Info: Read More
  • ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  •   
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Science | Nature | Cell | View More
    Natural Products
    Parishin B
    Information
    CAS No. 174972-79-3 Price $80 / 20mg
    Catalog No.CFN93113Purity>=98%
    Molecular Weight728.7Type of CompoundMiscellaneous
    FormulaC32H40O19Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $44.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Stanford University (USA)
  • Aarhus University (Denmark)
  • University of Oslo (Norway)
  • Universitas islam negeri Jakarta (Indonesia)
  • Korea Intitute of Science and T... (Korea)
  • Heinrich-Heine-University Düss... (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Agricultural Research Organizat... (Israel)
  • Anna University (India)
  • Medical University of Gdansk (Poland)
  • Ain Shams University (Egypt)
  • More...
  • Package
    Featured Products
    Chamaejasmine

    Catalog No: CFN92154
    CAS No: 69618-96-8
    Price: $463/5mg
    Kurarinone

    Catalog No: CFN92003
    CAS No: 34981-26-5
    Price: $118/20mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $ / mg
    Tanshinone IIB

    Catalog No: CFN99820
    CAS No: 17397-93-2
    Price: $463/5mg
    Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $318/5mg
    Astragalin

    Catalog No: CFN98733
    CAS No: 480-10-4
    Price: $138/20mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Vasoprotective Compound Library
  • Miscellaneous Compound Library
  • VEGFR Inhibitor Library
  • Biological Activity
    Description: Parishin B has good neuroprotective effects against brain disorders, it can prevent vascular dementia.
    Targets: VEGFR
    In vivo:
    Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2668-73.
    Study on active ingredient and mechanism in preventing vascular dementia of Tianzhusan coming from Tujia medicine.[Pubmed: 26697697]

    METHODS AND RESULTS:
    To make clear of the absorbed components of Tianzhusan (TZS) and its possible mechanism in preventing vascular dementia (VD), the rats' models of VD were prepared by a permanent ligation of the bilateral common carotid arteries. After 60 days, rats were administrated with TZS for 0.1 g x kg(-1), and the volume is 0.02 mL x g(-1). After 3 days, the medicated serum was prepared and detected by UPLC, and then we predicted the possible chemical structure of the absorbed components of TZS. According to the absorbed components, the potential targets of TZS were found by ligand profiling of Discovery Studio 3.5. All of these target genes were submitted to DAVID onine for gene set enrichment analysis (GSEA). The 5 absorbed components of TZS have been predicted, and four of them have been identified as Parishin B, parishin C, parishin, pennogenin-3-O-alpha-L-rhamnopyranosy-(1-->2)-beta-D-glucoside. Through reverse finding targets, we got 861 pharmacophore models and 9 pathways from KEGG, BIOCARTA after document verification.
    CONCLUSIONS:
    These results showed that the efficacy mechanism of TZS on VD perhaps were be related with these absorbed components and pathways. If the traditional herbs could be proved effective by efficacy tests, the serum pharmacochemistry, computer-aided drug design, system biology and other technologies can be used in the next experiments, which will be beneficial to fast discovery of material basis and mechanisms of traditional medicine coming form ethnic minorities.
    Parishin B Description
    Source: The rhizomes of Gastrodia elata
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Jaceosidin

    Catalog No: CFN90386
    CAS No: 18085-97-7
    Price: $198/20mg
    8-Prenylnaringenin

    Catalog No: CFN92016
    CAS No: 53846-50-7
    Price: $138/10mg
    Deacetyl ganoderic acid F

    Catalog No: CFN90746
    CAS No: 100665-44-9
    Price: $388/5mg
    (E)-Aldosecologanin

    Catalog No: CFN97737
    CAS No: 471271-55-3
    Price: $333/5mg
    Acanthoside B

    Catalog No: CFN97220
    CAS No: 7374-79-0
    Price: $308/10mg
    Apterin

    Catalog No: CFN95005
    CAS No: 53947-89-0
    Price: $388/10mg
    Bruceine D

    Catalog No: CFN90771
    CAS No: 21499-66-1
    Price: $258/10mg
    (-)-Gallocatechin

    Catalog No: CFN99137
    CAS No: 3371-27-5
    Price: $178/20mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3723 mL 6.8615 mL 13.7231 mL 27.4461 mL 34.3077 mL
    5 mM 0.2745 mL 1.3723 mL 2.7446 mL 5.4892 mL 6.8615 mL
    10 mM 0.1372 mL 0.6862 mL 1.3723 mL 2.7446 mL 3.4308 mL
    50 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.5489 mL 0.6862 mL
    100 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.2745 mL 0.3431 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chinese Pharmaceutical Journal, 2001 , 53 (2) :63-69.
    The contents of parishin, parishin B and parishin C in traditional decoctions and commercial extracts of Gastrodiae Rhizoma[Reference: WebLink]

    METHODS AND RESULTS:
    The contents of parishin, Parishin B and parishin C in six traditional decoctions and six commercial extracts of Gastrodiae Rhizoma were analyzed by high performance liquid chromatography. Separation and quantitation were performed on a Cosmosil 5C18-AR column by gradient elution with varied ratios of 0.1 % (v/v) phosphoric acid: methanol as the mobile phase at a flow rate of 1.0 mL/min and detection at 222 nm. Sulfamethoxypyridazine was used as the internal standard. The contents of parishin, Parishin B and parishin C in traditional decoctions of Gastrodiae Rhizoma were 2.7±0.5 mg/g, 2.3 ± 0.2 mg/g and 1.6 ± 0.3 mg/g, whereas commercial extracts contained 6.9± 0.9 mg/g, 2.7± 0.3 mg/g and 1.6± 0.1 mg/g, respectively. Based on our results, the maximum daily doses of parishin, Parishin Band parishin C in traditional decoctions of Gastrodiae Rhizoma were 24.1± 4.5 mg, 20.4± 2.0 mg and 14.4± 2.6 mg compared to 15.6± 1.4 mg, 6.5± 1.1 mg and 4.1± 0.7 mg in commercial extracts, respectively.
    CONCLUSIONS:
    The daily dose of parishin, Parishin Band parishin C were higher in traditional decoctions than in commercial extracts.
    Chinese Journal of Experimental Traditional Medical Formulae, 2016, (18) :5-8.
    Comparison on Chemical Constituents and Pharmacological Effect of Gastrodiae Rhizoma Between Traditional Processing and Integration Processing[Reference: WebLink]
    To elucidate the rationality of integration processing technology based on comparison on chemical constituents and pharmacological effect of Gastrodiae Rhizoma between traditional processing and integration processing.
    METHODS AND RESULTS:
    Taking contents of gastrodin and parishins as indexes,chemical constituents difference in Gastrodiae Rhizoma between traditional processing and integration processing was compared,effects of Gastrodiae Rhizoma on eclampsia model induced by pentylenetetrazole were observed to compare products with different processing technology. Contents of gastrodin,parishin A,Parishin B,parishin C and parishin E in products of integration processing were 0. 79%,2. 04%,0. 91%,0. 23% and0. 57%,they were 0. 39%,1. 12%,0. 64%,0. 15% and 0. 54% in products of traditional processing. The anti-eclampsia effect of Gastrodiae Rhizoma produced with integrated processing technology was better thantraditional processing technology.
    CONCLUSIONS:
    Compared with the traditional processing technology, the integrated processing technology is better in guaranteeing the quality of pieces,reducing the cost of production and increasing the production efficiency.