|Source:||The herbs of Artemisia annua|
|Biological Activity or Inhibitors:||1. Arteannuin B has potent antimalarial activity.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||4.0274 mL||20.1369 mL||40.2739 mL||80.5477 mL||100.6847 mL|
|5 mM||0.8055 mL||4.0274 mL||8.0548 mL||16.1095 mL||20.1369 mL|
|10 mM||0.4027 mL||2.0137 mL||4.0274 mL||8.0548 mL||10.0685 mL|
|50 mM||0.0805 mL||0.4027 mL||0.8055 mL||1.611 mL||2.0137 mL|
|100 mM||0.0403 mL||0.2014 mL||0.4027 mL||0.8055 mL||1.0068 mL|
J Sep Sci. 2005 Nov;28(17):2288-92.
|Simultaneous densitometric determination of artemisinin, artemisinic acid and arteannuin-B in Artemisia annua using reversed-phase thin layer chromatography.[Pubmed: 16342793]|
|A rapid and simple RP-TLC method for simultaneous quantification of pharmacologically important sesquiterpene artemisinin (AM) together with its precursors Arteannuin B (AB) and artemisinic acid (AA) in the inflorescence part of Artemisia annua plant has been developed. The RP-TLC of sesquiterpenes was performed on RP-18 F254 S thin-layer chromatographic plates by developing in mobile phase, containing 0.2% TFA in water/ACN (35:65, v/v). The densitometric determination of AM, Arteannuin B and AA was carried out after derivatization with anisaldehyde reagent at 426 nm in absorption-reflectance mode.|
J Nat Prod. 1993 Sep;56(9):1559-66.
|Bioconversion of arteannuin B to artemisinin.[Pubmed: 8254350]|
|Arteannuin B, which co-occurs with artemisinin, the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae), has been converted to the latter using crude and semi-purified cell-free extracts of the leaf homogenates of the plant. Detection procedures to quantitate this bioconversion, including one that is novel which uses gcms, are detailed.|
Yao Xue Xue Bao. 1992;27(4):317-20.
|Derivatives of arteannuin B with antileukemia activity[Pubmed: 1442049]|
|Arteannuin B (I) was converted to hydroxy lactones (VII, VIII) by a mixture of formic acid and sulfuric acid. Compound VI and Compound VII both showed activity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5% and 11.8% for (VI) and 80% and 52.6% for (VII) at the concentration of 10 and 1 micrograms/ml respectively. It seems that the antileukemia activity of 6-membered lactone is higher than that of 5-membered and the methylene group is necessary for the antileukemia activity.|