ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $351.1 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Biosci. Rep.2020, 10.1024Int J Mol Sci.2015, 16(1):1232-51PLoS One.2018, 13(3):e0193386Natural Product Communications...2020...Phytother Res.2016, 30(12):2020-2026Int J Mol Med.2016, 37(2):501-8New Zealand J. Forestry Sci.2014, 44:17Chem Biol Interact.2019, 298:1-7
Asian J of Pharmaceutical&Clinica...2018...Environ Toxicol.2019, 34(12):1354-1362Front Pharmacol.2019, 10:1355Heliyon2020, 6(6):e04337.Process Biochemistry2019, 85:106-115Molecules.2019, 24(19):E3417Molecules.2021, 26(4):1084.Antimicrob Agents Chemother....2020...
Appl. Sci.2020, 10(20),7374.Int J Mol Sci.2021, 22(16):8641.Antioxidants (Basel).2020, 9(7):581.Agronomy2020, 10(3),388.Int J Mol Sci.2021, 22(16):8604.University of Central Lancashire...2017...Sci Rep.2021, 11(1):10931.
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Our products had been exported to the following research institutions and universities, And still growing.
University of Toronto (Canada)Massachusetts General Hospital (USA)Research Unit Molecular Epigene... (Germany)Aarhus University (Denmark)
Chinese University of Hong Kong (China)University of Toulouse (France)Auburn University (USA)Regional Crop Research Institute (Korea)
Institute of Tropical Disease U... (Indonesia)Yale University (USA)University of Bordeaux (France)
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20-Deoxocarnosol
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2017, 22(2)Horticulturae2020, 6(4),76.Heinrich Heine University Dusseldorf2021, 62203.J Food Sci Technol.2019, 56(5):2712-2720Food Sci Biotechnol.2021, 30(2):217-226.Life Sci.2019, 216:259-270Phytochemistry.2021, 181:112539. J Food Sci Technol.2022, 59(1):212-219.LWT2020, 124:109163Korean J of Medicinal Crop Science2018, 220-226
Related Screening Libraries
| Description: |
20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity. |
| Targets: |
ROS | Antifection |
| In vitro: |
| Nat. Prod. Lett., 2002, 16(4):277-81. | | Antioxidant capacity of abietanes from Sphacele salviae.[Pubmed: 12168765 ] |
METHODS AND RESULTS:
Carnosol 1, rosmanol 2, carnosic acid 3 and 20-Deoxocarnosol 4, the main phenolic abietanes present in aerial parts of the Chilean medicinal plant Sphacele salviae were tested for antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).
CONCLUSIONS:
All compounds displayed higher antioxidant levels than BHT under the same conditions and carnosic acid was more efficient than vitamin E. | | Int. J. Mol. Sci., 2014, 15(5):8360-71. | | In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr.[Pubmed: 24823881 ] | Chromatographic separation of the n-hexane extract of the aerial part of Plectranthus barbatus led to the isolation of five abietane-type diterpenes: dehydroabietane (1); 5,6-didehydro-7-hydroxy-taxodone (2); taxodione (3); 20-Deoxocarnosol (4) and 6α,11,12,-trihydroxy-7β,20-epoxy-8,11,13-abietatriene (5).
METHODS AND RESULTS:
The structures were determined using spectroscopic methods including one- and two-dimensional NMR methods. Compounds (1)-(3) and (5) are isolated here for the first time from the genus Plectranthus. The isolated abietane-type diterpenes tested in vitro for their antiprotozoal activity against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against fibroblast cell line MRC-5.
CONCLUSIONS:
Compound (2) 5,6-didehydro-7-hydroxy-taxodone showed remarkable activity with acceptable selectivity against P. falciparum (IC50 9.2 μM, SI 10.4) and T. brucei (IC50 1.9 μM, SI 50.5). Compounds (3)-(5) exhibited non-specific antiprotozoal activity due to high cytotoxicity. Compound (1) dehydroabietane showed no antiprotozoal potential. |
|
20-Deoxocarnosol Description
| Source: |
The herbs of Salvia yunnanensis |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.1606 mL |
15.8028 mL |
31.6056 mL |
63.2111 mL |
79.0139 mL |
| 5 mM |
0.6321 mL |
3.1606 mL |
6.3211 mL |
12.6422 mL |
15.8028 mL |
| 10 mM |
0.3161 mL |
1.5803 mL |
3.1606 mL |
6.3211 mL |
7.9014 mL |
| 50 mM |
0.0632 mL |
0.3161 mL |
0.6321 mL |
1.2642 mL |
1.5803 mL |
| 100 mM |
0.0316 mL |
0.158 mL |
0.3161 mL |
0.6321 mL |
0.7901 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
