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    Kulactone
    Information
    CAS No. 22611-36-5 Price
    Catalog No.CFN92976Purity>=98%
    Molecular Weight452.67Type of CompoundTriterpenoids
    FormulaC30H44O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Description: Kulactone has cytotoxic effects, with IC₅₀ values of 5.6-21.2 ug/mL, it inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line.
    Targets: Antifection
    In vitro:
    Nat Prod Res. 2016 Sep;30(17):1984-7.
    Antimicrobial compounds from root, stem bark and seeds of Melia volkensii.[Pubmed: 26517430]
    Three compounds, toosendanin (1), Kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature.
    METHODS AND RESULTS:
    1 and 2, isolated for the first time from M. volkensii, exhibited significant (p < 0.05) activity against Escherichia coli with minimum inhibitory concentration of 12.5 μg/mL, close to that of neomycin (6.25 μg/mL). The compounds also exhibited high activity against Aspergillus niger (MIC 6.25 μg/mL compared to 2.5 μg/mL for clotrimazole). Dichloromethane and methanol seed, hexane stem bark and methanol root bark extracts exhibited activities towards Escherichia coli, Staphylococcus aureus, Aspergillus niger and Plasmodium falciparum, respectively.
    CONCLUSIONS:
    Antimicrobial activity of the plant towards A. niger, P. falciparum and S. aureus is reported for the first time in the current work.
    Kulactone Description
    Source: The seeds of Melia toosendan
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2091 mL 11.0456 mL 22.0911 mL 44.1823 mL 55.2279 mL
    5 mM 0.4418 mL 2.2091 mL 4.4182 mL 8.8365 mL 11.0456 mL
    10 mM 0.2209 mL 1.1046 mL 2.2091 mL 4.4182 mL 5.5228 mL
    50 mM 0.0442 mL 0.2209 mL 0.4418 mL 0.8836 mL 1.1046 mL
    100 mM 0.0221 mL 0.1105 mL 0.2209 mL 0.4418 mL 0.5523 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2002 Dec;65(12):1886-91.
    Antineoplastic agents. 489. Isolation and structures of meliastatins 1-5 and related euphane triterpenes from the tree Melia dubia.[Pubmed: 12502333 ]

    METHODS AND RESULTS:
    The bark of the giant neem tree Melia dubia was found to contain 11 euphane-type triterpenes. Five new compounds, meliastatins 1-5 (1-5), proved to inhibit growth of the P388 lymphocytic leukemia cell line (ED(50) 1.7-5.6 microg/mL). Four of the others, the previously known methyl kulonate (8), kulinone (9), 16-hydroxybutyrospermol (10), and Kulactone (11), were also found to inhibit (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. In addition, two new euphane triterpenes were isolated and named dubione A (6) and dubione B (7).
    CONCLUSIONS:
    Structures for each of the 11 euphane triterpenes were established by spectral techniques that included HRMS and 2D NMR.