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    Natural Products
    4-Methoxycoumarine
    4-Methoxycoumarine
    Information
    CAS No. 20280-81-3 Price $158 / 20mg
    Catalog No.CFN94403Purity>=98%
    Molecular Weight176.17Type of CompoundCoumarins
    FormulaC10H8O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $36.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    4-Methoxycoumarine

    4-Methoxycoumarine
    Product Name 4-Methoxycoumarine
    CAS No.: 20280-81-3
    Catalog No.: CFN94403
    Molecular Formula: C10H8O3
    Molecular Weight: 176.17 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Source: The herbs of Guazuma ulmifolia
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $158 / 20mg
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  • Phytomedicine.2021, 2(82):153452
  • South African J of Botany2020, 135:50-57
  • Front Cell Dev Biol.2020, 8:32.
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Int J Mol Sci.2018, 19(2)
  • PLoS One.2015, 10(5):e0127060
  • J Pharm Biomed Anal.2018, 151:32-41
  • Food Chem.2019, 279:80-87
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Coumarins Compound Library
  • Biological Activity
    Description: 4-Methoxycoumarin has antitumour effects.
    In vitro:
    Melanoma Research, 1999, 9(3):243-248.
    Cytostatic activity of coumarin metabolites and derivatives in the B16-F10 murine melanoma cell line.[Reference: WebLink]
    Coumarin has antitumour effects in vivo and cytostatic effects in vitro. Its half-life in humans is short (1-1.5 h) and the monohydroxylated biotransformation products have significantly longer half-lives. One or several of these products may thus be responsible for the antitumoral effects.
    METHODS AND RESULTS:
    We have assayed the in vitro cytostatic activity of five monohydroxylated coumarins (3-, 4-, 6-, 7- and 8-monohydroxycoumarin), their acetates and methyl-ethers. Murine melanoma cells (cell line B16-F10) and murine fibroblasts (B82) were exposed to the test compounds at concentrations between 10 and 160 microg/ml. The cytostatic effects were estimated by reduction of the tetrazolium dye MTT. In the melanoma cells, some of the compounds inhibited growth after exposure for 1 day. In contrast, coumarin inhibited growth to a smaller extent, and only after exposure for 3 days. The most active compounds (3-acetoxycoumarin, 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin), as well as coumarin, were also assayed in murine fibroblasts.
    CONCLUSIONS:
    The cytostatic effects of 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin were less pronounced in fibroblasts than in melanoma cells. Our observations suggest that these compounds may have a greater therapeutic margin.
    4-Methoxycoumarine Description
    Source: The herbs of Guazuma ulmifolia
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6763 mL 28.3817 mL 56.7634 mL 113.5267 mL 141.9084 mL
    5 mM 1.1353 mL 5.6763 mL 11.3527 mL 22.7053 mL 28.3817 mL
    10 mM 0.5676 mL 2.8382 mL 5.6763 mL 11.3527 mL 14.1908 mL
    50 mM 0.1135 mL 0.5676 mL 1.1353 mL 2.2705 mL 2.8382 mL
    100 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.1353 mL 1.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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