ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $144.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Breast Cancer.2015, 18(2):112-118BMC Complement Altern Med.2016, 16:213Nat Prod Sci.2016, 22(2)Acta Chromatographica2016, 29(3)Semyung University2017, 149407J Ethnopharmacol.2017, 196:75-83J of L. Chroma.&Related Tech...2017...Srinagarind Medical Journal2017, 32(1)
Sci Rep.2017, 7(1):3249Oncotarget.2017, 9(3):4161-4172Industrial Crops and Products...2017...Int J Biol Macromol.2018, 112:1093-1103J Pharm Biomed Anal.2018, 151:32-41Biochemistry.2018, 57(40):5886-5896Pathogens.2018, 7(3):E62Nat Commun.2019, 10(1):5169
J Cancer.2019, 10(23):5843-5851Int J Mol Sci.2019, 20(14):E3538Med Sci Monit.2019, 25:9499-9508Korean J of Crop Science2019, 452-458Process Biochemistry2019, 85:106-115Process Biochemistry2019, 87:213-220J Mol Recognit.2020, 33(2):e2819
Our products had been exported to the following research institutions and universities, And still growing.
Nicolaus Copernicus Uniwersity (Poland)Charles Sturt University (Denmark)Max-Planck-Insitut (Germany)Almansora University (Egypt)
University of Canterbury (New Zealand)University of Virginia (USA)University of Maryland School o... (USA)Seoul National University (Korea)
University of Madras (India)Fraunhofer-Institut für Moleku... (Germany)Kyoto University (Japan)
Related Screening Libraries
|| Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.|
||NF-kB | ERK|
|Int Immunopharmacol. 2016 Sep;38:175-85. |
|Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway.[Pubmed: 27285671 ]|
|Macrophage polarization plays an important role in inflammation. Regulation of the polarization has been reported to be effective therapeutics for various kinds of inflammatory diseases. The aims of the present study were to investigate the anti-inflammatory property of Isomeranzin isolating from Murraya exotica as well as potential molecular mechanisms.
METHODS AND RESULTS:
Results showed that Isomeranzin specifically reduced the M1 macrophage-associated pro-inflammatory cytokines through down-regulation of NF-κB and ERK signals. Immunoprecipitation and RNA silencing indicated suppression of Isomeranzin in NF-κB activation was relying on the decreasing of TRAF6 ubiquitination. In vivo studies showed Isomeranzin evidently inhibited LPS-induced sepsis for rising survival rate, improving tissue damage and lessening inflammatory cytokines. In accordance with in vitro studies, Isomeranzin significantly blocked expression of p-p65 and p-ERK in lung and liver tissues. Moreover, Isomeranzin ameliorated DSS and TNBS-induced colitis due to its anti-inflammatory effects.
Taken together, Isomeranzin suppressed inflammatory diseases by controlling M1 macrophage polarization through the NF-κB and ERK pathway.
||The peels of Citrus maxima
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.