|Targets:||BACE | Beta Amyloid|
|Source:||The herbs of Aloe arborescens Mill.|
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.7968 mL||8.9838 mL||17.9675 mL||35.935 mL||44.9188 mL|
|5 mM||0.3594 mL||1.7968 mL||3.5935 mL||7.187 mL||8.9838 mL|
|10 mM||0.1797 mL||0.8984 mL||1.7968 mL||3.5935 mL||4.4919 mL|
|50 mM||0.0359 mL||0.1797 mL||0.3594 mL||0.7187 mL||0.8984 mL|
|100 mM||0.018 mL||0.0898 mL||0.1797 mL||0.3594 mL||0.4492 mL|
Phytochemistry Volume 25, Issue 9, 1986, Pages 2219-2222
|A C-glucosylated 5-methylchromone from Kenya aloe[Reference: WebLink]|
|A new bitter C-glucoside, Aloeresin D, was isolated from a commercial sample of Kenya aloe. Its structure was assigned as 8-C-β-d-[2-O-(E)-p-coumaroyl]glucopyranosyl-2-[(R)-2-hydroxy]propyl-7-methoxy-5-methyl-chromone by spectral data and chemical transformations.|
Planta Med. 2008 Apr;74(5):540-5.
|BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis.[Pubmed: 18543151]|
|Four new chromone glycosides allo-Aloeresin D (2) , C-2'-decoumaroyl-aloeresin G (8), 2'-O-coumaroyl-(S)-aloesinol (9), 2'-O-[ P-methoxy-(E)-cinnamoyl]-(S)-aloesinol (10) and nine known chromone glycosides ( 1, 3 - 7, 11 - 13) were isolated from two Aloe spp. plants, A. vera and A. nobilis. Among them, 1 and 8 showed significant inhibitory activity against BACE1 (beta-secretase) with IC (50) values of 39.0 and 20.5 x 10 (-6) M, as well as inhibition of Abeta (1-42) production by 7.4 and 12.3 %, respectively, in B103 neuroblastoma cells at 30 ppm. The preliminary structure-activity relationships of ALOE chromone glucosides were also discussed.|