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    Natural Products
    Gelsevirine
    Gelsevirine
    Information
    CAS No. 38990-03-3 Price
    Catalog No.CFN98622Purity>=98%
    Molecular Weight352.4 Type of CompoundAlkaloids
    FormulaC21H24N2O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
  • Anxiolytic Compound Library
  • Alkaloids Compound Library
  • Biological Activity
    Description: Gelsevirine has anxiolytic activity, may be via the agonist action of glycine receptor in the brain. Gelsevirine can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively.
    In vitro:
    Strait Pharmaceutical Journal, 2010 , 22 (3) :197-200.
    Cytotoxic effects of alkaloidal compounds from Gelsemium elegans Benth on the tumor cells of digestive system in vitro[Reference: WebLink]
    To investigate the antitumor activity of alkaloid compounds from Gelsemium elegans Benth by cytotoxicity assay on digestive system tumor cells(SW480,MGC80-3,TE-11,HepG2)and analyse their structure-activity relationship.
    METHODS AND RESULTS:
    Four alkaloid compounds were assessed for cytotoxic activity using the microculture 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay for cellular viability. The results showed that Koumine,Gelsemine,Gelsenicine and Gelsevirine could significantly inhibite the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner.The 50% inhibiting concentration(IC50)of Koumine,Gelsemine,Gelsenicine and Gelsevirine on SW480 cells were 0.45±0.10,0.76±0.28,0.52±0.22 and 1.41±0.06 mmol·L-1 respectively,and were 0.82±0.19,1.20±0.33,1.14±0.23 and1.22±0.11 mmol·L-1 respectively on MGC80-3 cells.Koumine,Gelsemine and Gelsenicine also could inhibite the proliferation of TE-11 and HepG2 cells in a dose-dependent manner.IC50 of Koumine,Gelsemine and Gelsenicine on TE-11 cells were 0.74±0.05,1.94±0.30 and 1.73±0.35 mmol·L-1 respectively,and were 1.26±0.32,1.82±0.35 and 1.79±0.54 mmol·L-1 respectively on HepG2 cells.
    CONCLUSIONS:
    The alkaloid compounds from Gelsemium elegans Benth had obvious antitumor activity on digestive system tumor cells in vitro.Moreover there is a close relationship between their structure and effect.
    In vivo:
    Psychopharmacology (Berl). 2013 Feb;225(4):839-51.
    The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics.[Pubmed: 23052566]
    An increasing number of herbal products has been introduced to treat anxiety and depression. Gelsemium elegans Benth (G. elegans) is a well-known herbal plant in Asia. Four major alkaloids (gelsemine, koumine, Gelsevirine, and gelsenicine) have been isolated from G. elegans.
    METHODS AND RESULTS:
    Gelsemine, koumine, and Gelsevirine, but not gelsenicine, exhibited potent anxiolytic effects in the two anxiety models. None of the four G. elegans alkaloids exerted antidepressant effects in the two depression models. None of G. elegans alkaloids impaired spontaneous motor activities. The intracerebroventricular administration of strychnine significantly antagonized the anxiolytic effects of gelsemine, koumine, and Gelsevirine administrated subcutaneously.
    CONCLUSIONS:
    Gelsemine, koumine, and Gelsevirine could be developed as the treatment of anxiety-related disorders in human patients. Their anxiolytic mechanism may be involved in the agonist action of glycine receptor in the brain.
    Gelsevirine Description
    Source: The herbs of Gelsemium elegans
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8377 mL 14.1884 mL 28.3768 mL 56.7537 mL 70.9421 mL
    5 mM 0.5675 mL 2.8377 mL 5.6754 mL 11.3507 mL 14.1884 mL
    10 mM 0.2838 mL 1.4188 mL 2.8377 mL 5.6754 mL 7.0942 mL
    50 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.1351 mL 1.4188 mL
    100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5675 mL 0.7094 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.