ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Cancers (Basel).2021, 13(6):1432.Biochem Systematics and Ecology...2017...J Nat Med.2020, 74(3):550-560.Molecules.2015, 20(10):19172-88Food Engineering Progress...2019...Oxid Med Cell Longev2020, 12RSC Advances2017, 86Pharmacognosy Journal....2020...
Biol Pharm Bull.2018, 41(1):65-72Onco Targets Ther.2017, 10:3467-3474Korean J. of Horticultural Sci. &...2017...Evid Based Complement Alternat Me...2016...Pak J Pharm Sci.2018, 31:311-315Toxicol Appl Pharmacol....2022...J Drug Target.2016, 24:1-28Biochem Biophys Res Commun....2020...
J Mol Histol.2019, 50(4):343-354Front Plant Sci.2017, 8:723Int J Mol Sci.2021, 22(21):11447.J Food Biochem.2019, 43(9):e12970Cell Biochem Funct.2018, 36(6):303-311Biosci Biotechnol Biochem....2020...Iranian J. Pharm. Res.2021, 20(4):59-70
Our products had been exported to the following research institutions and universities, And still growing.
Anna University (India)Uniwersytet Jagielloński w Kra... (Poland)Chulalongkorn University (Thailand)National Research Council of Ca... (Canada)
Shanghai Institute of Biochemis... (China)Johannes Gutenberg University M... (Germany)Kyung Hee University (Korea)Universidade Federal de Goias (... (Brazil)
University of Pretoria (South Africa)University of Bonn (Germany)CSIRO - Agriculture Flagship (Australia)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Antioxidants (Basel).2020, 9(2): E119Applied Biological Chemistry2020, 63:33(2020)Journal of Ginseng Research2021, 15 June.Antioxidants (Basel).2021, 10(1):112. Int J Mol Sci.2018, 19(9):E2825Int Immunopharmacol.2021, 101(Pt A):108181.J Drug Delivery Science and Tech.2022, 67:102957.Molecules.2020, 25(3):734Chemistry of Vegetable Raw Materials2019, 3:119-127J Agric Food Chem.2020, 68(51):15164-15175
Related Screening Libraries
||Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.|
||PDE | IL Receptor | TNF-α|
|Planta Med.,2007,73(11):1156-62. |
|Potent suppressive effects of 3-O-methylquercetin 5,7,3',4'-O-tetraacetate on ovalbumin-induced airway hyperresponsiveness.[Pubmed: 17823872 ]|
|We investigated the suppressive effects of 3-O-methylquercetin 5,7,3',4'- O-tetraacetate (QMTA), a more-potent phosphodiesterase (PDE)3/4 inhibitor than quercetin 3-O-methyl ether (3-MQ), which has been reported to have the potential for treating asthma, against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR). The IC50 value of QMTA for PDE3 was significantly less than that for PDE4.
METHODS AND RESULTS:
According to the Lineweaver-Burk analysis, QMTA (1-10 microM) competitively inhibited PDE3 and PDE4 activities. The Ki values were 0.9+/-0.3 (n=5) and 3.9+/-0.5 (n=5) microM, respectively, which significantly differed from each other, suggesting that QMTA has higher affinity for PDE3 than for PDE4. QMTA (3-10 microM) concentration-dependently relaxed the baseline level, and significantly inhibited cumulative OVA (10-100 microg/mL)-induced contractions in isolated sensitized guinea pig trachealis suggesting that QMTA has bronchodilator and inhibiting effects on mast cell degranulation. After the secondary challenge, the AHR was measured in unrestrained OVA-sensitized mice, with nebulized methacholine (MCh, 6.25-50 mg/mL), by barometric plethysmography using a whole-body plethysmograph. In the present results, QMTA (3-10 micromol/kg, I. P.) dose-dependently attenuated the enhanced pause (Penh) value induced by MCh (25-50 mg/mL). QMTA (3-10 micromol/kg, I. P.) also significantly inhibited total inflammatory cells, macrophages, neutrophils, lymphocytes, and eosinophils in BALF after determination of Penh values. It also significantly suppressed the release of interleukin (IL)-2, IL-4, IL-5, IFN-gamma, and TNF-alpha, with the exception that 3 micromol/kg QMTA did not suppress the releases of IL-5. QMTA even at 1 micromol/kg significantly inhibited eosinophils, IL-2, and TNF-alpha.
In conclusion, our results strongly suggest that QMTA has greater potential than 3-MQ for the treatment of asthma.
3-O-Methylquercetin tetraacetate Description
||The herbs of Croton cascarilloides
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.