13-Oxyingenol dodecanoat | CAS:54706-70-6

13-Oxyingenol dodecanoat

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Description:

13-Oxyingenol dodecanoat shows moderate cytotoxicity with IC50 values being 35.59 ± 5.37 μmol·L-1 (Caco-2), 24.04 ± 4.70 μmol·L-1 (MCF-7), and 22.24 ± 5.19 μmol·L-1 (MCF-7/ADM).

In vitro:

Chin J Nat Med. 2016 Dec;14(12):939-945.

Regio- and stereo-selective hydroxylations of ingenane diterpenoids by Mortierella ramanniana and Gibberella fujikuroi.[Pubmed: 28262122 ]

The regio- and stereo-selective hydroxylations of two ingenane diterpenoids, 20-deoxyingenol (1) and 13-Oxyingenol dodecanoat (2), by the filamentous fungi Mortierella ramanniana and Gibberella fujikuroi were investigated in the present study.
METHODS AND RESULTS:
Four undescribed metabolites (3-6) of substrate 1 and two undescribed metabolites (7 and 8) of substrate 2 were isolated. All the metabolites were identified as hydroxylated ingenane derivatives by extensive NMR and HR-ESI-MS data analyses. All the biotransformed compounds and the substrates were evaluated for their cytotoxicities against three human cancer cell lines, including human colon cancer Caco-2, breast cancer MCF-7, and adriamycin (ADM)-resistant MCF-7/ADM cell lines. All ingenane alcohols (1, and 3-6) displayed no significant cytotoxic activities. The substrate 13-Oxyingenol dodecanoat (2) showed moderate cytotoxicity with IC50 values being 35.59 ± 5.37 μmol·L-1 (Caco-2), 24.04 ± 4.70 μmol·L-1 (MCF-7), and 22.24 ± 5.19 μmol·L-1 (MCF-7/ADM). However, metabolites 7 and 8 displayed no significant cytotoxicity.
CONCLUSIONS:
These results indicated that the hydroxylation at the C-13 aliphatic acid ester of substrate 2 can significantly reduce the cytotoxic activity.

13-Oxyingenol dodecanoat Description

Source:	The seeds of Euphorbia lathyris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	13-Oxyingenol dodecanoat
Price:
CAS No.:	54706-70-6
Catalog No.:	CFN93244
Molecular Formula:	C₃₂H₅₀O₇
Molecular Weight:	546.74 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The seeds of Euphorbia lathyris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.829 mL	9.1451 mL	18.2902 mL	36.5805 mL	45.7256 mL
5 mM	0.3658 mL	1.829 mL	3.658 mL	7.3161 mL	9.1451 mL
10 mM	0.1829 mL	0.9145 mL	1.829 mL	3.658 mL	4.5726 mL
50 mM	0.0366 mL	0.1829 mL	0.3658 mL	0.7316 mL	0.9145 mL
100 mM	0.0183 mL	0.0915 mL	0.1829 mL	0.3658 mL	0.4573 mL

CFN92864	3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol	158850-76-1	540.7	C₃₂H₄₄O₇
CFN92868	3-O-(2'E,4'E-Decadienoyl)ingenol	466663-11-6	498.7	C₃₀H₄₂O₆
CFN92865	3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol	466663-12-7	540.7	C₃₂H₄₄O₇
CFN89409	Ingenol 3-palmitate	52557-26-3	586.84	C₃₆H₅₈O₆
CFN89401	Ingenol 20-palmitate	39071-33-5	586.84	C₃₆H₅₈O₆
CFN93244	13-Oxyingenol dodecanoat	54706-70-6	546.74	C₃₂H₅₀O₇
CFN90367	12-O-tetradecanoylphorbol-13-acetate	16561-29-8	616.83	C₃₆H₅₆O₈
CFN96233	Euphohelioscopin A	87064-61-7	498.7	C₃₀H₄₂O₆
CFN95325	Lathyranoic acid A	850560-44-0	494.6	C₂₉H₃₄O₇
CFN92867	3-O-(2'E,4'Z-Decadienoyl)ingenol	84680-59-1	498.7	C₃₀H₄₂O₆