Kimcuongin | CAS:1872403-23-0 | Manufacturer ChemFaces

Kimcuongin

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Description:

Kimcuongin shows vasorelaxing activity with IC50 values of 37.7 uM.

In vitro:

Biol Pharm Bull. 2014;37(4):694-7.

Vasorelaxing activity of two coumarins from Murraya paniculata leaves.[Pubmed: 24694618]

In the search for novel chemical scaffolds leading to potential antihypertensive agents, the methanol extract of Murraya paniculata leaves was assessed for its effects on isolated rat aorta rings.
METHODS AND RESULTS:
The vasorelaxing effect of the chloroform fraction of the methanol plant extract was the most potent for its vasorelaxing activity on rat aorta rings contracted by 60 mM K(+) (K60). Two coumarins were isolated from the chloroform fraction: the novel Kimcuongin (1) and the known murracarpin (2). Their structures were determined from spectroscopic evidences including (1)H- and (13)C-NMR, correlation spectroscopy (COSY), nuclear Overhauser effect spectroscopy (NOESY), heteronuclear multiple bond correlation (HMBC), heteronuclear single quantum correlation (HSQC), and high resolution mass spectrometry (HR-MS). Kimcuongin and, to a lesser extent, murracarpin, showed vasorelaxing activity with IC50 values of 37.7 μM and 139.3 μM, respectively.
CONCLUSIONS:
The coumarins Kimcuongin and murracarpin may thus represent a novel class of vasodilators of natural source.

Kimcuongin Description

Source:	The leaves of Murraya paniculata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Kimcuongin
Price:
CAS No.:	1872403-23-0
Catalog No.:	CFN89184
Molecular Formula:	C₂₀H₂₀O₆
Molecular Weight:	356.37 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The leaves of Murraya paniculata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Vasorelaxation Compound Library Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8061 mL	14.0304 mL	28.0607 mL	56.1214 mL	70.1518 mL
5 mM	0.5612 mL	2.8061 mL	5.6121 mL	11.2243 mL	14.0304 mL
10 mM	0.2806 mL	1.403 mL	2.8061 mL	5.6121 mL	7.0152 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1224 mL	1.403 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.5612 mL	0.7015 mL

CFN97118	Phebalosin	6545-99-9	258.3	C₁₅H₁₄O₄
CFN97453	Minumicrolin	88546-96-7	276.3	C₁₅H₁₆O₅
CFN98604	Murrangatin	37126-91-3	276.3	C₁₅H₁₆O₅
CFN98826	Murrangatin diacetate	51650-59-0	360.4	C₁₉H₂₀O₇
CFN95409	Murracarpin	120786-76-7	290.3	C₁₆H₁₈O₅
CFN97451	Murraxocin	88478-44-8	304.3	C₁₇H₂₀O₅
CFN97532	Hainanmurpanin	95360-22-8	318.3	C₁₇H₁₈O₆
CFN96753	8-(1-Chloro-2-hydroxy-3-methylbut-3-enyl)-7-methoxycoumarin	131652-35-2	294.73	C₁₅H₁₅ClO₄
CFN89184	Kimcuongin	1872403-23-0	356.37	C₂₀H₂₀O₆