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    L-Theanine
    L-Theanine
    Information
    CAS No. 3081-61-6 Price $70 / 100mg
    Catalog No.CFN90429Purity>=98%
    Molecular Weight174.19Type of CompoundAlkaloids
    FormulaC7H14N2O3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    L-Theanine Description
    Source: The leaves of Camellia sinensis
    Biological Activity or Inhibitors: 1. L-Theanine heals gastric ulcer at a dose of 10 mg/kg b.w.
    2. L-Theanine can significantly alleviate the adverse oxidative effect.
    3. L-Theanine promotes relaxation and improves concentration and learning ability and has neuroprotective effects.
    4. L-Theanine prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals.
    5. L-Theanine stabilises the glutamatergic concentration in the brain, which is a possible mechanism underlying the therapeutic effect ; it has potential effect in counteracting the damage inflicted by aluminium on rat brain regions.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.7409 mL 28.7043 mL 57.4086 mL 114.8172 mL 143.5214 mL
    5 mM 1.1482 mL 5.7409 mL 11.4817 mL 22.9634 mL 28.7043 mL
    10 mM 0.5741 mL 2.8704 mL 5.7409 mL 11.4817 mL 14.3521 mL
    50 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.2963 mL 2.8704 mL
    100 mM 0.0574 mL 0.287 mL 0.5741 mL 1.1482 mL 1.4352 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    L-Theanine References Information
    Citation [1]

    Hum Exp Toxicol. 2015 Apr 7. pii: 0960327115578864.

    l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor.[Pubmed: 25852135]
    Here we evaluated the ability of L-Theanine in preventing experimental hepatic cirrhosis and investigated the roles of nuclear factor-κB (NF-κB) activation as well as transforming growth factor β (TGF-β) and connective tissue growth factor (CTGF) regulation. L-Theanine prevented increased expression of NF-κB and down-regulated the pro-inflammatory (interleukin (IL)-1β and IL-6) and profibrotic (TGF-β and CTGF) cytokines. Furthermore, the levels of messenger RNA encoding these proteins decreased in agreement with the expression levels. L-Theanine promoted the expression of the anti-inflammatory cytokine IL-10 and the fibrolytic enzyme metalloproteinase-13. Liver hydroxyproline contents and histopathological analysis demonstrated the anti-fibrotic effect of L-Theanine. In conclusion, L-Theanine prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals.
    Citation [2]

    Biotechnol Adv. 2015 May-Aug;33(3-4):335-342.

    An overview of biological production of L-theanine.[Pubmed: 25871834]
    L-Theanine (γ-glutamylethylamide) is a unique non-protein amino acid that is naturally found in tea plants. It contributes to the umami taste and unique flavor to green tea infusion, and thus its content in tea leaves highly impacts the tea quality and price. In addition to the graceful taste, it has been proved to have many beneficial physiological effects, especially promoting relaxation and improving concentration and learning ability. Based on these promising advantages, L-Theanine has been commercially developed as a valuable ingredient for use in food and beverages to improve and/or maintain human health. L-Theanine can be obtained by chemical synthesis or isolation from tea, while chemical synthesis of L-Theanine is hard to be accepted by consumers and is not allowed to use in food industry, and isolation of L-Theanine in high purity generally involves time-consuming, cost-ineffective, and complicated operational processes. Accordingly, the biological production of L-Theanine has recently attracted much attention. Four kinds of bacterial enzymes, including L-glutamine synthetase, γ-glutamylmethylamide synthetase, γ-glutamyltranspeptidase, and L-glutaminase, have been characterized to have L-Theanine-producing ability. Herein, an overview of recent studies on the biological production of L-Theanine was presented.
    Citation [3]

    Drug Chem Toxicol. 2015 Jan;38(1):22-31.

    Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain - histopathological, and biochemical approach.[Pubmed: 24654859]
    L-Theanine is an amino acid derivative primarily found in tea. L-Theanine has been reported to promote relaxation and have neuroprotective effects.Pre-treatment with L-Theanine at a dose of 200 mg/kg b.w. significantly increased the antioxidant status and activities of membrane bound enzymes and also decreased the level of LPO and the activities of marker enzymes, when compared with aluminium induced rats. Aluminium induction also caused histopathological changes in the cerebral cortex, cerebellum and hippocampus of rat brain which was reverted by pretreatment with L-Theanine. The present study clearly indicates the potential of L-Theanine in counteracting the damage inflicted by aluminium on rat brain regions.
    Citation [4]

    Acta Neuropsychiatr. 2015 Apr 21:1-6.

    Effect of l-theanine on glutamatergic function in patients with schizophrenia.[Pubmed: 25896423]
    OBJECTIVES: Glutamatergic dysfunction in the brain has been implicated in the pathophysiology of schizophrenia. Previous studies suggested that L-Theanine affects the glutamatergic neurotransmission and ameliorates symptoms in patients with schizophrenia. The aims of the present study were twofold: to examine the possible effects of L-Theanine on symptoms in chronic schizophrenia patients and to evaluate the changes in chemical mediators, including glutamate + glutamine (Glx), in the brain by using 1H magnetic resonance spectroscopy (MRS). METHOD: The subjects were 17 patients with schizophrenia and 22 age- and sex-matched healthy subjects. L-Theanine (250 mg/day) was added to the patients' ongoing antipsychotic treatment for 8 weeks. The outcome measures were the Positive and Negative Syndrome Scale (PANSS), Pittsburgh Sleep Quality Index scores and MRS results. RESULTS: There were significant improvements in the PANSS positive scale and sleep quality after the L-Theanine treatment. As for MRS, we found no significant differences in Glx levels before and after the 8 week L-Theanine treatment. However, significant correlations were observed between baseline density of Glx and change in Glx density by L-Theanine. CONCLUSIONS: Our results suggest that L-Theanine is effective in ameliorating positive symptoms and sleep quality in schizophrenia. The MRS findings suggest that L-Theanine stabilises the glutamatergic concentration in the brain, which is a possible mechanism underlying the therapeutic effect.
    Citation [5]

    J Nat Med. 2014 Oct;68(4):699-708.

    L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin.[Pubmed: 24981317]
    L-Theanine is a unique non-protein-forming amino acid present in tea [Camellia sinensis (L.) O. Kuntze]. In the present work, we evaluated the healing effect of L-Theanine on NSAID (indomethacin)-induced gastric ulcer. Histology of the stomach tissues revealed maximum ulceration on the third day after indomethacin administration (18 mg/kg, single dose p.o.) which was accompanied by increased lipid peroxidation; protein carbonylation; Th1 cytokine synthesis, and depletion of thiol, mucin, prostaglandin (PG) E, Th2 cytokine synthesis; and total antioxidant status in mice. L-Theanine healed gastric ulcer at a dose of 10 mg/kg b.w. but aggravated the ulcerated condition at a higher dose of 40 mg/kg b.w. At 10 mg/kg b.w., L-Theanine significantly alleviated the adverse oxidative effect of indomethacin through enhanced synthesis of PGE2 by modulation of cyclo-oxygenase-1 and 2 [COX-1 and COX-2] expression, Th1/Th2 cytokine balance, and restoration of cellular antioxidant status at the gastric ulcer margin. The present study revealed for the first time the dose-dependent biphasic effect of a natural neuroprotective agent, L-Theanine, on gastric ulcer disease.