/10mg
    Yangambin

    Catalog No: CFN96416
    CAS No: 13060-14-5
    Price: $398/5mg
    Secologanic acid

    Catalog No: CFN95028
    CAS No: 60077-46-5
    Price: $318/10mg
    Calycosin-7-O-beta-D-glucoside

    Catalog No: CFN99141
    CAS No: 20633-67-4
    Price: $128/20mg
    11-Hydroxycanthin-6-one

    Catalog No: CFN92125
    CAS No: 75969-83-4
    Price: $413/5mg
    Naringin 4'-glucoside

    Catalog No: CFN95014
    CAS No: 17257-21-5
    Price: $338/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9355 mL 19.6773 mL 39.3546 mL 78.7092 mL 98.3865 mL
    5 mM 0.7871 mL 3.9355 mL 7.8709 mL 15.7418 mL 19.6773 mL
    10 mM 0.3935 mL 1.9677 mL 3.9355 mL 7.8709 mL 9.8386 mL
    50 mM 0.0787 mL 0.3935 mL 0.7871 mL 1.5742 mL 1.9677 mL
    100 mM 0.0394 mL 0.1968 mL 0.3935 mL 0.7871 mL 0.9839 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    4',7-Dihydroxyflavone References Information
    Citation [1]

    Molecules, 2008, 13(8):1530-7.

    Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.[Pubmed: 18794770]
    A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-Dihydroxyflavone (6)--and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.
    Citation [2]

    Plant Physiol., 1989, 91(3):842-7.

    A Chalcone and Two Related Flavonoids Released from Alfalfa Roots Induce nod Genes of Rhizobium meliloti.[Pubmed: 16667146 ]
    Flavonoid signals from alfalfa (Medicago sativa L.) induce transcription of nodulation (nod) genes in Rhizobium meliloti. Previous investigations identified the flavone luteolin as an active inducer in alfalfa seed extracts, but the nature of nod inducers released from roots has not been reported. Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates. The 4,4'-dihydroxy-2'-methoxychalcone induced nod genes at a concentration one order of magnitude lower than luteolin and is the first naturally released chalcone reported to have this function. Moderate and weak nod-inducing activity was associated, respectively, with 4',7-Dihydroxyflavone and 4',7-dihydroxyflavanone.