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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $121.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Scientific World Journal....2014...Food Research International...2016...J Ethnopharmacol.2016, 192:370-381Chemistry of Plant Materials....2016...Oncol Rep.2016, 35(3):1356-64Food and Bioprocess Technology...2017...Nat Prod Commun.2017, 12(5):771-778Srinagarind Medical Journal2017, 32(1)
The Japan Society for Analytical ...2017...Viruses.2017, 9(10)Molecules.2018, 23(12):E3103Asian Journal of Chemistry...2018...Sci Rep.2018, 8:15059J Sci Food Agric.2018, 98(3):1153-1161BMC Complement Altern Med....2019...Int J Mol Sci.2019, 20(21):E5488
Molecules.2019, 24(21):E3834Med Sci Monit.2019, 25:9499-9508Chemistry of Plant Raw Materials...2019...Toxicol In Vitro.2019, 59:161-178Comput Biol Chem.2019, 83:107096Process Biochemistry2019, 87:213-220Industrial Crops and Products...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Heidelberg University (Germany)Imperial College London (United Kingdom)Copenhagen University (Denmark)Donald Danforth Plant Science C... (USA)
Tokyo Woman's Christian University (Japan)Deutsches Krebsforschungszentrum (Germany)Heinrich-Heine-University Düss... (Germany)Fraunhofer-Institut für Moleku... (Germany)
Institute of Tropical Disease U... (Indonesia)University of Wuerzburg (Germany)Nanjing University of Chinese M... (China)
Related Screening Libraries
||Corynoxine is a natural autophagy enhancer, promotes the clearance of Alpha-synuclein via Akt/mTOR pathway, it can significantly inhibit the oxidative stress of PC12 cells.|
||Akt | mTOR | Autophagy|
|Internal Medicine of China,2013,8(6):586-7. |
|Study on application of statistical modeling on chromatogram-effect relation in Traditional Chinese Medicine[Reference: WebLink]|
|To establish chromatogram-effect model based on inhibitory effect of four alkaloids( rhynchophyline,isorhynchophylline,Corynoxine,Corynoxine B) on oxidative stress of glutamate-induced PC12 cells. |
METHODS AND RESULTS:
Based on the chromatogram-effect relation of inhibitory effect of four alkaloids on the oxidative stress of glutamate-induced PC12 cells,SPSS 15. 0 was used to analyse data. Oxidative stress of PC12 cells was significantly inhibited by rhynchophyline and Corynoxine. The spectrum efficient equation was,Y = 44. 301 + 0. 255X 1 + 0. 356X 3( P 0. 05). The deviation of predictive value and true value was no more than 10% by data validation from seven samples.
The chromatogram-effect model can be used to predict the effect of uncaria macrophylla wall against the oxidative stress of glutamate-induced PC12 cells.
|Phytomedicine. 1999 Jul;6(3):163-8. |
|Effect on locomotion of indole alkaloids from the hooks of uncaria plants.[Pubmed: 10439480]|
METHODS AND RESULTS:
Three predominant Uncariae plants, Uncaria rhynchophylla U. sinensis and U. macrophylla and their indole and oxindole alkaloid constituents were studied for their effect on locomotor response. Water extracts of U. macrophylla and U. sinensis and four indole alkaloids, Corynoxine, Corynoxine B, isorhynchophylline and geissoschizine methyl ether, significantly decreased locomotor activity after oral administration to mice.
The depression of locomotor activity upon administration of these alkaloids appears to be due to mediating of the central dopaminergic system.
||The vines of Uncaria rhynchopylla.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7. |
|Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway.[Pubmed: 24522518]|
|Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein (α-syn) is the major component of Lewy bodies in PD patients, and impairment of the autophagy-lysosomal system has been linked to its accumulation. In our previous study, we identified an oxindole alkaloid Corynoxine B (Cory B), isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese), as a Beclin-1-dependent autophagy inducer. |
METHODS AND RESULTS:
In this work, we show that Cory, an enantiomer of Cory B, also induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells, which is paralleled with increased lysosomal enzyme cathepsin D. In vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase.
Collectively, our findings provide experimental evidence for developing Cory as a new autophagy enhancer from Chinese herbal medicine, which may have potential application in the prevention or treatment of PD.