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    CAS No. 573-44-4 Price
    Catalog No.CFN98964Purity> 95%
    Molecular Weight742.7 Type of CompoundLignans
    FormulaC34H46O18Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Liriodendrin Description
    Source: The herbs of Linaria vulgaris
    Biological Activity or Inhibitors: 1. Liriodendrin may be a potent suppressor of CaCl(2)-induced arrhythmias.
    2. Liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.
    3. Liriodendrin has anti-inflammatory and antinociceptive effects after oral administration , was attributable to the in vivo transformation to syringaresinol, which may function as the active constituent.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3464 mL 6.7322 mL 13.4644 mL 26.9288 mL 33.661 mL
    5 mM 0.2693 mL 1.3464 mL 2.6929 mL 5.3858 mL 6.7322 mL
    10 mM 0.1346 mL 0.6732 mL 1.3464 mL 2.6929 mL 3.3661 mL
    50 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.5386 mL 0.6732 mL
    100 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.2693 mL 0.3366 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Liriodendrin References Information
    Citation [1]

    Biomol Ther (Seoul). 2015 Jan;23(1):53-9.

    Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury.[Pubmed: 25593644]
    In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using Liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 μM. It was also exhibited acid-neutralizing capacity (10.3%) and H(+)/K(+)-ATPase inhibition of 42.6% (500 μM). In pylorus-ligated rats, Liriodendrin showed lower volume of gastric juice (4.38 ± 2.14 ml), slightly higher pH (1.53 ± 0.41), and smaller total acid output (0.47 ± 0.3 mEq/4 hrs) than the control group. Furthermore Liriodendrin inhibited colonization of H. pylori effectively. In vivo test, Liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that Liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.
    Citation [2]

    Arch Pharm Res. 2010 Dec;33(12):1927-32.

    A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx.[Pubmed: 21191756]
    A new triterpene, 21-O-senecioyl-R(1)-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, Liriodendrin (2), was tested on a model of CaCl(2)-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of Liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of Liriodendrin from 87.5% to 25%. The antiarrhythmic effect of Liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, Liriodendrin may be a potent suppressor of CaCl(2)-induced arrhythmias.
    Citation [3]

    Planta Med. 2003 Jul;69(7):610-6.

    In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus.[Pubmed: 12898415]
    In the present study, Liriodendrin isolated by activity-guided fractionation from the ethyl acetate (EtOAc) extracts of the stem bark of Acanthopanax senticosus, was evaluated for anti-inflammatory and antinociceptive activities. Liriodendrin (5, 10 mg/kg/day, p. o.) significantly inhibited the increase of vascular permeability induced by acetic acid in mice and reduced an acute paw edema induced by carrageenan in rats. When the analgesic activity was measured by the acetic acid-induced writhing test and hot plate test, Liriodendrin showed a dose-dependent inhibition in animal models. In addition, syringaresinol, the hydrolysate of Liriodendrin, more potently inhibited the LPS-induced production of NO, PGE 2 and TNF-alpha production of macrophages than Liriodendrin. Consistent with these observations, the expression level of iNOS and COX-2 enzyme was decreased by syringaresinol in a concentration-dependent manner. These results suggest that the anti-inflammatory and antinociceptive effects of Liriodendrin after oral administration were attributable to the in vivo transformation to syringaresinol, which may function as the active constituent.
    Citation [4]

    Arch Pharm Res. 1999 Feb;22(1):30-4.

    Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation to in vitro cytotoxicity.[Pubmed: 10071956]
    When Liriodendrin or syringin was incubated for 24 h with human intestinal bacteria, two metabolites, (+)-syringaresinol-beta-D-glucopyranoside and (+)-syringaresinol, from Liriodendrin and one metabolite, synapyl alcohol, from syringin were produced. The metabolic time course of Liriodendrin was as follows: at early time, Liriodendrin was converted to (+)-syringaresinol-beta-D-glucopyranoside, and then (+)-syringaresinol. The in vitro cytotoxicities of these metabolites, (+)-syringaresinol and synapyl alcohol, were superior to those of Liriodendrin and syringin.