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Mirabijalone D
Mirabijalone D
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Mirabijalone D
Price:
CAS No.: 485811-84-5
Catalog No.: CFN96173
Molecular Formula: C18H14O7
Molecular Weight: 342.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Mirabilis jalapa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1–42 production by 43.7% in APPSW-N2a cells.
Targets: Beta Amyloid
Mirabijalone D Description
Source: The herbs of Mirabilis jalapa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9214 mL 14.6071 mL 29.2141 mL 58.4283 mL 73.0353 mL
5 mM 0.5843 mL 2.9214 mL 5.8428 mL 11.6857 mL 14.6071 mL
10 mM 0.2921 mL 1.4607 mL 2.9214 mL 5.8428 mL 7.3035 mL
50 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.1686 mL 1.4607 mL
100 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.5843 mL 0.7304 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Bioorganic & Medicinal Chemistry Letters.2014 Jul1;24(13):2945–2948.
β-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.[Reference: WebLink]

METHODS AND RESULTS:
Suspension cultures of Abronia nana were established to produce C-methylisoflavones. A new C-methylrotenoid, named abronione A (2), was isolated along with three known rotenoids, boeravinone D (1), boeravinone A methyl ether (3), and Mirabijalone D (4). The IC50 values of compounds 1, 2, and 4 on β-secretase (BACE1) were 4.77, 62.21, and 4.24 μM, respectively, whereas 3 was inactive. At concentrations up to 1.0 mM, the compounds did not inhibit other proteases such as trypsin, chymotrypsin, and elastase, indicating that they were specific inhibitors of β-secretase.
CONCLUSIONS:
Compounds 1 and Mirabijalone D were non-competitive inhibitors based on the Dixon plot and with Ki values of 5.01 and 4.28 μM, respectively. At 50 μM, Mirabijalone D inhibited Aβ1–42 production by 43.7% in APPSW-N2a cells.
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CAS No: 13161-75-6
Price: $188/20mg
Quercetin 3-O-malonylglucoside

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CAS No: 96862-01-0
Price: $238/5mg
Aerugidiol

Catalog No: CFN92621
CAS No: 116425-35-5
Price: $318/5mg
Crocin I

Catalog No: CFN99927
CAS No: 94238-00-3
Price: $100/20mg
(+)-Isocorynoline

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CAS No: 475-67-2
Price: $138/20mg
Cinnamic acid

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CAS No: 140-10-3
Price: $30/20mg
8-Prenylkaempferol

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CAS No: 28610-31-3
Price: $ / mg
1-Dehydro-10-gingerdione

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Price: $ / mg
Gambogic acid

Catalog No: CFN90172
CAS No: 2752-65-0
Price: $30/20mg
Luteollin 5-glucoside

Catalog No: CFN98568
CAS No: 20344-46-1
Price: $ / mg
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