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    Dihydrocholesterol
    Dihydrocholesterol
    Information
    CAS No. 80-97-7 Price $70 / 20mg
    Catalog No.CFN90608Purity>=98%
    Molecular Weight388.67Type of CompoundSteroids
    FormulaC27H48OPhysical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Dihydrocholesterol is equally effective in reducing plasma cholesterol as β-sitosterol at a low dose, which is mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.
    In vivo:
    Br J Exp Pathol. 1979 Jun;60(3):231-8.
    Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury.[Pubmed: 383127]
    Rabbits fed a diet containing 0.75% Dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder.
    METHODS AND RESULTS:
    In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological changes was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells.
    CONCLUSIONS:
    It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholelithiasis.
    Atherosclerosis. 2015 Sep;242(1):77-86.
    Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters.[Pubmed: 26184696 ]
    Cholesterol analogs have been used to treat hypercholesterolemia. The present study was to examine the effect of Dihydrocholesterol (DC) on plasma total cholesterol (TC) compared with that of β-sitosterol (SI) in hamsters fed a high cholesterol diet.
    METHODS AND RESULTS:
    Forty-five male hamsters were randomly divided into 6 groups, fed either a non-cholesterol diet (NCD) or one of five high-cholesterol diets without addition of DC and SI (HCD) or with addition of 0.2% DC (DA), 0.3% DC (DB), 0.2% SI (SA), and 0.3% SI (SB), respectively, for 6 weeks. Results showed that DC added into diet at a dose of 0.2% could reduce plasma TC by 21%, comparable to that of SI (19%). At a higher dose of 0.3%, DC reduced plasma TC by 15%, less effective than SI (32%). Both DC and SI could increase the excretion of fecal sterols, however, DC was more effective in increasing the excretion of neutral sterols but it was less effective in increasing the excretion of acidic sterols compared with SI. Results on the incorporation of sterols in micellar solutions clearly demonstrated both DC and SI could displace the cholesterol from micelles with the former being more effective than the latter.
    CONCLUSIONS:
    DC was equally effective in reducing plasma cholesterol as SI at a low dose. Plasma TC-lowering activity of DC was mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.
    Dihydrocholesterol Description
    Source: The testes of White Carneau pigeons.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5729 mL 12.8644 mL 25.7288 mL 51.4575 mL 64.3219 mL
    5 mM 0.5146 mL 2.5729 mL 5.1458 mL 10.2915 mL 12.8644 mL
    10 mM 0.2573 mL 1.2864 mL 2.5729 mL 5.1458 mL 6.4322 mL
    50 mM 0.0515 mL 0.2573 mL 0.5146 mL 1.0292 mL 1.2864 mL
    100 mM 0.0257 mL 0.1286 mL 0.2573 mL 0.5146 mL 0.6432 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.