ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Nat Plants. 2016 Dec 22Biol Pharm Bull.2017;40(6)Polytechnic University of Catalonia2016Tumour Biol.2015 Apr 12.Molecules. 2017 Jun 2;
Int J Mol Sci. 2017 May 11;J Ethnopharmacol. 2016 Jul 12.Int J Mol Sci. 2017 Dec 21;Molecules 2016, 21(6), 739;2016 Jun 14;21(6). JPCJuly 12, 2017
Research on Crops.Jun 2017;Biochem Systematics and EcologyOctober 2017;Oncology LettersJan. 25, 2018;J Sep Sci.2018 Jan 23.
Our products had been exported to the following research institutions and universities, And still growing.
Georgia Institute of Technology (USA)Cancer Research Initatives Found... (Malaysia)Universidade de Franca (Brazil)University of Cincinnati (USA)
University of Amsterdam (Netherlands)University of Malaya (Malaysia)Worcester Polytechnic Institute (USA)Utah State University (USA)
Mendel University in Brno (Czech Republic)National Cancer Institute (USA)University of Sao Paulo (Brazil)
||Isoacetovanillone shows anti-inflammatory potential.|
||Immunology & Inflammation related|
|Res Pharm Sci. 2015 Jul-Aug;10(4):345-55. |
|Anti-inflammatory effect of Pycnocycla spinosa extract and its component isoacetovanillone on acetic acid induced colitis in rats.[Pubmed: 26600861 ]|
|Colitis is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Pycnocycla spinosa Boiss. on the treatment of experimental colitis. Mediators involved in colonic inflammation are prostaglandins, interleukins, leukotriene as well as an increase in myeloperoxidase (MPO) activity.
METHODS AND RESULTS:
Therefore, MPO activity was also determined in this research. P. spinosa hydroalcoholic extract (5, 10 and 20 mg/kg) or Isoacetovanillone (2, 5 and 10 mg/kg) were administered orally, started 2 h before induction of colitis by intrarectal administration of acetic acid (3%) in rats. Prednisolone (4 m/kg) was used as the standard drug for comparison. Biochemical evaluation of inflamed colon was done using assay of MPO activity. After 5 days treatments, mucosal ulceration was evaluated. Intrarectal instillation of acetic acid caused significant inflammatory reactions as indicated by macroscopic and microscopic changes. The activity of MPO increased in vehicle treated groups while recovered to normal level by pretreatment of animals with P. spinosa extract, Isoacetovanillone and prednisolone. P. spinosa and Isoacetovanillone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the vehicle treated negative control group. The beneficial effect of P. spinosa was comparable with that of prednisolone.
This research has shown the anti-inflammatory potential of P. spinosa extract and Isoacetovanillone in experimentally induced colitis.
||The herbs of Pycnocycla spinosa Boiss.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.