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    Esculentoside H
    Information
    CAS No. 66656-92-6 Price $248 / 20mg
    Catalog No.CFN90657Purity>=98%
    Molecular Weight989.1Type of CompoundTriterpenoids
    FormulaC48H76O21Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $161.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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  • Biological Activity
    Description: Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
    Targets: TNF-α
    In vitro:
    Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.
    Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages.[Pubmed: 8010057]

    METHODS AND RESULTS:
    Effect of Esculentoside H (EH) on release of tumor necrosis factor (TNF) from murine peritoneal macrophage (Mphi) in vitro was studied. The results showed that Esculentoside H (12.5-200 micrograms.ml-1) induced the thioglycolate-broth elicited peritoneal Mphi to release TNF into supernatants in a dose-dependent manner, and higher levels of TNF activity were detected in the supernatants from Esculentoside H-stimulated calcimycin-primed Mø culture. Esculentoside H-induced TNF release had a different type of kinetics compared with that of lipopolysaccharides (LPS). LPS-induced release of TNF increased rapidly until 6 h after LPS stimulation, then declined gradually, while Esculentoside H-induced TNF release increased gradually after Esculentoside H stimulation and reached its peak at approximately 24 h later.
    CONCLUSIONS:
    These results suggested that the anti-tumor mechanisms of Phytolaccaceae may be related to the capacity of Esculentoside H for TNF release.
    Esculentoside H Description
    Source: The roots of Phytolacca acinosa Roxb.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.011 mL 5.0551 mL 10.1102 mL 20.2204 mL 25.2755 mL
    5 mM 0.2022 mL 1.011 mL 2.022 mL 4.0441 mL 5.0551 mL
    10 mM 0.1011 mL 0.5055 mL 1.011 mL 2.022 mL 2.5276 mL
    50 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.4044 mL 0.5055 mL
    100 mM 0.0101 mL 0.0506 mL 0.1011 mL 0.2022 mL 0.2528 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.