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    Benzylamine
    Benzylamine
    Information
    CAS No. 100-46-9 Price
    Catalog No.CFN00064Purity>=98%
    Molecular Weight107.15Type of CompoundAlkaloids
    FormulaC7H9NPhysical DescriptionOil
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Benzylamine Description
    Source: The herbs of Moringa oleifera
    Biological Activity or Inhibitors: 1. Benzylamine has antihyperglycemic effect, observed during glucose tolerance test in control.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 9.3327 mL 46.6636 mL 93.3271 mL 186.6542 mL 233.3178 mL
    5 mM 1.8665 mL 9.3327 mL 18.6654 mL 37.3308 mL 46.6636 mL
    10 mM 0.9333 mL 4.6664 mL 9.3327 mL 18.6654 mL 23.3318 mL
    50 mM 0.1867 mL 0.9333 mL 1.8665 mL 3.7331 mL 4.6664 mL
    100 mM 0.0933 mL 0.4666 mL 0.9333 mL 1.8665 mL 2.3332 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Benzylamine References Information
    Citation [1]

    Bioorg Med Chem. 2014 Mar 1;22(5):1558-67.

    Synthesis of 2,6-disubstituted benzylamine derivatives as reversible selective inhibitors of copper amine oxidases.[Pubmed: 24529308]
    We synthesized a set of Benzylamine derivatives properly substituted at positions 2 and 6 and studied their biological activity towards some members of CAOs. With Benzylamines 6, 7, 8 containing linear alkoxy groups we obtained reversible inhibitors of Benzylamine oxidase (BAO), very active and selective toward diamine oxidase (DAO), lysyl oxidase (LO) and monoamine oxidase B (MAO B) characterized by a certain toxicity consequent to the crossing of the brain barrier. Poorly toxic, up to very active, reversible inhibitors of BAO, very selective toward DAO, LO and MAO B, were obtained with Benzylamines 10, 11, 12 containing hydrophilic ω-hydroxyalkoxy groups. With Benzylamines 13, 14, 15, containing linear alkyl groups endowed with steric, but not conjugative effects for the absence of properly positioned oxygen atoms, we synthesized moderately active inhibitors of BAO reversible and selective toward DAO, LO and MAO B.
    Citation [2]

    Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 5;125:297-307.

    Spectroscopic, crystallographic and theoretical studies of lasalocid complex with ammonia and benzylamine.[Pubmed: 24562161]
    A natural antibiotic--Lasalocid is able to form stable complexes with ammonia and organic amines. New complexes of lasalocid with Benzylamine and ammonia were obtained in the crystal forms and studied using X-ray, FT-IR, (1)H NMR, (13)C NMR and DFT methods. These studies have shown that in both complexes the proton is transferred from the carboxylic group to the amine group with the formation of a pseudo-cyclic structure of lasalocid anion complexing the protonated amine or NH4(+) cation. The spectroscopic and DFT studies demonstrated that the structure of the complex formed between Lasalocid and Benzylamine in the solid is also conserved in the solution and gas phase. In contrast, the structure of the complex formed between lasalocid and ammonium cation found in the solid state undergoes dissociation in chloroform solution accompanied with a change in the coordination form of the NH4(+) cation.
    Citation [3]

    Bioorg Med Chem Lett. 2013 Apr 1;23(7):2177-80.

    Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.[Pubmed: 23453841]
    Potent small molecule antagonists of the urotensin receptor are described. These inhibitors were derived via systematically deconstructing a literature inhibitor to understand the basic pharmacophore and key molecular features required to inhibit the protein receptor. The series of Benzylamine and benzylsulfone antagonists herein reported display a combination of nanomolar molecular and cellular potency as well as acceptable in vitro permeability and metabolic stability.
    Citation [4]

    J Enzyme Inhib Med Chem. 2014 Apr;29(2):168-74.

    Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives.[Pubmed: 23391138]
    Synthesis and carbonic anhydrase inhibitory properties of novel diarylmethylamines 22-25 and sulfonamide derivatives 26-28 were investigated. Acylation of methoxy-substituted benzenes with benzene carboxylic acids, reduction of ketones with NaBH4, conversion of alcohols to azides, Pd-C catalyzed hydrogenation of azides afforded title compounds 22-25. Compounds 22, 24 and 25 were converted to sulfonamide derivatives 26-28 with MeSO2Cl. The inhibitory effects of novel Benzylamine derivatives 22-28 were tested on human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes hCA I and II. The results demonstrated that compound 28 was found to be the best inhibitor against both hCA I (Ki: 3.68 µM) and hCA II (Ki: 9.23 µM).
    Citation [5]

    J Physiol Biochem. 2012 Dec;68(4):651-62.

    Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter.[Pubmed: 22547093]
    We investigated whether it was necessary and/or sufficient to produce the antihyperglycemic effect of the SSAO-substrate Benzylamine, already reported in mice.As a consequence, the Benzylamine antihyperglycemic effect observed during glucose tolerance test in control was abolished in AOC3-KO mice but not rescued in mice expressing aP2-hAOC3. The capacity of Benzylamine or methylamine to activate glucose uptake in adipocytes exhibited parallel variations in the corresponding genotypes. Although the aP2-hAOC3 construct did not allow a total rescue of SSAO activity in adipose tissue, it could be assessed from our observations that adipocyte SSAO plays a pivotal role in the increased glucose tolerance promoted by pharmacological doses of Benzylamine.