Kansuinine B | CAS:57685-46-8 | Manufacturer ChemFaces

Kansuinine B

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Size /Price /Stock	10 mM * 1 mL in DMSO / $490.1 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Kansuinine B Description

Source:	The roots of Euphorbia kansui
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2010 Oct;76(14):1544-9.

Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation.[Pubmed: 20379953]

The current study was performed to examine the mechanisms underlying the potential effects of E. KANSUI on IL-6-induced cellular signaling in human hepatoma cells.
METHODS AND RESULTS:
We found that two diterpenoids, kansuinine A and Kansuinine B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and Kansuinine B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and Kansuinine B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression.
CONCLUSIONS:
Treatment with kansuinine A and Kansuinine B represents a novel method to block these IL-6-induced effects.

Product Name	Kansuinine B
Price:	$338 / 5mg
CAS No.:	57685-46-8
Catalog No.:	CFN92866
Molecular Formula:	C₃₈H₄₂O₁₄
Molecular Weight:	722.7 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The roots of Euphorbia kansui
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Toxicity Compound Library Diterpenoids Compound Library STAT Inhibitor Library MEK Inhibitor Library IL Receptor Inhibitor Library ERK Inhibitor Library

Description:	Kansuinine B shows cytotoxic ,and analgesic activities, treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects.
Targets:	IL Receptor \| STAT \| ERK \| MEK

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3837 mL	6.9185 mL	13.837 mL	27.674 mL	34.5925 mL
5 mM	0.2767 mL	1.3837 mL	2.7674 mL	5.5348 mL	6.9185 mL
10 mM	0.1384 mL	0.6919 mL	1.3837 mL	2.7674 mL	3.4593 mL
50 mM	0.0277 mL	0.1384 mL	0.2767 mL	0.5535 mL	0.6919 mL
100 mM	0.0138 mL	0.0692 mL	0.1384 mL	0.2767 mL	0.3459 mL

CFN92869	Kansuinine E	672945-84-5	777.8	C₄₁H₄₇NO₁₄
CFN89380	Jatrophane I	210108-85-3	699.74	C₃₆H₄₅NO₁₃
CFN89381	Jatrophane VI	210108-90-0	716.76	C₃₇H₄₈O₁₄
CFN98054	Jatrophane 4	210108-88-6	744.8	C₃₉H₅₂O₁₄
CFN98052	Jatrophane 2	210108-86-4	758.8	C₃₉H₅₀O₁₅
CFN98055	Jatrophane 5	210108-89-7	779.8	C₄₁H₄₉NO₁₄
CFN98053	Jatrophane 3	210108-87-5	807.9	C₄₃H₅₃NO₁₄
CFN97144	Pepluanin A	670257-89-3	821.9	C₄₃H₅₁NO₁₅
CFN92863	Kansuinine A	57701-86-7	730.8	C₃₇H₄₆O₁₅
CFN92866	Kansuinine B	57685-46-8	722.7	C₃₈H₄₂O₁₄