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    6,7-Dihydroneridienone A
    6,7-Dihydroneridienone A
    Information
    CAS No. 72959-46-7 Price
    Catalog No.CFN96120Purity>=98%
    Molecular Weight328.5Type of CompoundSteroids
    FormulaC21H28O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 6,7-Dihydroneridienone A exhibits notable leishmanicidal activity.
    Targets: Antifection
    In vitro:
    Planta Med 2012; 78 - PI239.
    Compounds with antileishmanial activity isolated from the stems of Pentalinon andrieuxii.[Reference: WebLink]

    METHODS AND RESULTS:
    Bioassay-guided fractionation was conducted on a chloroform-soluble extract of the stems of Pentalinon andrieuxii, a Mayan traditional antileishmanial plant collected in a rainforest region of Mexico, using a Leishmania (L.) mexicana strain of parasites. This led to the isolation of five C21 sterol derivatives, neridienone A (1), 6,7-Dihydroneridienone A (2), cybisterol (3), 12β-hydroxypregn-4-ene-3,20-dione (4), and pentalinonoside (5), two coumarins, fraxidin (6) and fraxetol (7), as well as betulinic acid (8) and (+)-pinoresinol (9).
    CONCLUSIONS:
    All the isolates were evaluated in vitro for their ability to inhibit the growth of promastigotes of L. mexicana. Compounds 1-4, and 6 were found to exhibit notable leishmanicidal activity in this assay.
    6,7-Dihydroneridienone A Description
    Source: The herbs of Tithonia diversifolia
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0441 mL 15.2207 mL 30.4414 mL 60.8828 mL 76.1035 mL
    5 mM 0.6088 mL 3.0441 mL 6.0883 mL 12.1766 mL 15.2207 mL
    10 mM 0.3044 mL 1.5221 mL 3.0441 mL 6.0883 mL 7.6104 mL
    50 mM 0.0609 mL 0.3044 mL 0.6088 mL 1.2177 mL 1.5221 mL
    100 mM 0.0304 mL 0.1522 mL 0.3044 mL 0.6088 mL 0.761 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.