• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Voacangine
    Voacangine
    Information
    CAS No. 510-22-5 Price $463 / 5mg
    Catalog No.CFN92252Purity>=98%
    Molecular Weight368.5Type of CompoundAlkaloids
    FormulaC22H28N2O3Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Anna University (India)
  • University of Virginia (USA)
  • University of Sao Paulo (Brazil)
  • Universidad de Antioquia (Colombia)
  • Institute of Chinese Materia Med... (China)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Korea Institute of Oriental Medi... (Korea)
  • Universita' Degli Studi Di Cagli... (Italy)
  • University of Amsterdam (Netherlands)
  • University of Lodz (Poland)
  • Institute of Bioorganic Chemistr... (Poland)
  • More...
  • Package
    Featured Products
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Salviolone

    Catalog No: CFN92163
    CAS No: 119400-86-1
    Price: $595/5mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $268/10mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Butyrospermol

    Catalog No: CFN92376
    CAS No: 472-28-6
    Price: $388/5mg
    Voacangine Description
    Source: The herbs of Ervatamia heyneana
    Biological Activity or Inhibitors: 1. Voacangine is a novel transient receptor potential vanilloid type 1 (TRPV1) antagonist.
    2. Voacangine shows mod. cytotoxic activity, also some CNS, brachycardial and hypotensive action.
    3. Voacangine significantly suppresses in vitro angiogenesis, such as VEGF-induced tube formation and chemoinvasion.
    4. Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50, 9 μM), but it shows noncompetitive inhibition against icilin (IC50, 7 μM), it may contribute to the development of a novel class of stimulus-selective TRPM8 blockers.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Glyasperin C

    Catalog No: CFN95065
    CAS No: 142474-53-1
    Price: $333/5mg
    3,4-O-dimethylcedrusin

    Catalog No: CFN95026
    CAS No: 166021-14-3
    Price: $388/10mg
    Gelidoside

    Catalog No: CFN89019
    CAS No: 128420-44-0
    Price: $288/10mg
    Columbianetin acetate

    Catalog No: CFN90510
    CAS No: 23180-65-6
    Price: $238/20mg
    Epimedin B1

    Catalog No: CFN95017
    CAS No: 133137-58-3
    Price: $268/5mg
    Pinoresinol 4-O-beta-D-glucopyrano...

    Catalog No: CFN97180
    CAS No: 69251-96-3
    Price: $298/20mg
    (R)-Reticuline

    Catalog No: CFN95013
    CAS No: 3968-19-2
    Price: $318/10mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7137 mL 13.5685 mL 27.137 mL 54.2741 mL 67.8426 mL
    5 mM 0.5427 mL 2.7137 mL 5.4274 mL 10.8548 mL 13.5685 mL
    10 mM 0.2714 mL 1.3569 mL 2.7137 mL 5.4274 mL 6.7843 mL
    50 mM 0.0543 mL 0.2714 mL 0.5427 mL 1.0855 mL 1.3569 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5427 mL 0.6784 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Voacangine References Information
    Citation [1]

    J Nat Prod. 2014 Feb 28;77(2):285-97.

    Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.[Pubmed: 24484240]
    Voacangine (1) is an alkaloid found in the root bark of Voacanga africana. Our previous work has suggested that Voacangine is a novel transient receptor potential vanilloid type 1 (TRPV1) antagonist. In this study, the agonist and antagonist activities of Voacangine were examined against thermosensitive TRP channels. Channel activity was evaluated mainly using TRP channel-expressing HEK cells and calcium imaging. Herein, it was shown that Voacangine acts as an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50, 8 μM). The compound competitively blocked capsaicin binding to TRPV1 (IC50, 50 μM). Voacangine (1) competitively inhibited the binding of menthol to TRPM8 (IC50, 9 μM), but it showed noncompetitive inhibition against icilin (IC50, 7 μM). Accordingly, Voacangine may contribute to the development of a novel class of stimulus-selective TRPM8 blockers
    Citation [2]

    Biochem Biophys Res Commun. 2012 Jan 6;417(1):330-4.

    A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo.[Pubmed: 22155252]
    Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a critical role in normal and pathological phenotypes, including solid tumor growth and metastasis. Accordingly, the development of new anti-angiogenic agents is considered an efficient strategy for the treatment of cancer and other human diseases linked with angiogenesis. We have identified Voacangine, isolated from Voacanga africana, as a novel anti-angiogenic agent. Voacangine inhibits the proliferation of HUVECs at an IC(50) of 18 μM with no cytotoxic effects. Voacangine significantly suppressed in vitro angiogenesis, such as VEGF-induced tube formation and chemoinvasion. Moreover, the compound inhibits in vivo angiogenesis in the chorioallantoic membrane at non-toxic doses. In addition, Voacangine decreased the expression levels of hypoxia inducible factor-1α and its target gene, VEGF, in a dose-dependent manner. Taken together, these results suggest that the naturally occurring compound, Voacangine, is a novel anti-angiogenic compound.