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    Cyclo(Pro-Val)
    Cyclo(Pro-Val)
    Information
    CAS No. 5654-87-5 Price $332 / 10mg
    Catalog No.CFN90275Purity>=98%
    Molecular Weight196.25Type of CompoundMiscellaneous
    FormulaC10H16N2O2Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $169.4 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Cyclo(Pro-Val) shows cyctoxic, moderate antifungal and weak antitumor activities in vitro, it can inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8 g/L. Cyclo(Pro-Val) and cyclo(Pro-Tyr) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode.
    Targets: Antifection
    In vitro:
    Journal of Shenyang Pharmaceutical University, 2007,24(8) :474-8.
    Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007).[Reference: WebLink]
    To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.
    METHODS AND RESULTS:
    Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis.MTT assay was used to evaluate the bioactivities in vitro. Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),cyclo-(Phe-Val)(3),cyclo-(Ile-Leu)(3),cyclo-(Val-Val)(4),Cyclo(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
    CONCLUSIONS:
    All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,3 and 5 show cytotoxic activity in vitro.
    Tetrahedron Lett.,2002, 33(51):6545-8.
    Antifungal cyclopeptides from Halobacillus litoralis YS3106 of marine origin.[Reference: WebLink]

    METHODS AND RESULTS:
    Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B and C (two cyclic tetrapeptides), together with three known cyclic dipeptides, Cyclo(Pro-Val), cyclo(Pro-Leu) and cyclo(Ile-Val) were isolated from the ferment broth of a marine sediment-derived Halobacillus litoralis YS3106.
    CONCLUSIONS:
    The cyclopeptides show surprisingly simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro.
    Cyclo(Pro-Val) Description
    Source: From Penicillium oxalicum.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0955 mL 25.4777 mL 50.9554 mL 101.9108 mL 127.3885 mL
    5 mM 1.0191 mL 5.0955 mL 10.1911 mL 20.3822 mL 25.4777 mL
    10 mM 0.5096 mL 2.5478 mL 5.0955 mL 10.1911 mL 12.7389 mL
    50 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.0382 mL 2.5478 mL
    100 mM 0.051 mL 0.2548 mL 0.5096 mL 1.0191 mL 1.2739 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nematol. 2007 Sep;39(3):243-7.
    Two Cyclic Dipeptides from Pseudomonas fluorescens GcM5-1A Carried by the Pine Wood Nematode and Their Toxicities to Japanese Black Pine Suspension Cells and Seedlings in vitro.[Pubmed: 19259494]
    Pseudomonas fluorescens GcM5-1A, isolated from the pine wood nematode (PWN), Bursaphelenchus xylophilus, was cultured in Luria Broth medium (LB).
    METHODS AND RESULTS:
    The clarified culture was extracted with ethyl acetate, and two dipeptides were purified from the extract. The chemical structures of 1 and 2 were identified as Cyclo(Pro-Val)and cyclo(-Pro-Tyr-), respectively, by MS, (1)H NMR, (13)C NMR,(1)H-(1)H COSY, 1H -(13)C COSY spectra.
    CONCLUSIONS:
    Bioassay results showed that the two compounds were toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by PWN.