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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Breast Cancer.2015, 18(2):112-118Phytochemistry.2017, 141:162-170Tropical J. of Pha. Research...2017...Biol Pharm Bull.2017, 40(6):797-806Chem Pharm Bull (Tokyo)....2017...Sci Rep.2017, 7:46299J Pharm Biomed Anal.2018, 151:32-41Phys Chem Chem Phys....2018...
Molecules.2018, 23(3):E615J Herbmed Pharmacol.2018, 7(4):280-286Planta Med.2018, 84(6-07):465-474APMIS.2019, 127(10):688-695J Ethnopharmacol.2019, 236:31-41Food Chem.2020, 313:126079Metabolites.2020, 11(1):E11.BMC Plant Biol.2020, 20(1):214.
J Ethnopharmacol.2020, 260:112988.Acta Edulis Fungi2020, 27(02):63-76.Medicina (Kaunas).2020, 56(12):685.Korean Herb. Med. Inf....2020...Analytical Letters.2020, doi 10.1008Natural Product Communications...2020...Inflammation.2021, doi: 10.1007
Our products had been exported to the following research institutions and universities, And still growing.
Deutsches Krebsforschungszentrum (Germany)Lund University (Sweden)Universidad Industrial de Santa... (Colombia)University of Melbourne (Australia)
Colorado State University (USA)Universiti Kebangsaan Malaysia (Malaysia)Monash University (Australia)University of Maryland (USA)
Wageningen University (Netherlands)Mahidol University (Thailand)Kitasato University (Japan)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083Drug Des Devel Ther.2020, 14:5189-5204.The Korea Journal of Herbology2020, 35(3):33-45. Int J Mol Sci.2019, 21(1):E265Molecules.2020, 25(9):2081.Br J Pharmacol.2016, 173(2):396-410Biomedicines.2020, 8(11):486.Environ Toxicol.2020, doi: 10.1002Appl. Sci.2020, 10(8),2804Chemistry of Plant Materials.2016, 33-46
Related Screening Libraries
||trans-2,3-Bis(3,4-dimethoxybenzyl)-gamma-butyrolactone is capable of inhibiting Na+,K+-ATPase activity with IC50 at a concentration less than 5 x 10(-4) M, it also shows [3H]ouabain displacement activity with IC50 at a concentration of 10(-4)-10(-3) M.|
||Sodium Channel | ATPase | Potassium Channel|
|Res Commun Chem Pathol Pharmacol. 1989 May;64(2):227-40. |
|Endogenous digoxin-like activity of mammalian-lignans and their derivatives.[Pubmed: 2544967]|
|A comparative study was made on the endogenous digoxin-like activity of sixteen mammalian-type lignan derivatives including enterolactone and enterodiol.
METHODS AND RESULTS:
Cross-reactivity to antidigoxin antibody, inhibition of dog kidney Na+,K+-ATPase, and ouabain displacing activity against [3H]ouabain binding to human erythrocytes on the part of these derivatives were examined and compared in all cases with that of ouabain. meso-2,3-Dibenzylbutane-1,4-diol (meso-HA-1) was found to possess the most potent cross-reactivity to antidigoxin antibody. Several lignans, particularly HA-1 (either meso or dl), dl-2,3-bis(3-methoxybenzyl)butane-1,4-diol(HA-4), dl-2,3-bis(3,4-dimethoxybenzyl)butane-1,4-diol(HA-10), dl-2,3-bis(3,4-dimethoxybenzyl)-1,4-dimethoxybutane(HA-11), and trans-2,3-bis(3,4-dimethoxybenzyl)-gamma-butyrolactone(HA-14) were capable of inhibiting Na+,K+-ATPase activity with IC50 at a concentration less than 5 x 10(-4) M. Meso-HA-1, HA-11 and HA-14 also showed [3H]ouabain displacement activity with IC50 at a concentration of 10(-4)-10(-3) M. These determinations of activity were made at doses 100-1000 times those of ouabain.
The synthetic lignans are considered to derive in vivo from plant material usually present in fibrous food. Based on the data obtained, some lignans may possibly be endogenous digitalis-like substances.
||The barks of Pseudolarix kaempferi
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Tetrahedron: Asymmetry.1998 August;9(16):2827–2831. |
|A chemoenzymatic synthesis of both enantiomers of a cis-lignan lactone.[Reference: WebLink]|
METHODS AND RESULTS:
The stereoselective acetylation of meso-2,3-bis(3,4-dimethoxybenzyl)butanediol by vinyl acetate in the presence of Candida antarctica lipase in benzene gave the corresponding (+)-(2S,3R) monoester (ee ≥98%). Transesterification of meso-2,3-bis(3,4-dimethoxybenzyl)butyl diacetate, in the presence of the same enzyme, by ethanol in benzene/isopropyl ether gave the corresponding (−)-(2R,3S) monoester (ee ≥98%).
Both enantiomers of the known cis-2,3-Bis(3,4-dimethoxybenzyl)butyrolactone were synthesized from these monoesters.