ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
International Journal of Pharmacognosy.2015 7(1).Biochem Systematics and EcologyOctober 2017;Food Analytical Methods07 April 2017Molecules. 2017 Feb 8;Cell Physiol Biochem.2017;43(4):1425-1435.
Molecules.2017 Oct 27;Evidence-Based Comp. & Alter. Med.Dec. 27, 2015Phytomedicine2015 March 20.Invest New Drugs. 2017 Apr;Int J Mol Sci.2015 Jan 6;16(1):1232-51.
Phytother Res.2018 Jan 29.Arch Toxicol. 2017 Mar 20. Tumour Biol.2015 Apr 12.Hum Exp Toxicol. 2016 Dec 9.
Our products had been exported to the following research institutions and universities, And still growing.
Martin Luther University of Hall... (Germany)Fraunhofer-Institut für Molekul... (Germany)National Research Council of Can... (Canada)University of Bonn (Germany)
Pennsylvania State University (USA)The Vancouver Prostate Centre (V... (Canada)Gyeongsang National University (Korea)University of Ioannina (Greece)
University Medical Center Mainz (Germany)Almansora University (Egypt)Max Rubner-Institut (MRI) (Germany)
||1. Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.|
2. Mirabijalone D inhibits Aβ1–42 production by 43.7% in APPSW-N2a cells.
Mirabijalone D Description
||The herbs of Mirabilis jalapa
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Mirabijalone D References Information
Bioorganic & Medicinal Chemistry Letters.2014 Jul1;24(13):2945–2948.
|β-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.[Reference: WebLink]|
|Suspension cultures of Abronia nana were established to produce C-methylisoflavones. A new C-methylrotenoid, named abronione A (2), was isolated along with three known rotenoids, boeravinone D (1), boeravinone A methyl ether (3), and Mirabijalone D (4). The IC50 values of compounds 1, 2, and 4 on β-secretase (BACE1) were 4.77, 62.21, and 4.24 μM, respectively, whereas 3 was inactive. At concentrations up to 1.0 mM, the compounds did not inhibit other proteases such as trypsin, chymotrypsin, and elastase, indicating that they were specific inhibitors of β-secretase. Compounds 1 and Mirabijalone D were non-competitive inhibitors based on the Dixon plot and with Ki values of 5.01 and 4.28 μM, respectively. At 50 μM, Mirabijalone D inhibited Aβ1–42 production by 43.7% in APPSW-N2a cells.