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|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Research Square2021, March 3rd.Neurotox Res.2022, 40(6):1937-1947. Appl. Sci. 2021, 11(1),14.Bioorg Med Chem.2018, 26(14):4201-4208Oncology Letters2018, 4690-4696J Pharm Biomed Anal.2019, 164:119-127J Agric Food Chem....2020...Plants (Basel).2020, 9(11):1535.
Molecules.2018, 23(7):E1817In Vitro Cellular & Developmental...2021...Acta Pharm Sin B.2015, 5(4):323-9.J Nat Med.2018, 72(3):734-744Phytochemistry.2017, 141:162-170Drug Chem Toxicol.2020, 1-12.Journal of Plant Growth Regulatio...2022...J Microbiol Biotechnol....2020...
Int Immunopharmacol.2021, 100:108073. Sci Rep.2017, 7:40345Chemistry of Plant Materials....2016...Nutrients.2018, 10(7)Planta Med.2022, 88(9-10):794-804.Plant Foods Hum Nutr.2020, 10.1007Heliyon.2022, 8(12):e12031.
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National Research Council of Ca... (Canada)Cancer Research Initatives Foun... (Malaysia)Universidade de Franca (Brazil)Biotech R&D Institute (USA)
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Plants (Basel).2021, 10(6):1192. Curr Res Virol Sci.2022, 3:100019.Evid Based Complement Alternat Med.2020, 2020:9416962.Journal of Ginseng Research2021, 15 June.J Med Food.2021, 24(3):209-217.Korean J Dent Mater2020, 47(2):63-70.Evid Based Complement Alternat Med.2022, 2022:1307173. Mol Pharm.2018, 15(8):3285-3296Pharmaceutics.2022, 14(12):2765.Preprints2021, doi:10.20944
Related Screening Libraries
|| 5,5'-Dimethoxylariciresinol-4'-O-beta-D-glucoside is shown to effectively enhance chemosensitivity of resistant cells, which makes it may be a suitable candidate for potential multidrug resistance (MDR)-reversing agents.|
|Indian J. Pharmacol.,2013,45(6):597-602. |
|Reversal of multidrug resistance by 5,5'-dimethoxylariciresinol-4-O-β-D-glucoside in doxorubicin-resistant human leukemia K562/DOX.[Pubmed: 24347768 ]|
|The objective of this study was to investigate the reversal effects of 5,5’-dimethoxylariciresinol-4’-O-β-D-glucoside (5,5'-Dimethoxylariciresinol 4-O-glucoside,DMAG) extracted from traditional Chinese medicines Mahonia on multidrug resistance (MDR) of human leukemia cells to chemotherapeutic agents.
METHODS AND RESULTS:
MTT(3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was performed to determine the effect of DMAG on doxorubicin sensitivity to K562/DOX cells. Propidium iodide /Hoechst 33342 double staining assay was used to investigate the effect of DMAG on doxorubicin-induced cellular apoptosis. Intracellular accumulation of doxorubicin and rhodamine 123 assay were performed to evaluate the effect of DMAG on drugs efflux activity of P-glycoprotein.DMAG significantly enhanced the doxorubicin cytotoxicity to K562/DOX cells. In the presence of 1.0 μM of DMAG, the IC50 of doxorubicin decreased from 34.93 ± 1.37 μM to 12.51 ± 1.28 μM. DMAG of 1.0 μM significantly enhanced doxorubicin-induced cell apoptosis in K562/DOX cells and the enhancement was time-dependent. A significant increase in accumulation of doxorubicin in the presence of DMAG was observed. After treatment of the K562/DOX cells for 1 h with 15.0 μM doxorubicin alone, the fluorescence intensity was 33093.12. With the addition of 1.0 μM of DMAG, the fluorescence intensity of doxorubicin was 2.3-fold higher. A significant increase of accumulation of rhodamine 123 in the presence of DMAG was also observed. With the addition of 1.0 μM of DMAG, the fluorescence intensity was increased by 49.11% compared with rhodamine 123 alone.
DMAG was shown to effectively enhance chemosensitivity of resistant cells, which makes it might be a suitable candidate for potential MDR-reversing agents.
5,5'-Dimethoxylariciresinol 4-O-glucoside Description
||The herbs of Lonicera maackii
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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