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5-Hydroxyflavone
5-Hydroxyflavone
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CAS No. 491-78-1 Price $30 / 20mg
Catalog No.CFN70123Purity>=98%
Molecular Weight238.2Type of CompoundFlavonoids
FormulaC15H10O3Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison
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    5-Hydroxyflavone

    5-Hydroxyflavone
    Product Name 5-Hydroxyflavone
    CAS No.: 491-78-1
    Catalog No.: CFN70123
    Molecular Formula: C15H10O3
    Molecular Weight: 238.2 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The stem barks of Garcinia malaccensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
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    product package
  • Antioxidants (Basel).2021, 10(1):112.
  • Phytomedicine.2018, 41:62-66
  • In Vivo.2022, 36(3):1136-1143.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: 5-Hydroxyflavone exhibits inhibition of platelet aggregation in human whole blood which induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen.
    In vitro:
    Oriental Journal of Chemistry, 2013, 29(3):871-875.
    Antiplatelet aggregation activity of Hydroxyflavane, 2’-Hydroxyflavanone, Paeonol and bergenin isolated from stem bark of Garcinia malaccensis in human whole blood.[Reference: WebLink]

    METHODS AND RESULTS:
    Four known compounds, 5-Hydroxyflavone (1), 2’-Hydroxyflavanone (2), Paeonol (3) and bergenin (4), were isolated from the methanolic extract of the stem bark of Garcinia malaccensis for the first time through combination of vacuum and radial chromatography techniques. The structures of the secondary metabolites (1-4) were elucidated on the basis of their spectroscopic evidence and comparison with the published data.
    CONCLUSIONS:
    All isolated compounds exhibited inhibition of platelet aggregation in human whole blood which induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen. 2’-Hydroxyflavanone (2) showed inhibitory effect on platelet aggregation caused by two inducers with IC50 47.8± 2.1 AA and 147.2 ± 4.1 ADP.
    5-Hydroxyflavone Description
    Source: The stem barks of Garcinia malaccensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1982 mL 20.9908 mL 41.9815 mL 83.9631 mL 104.9538 mL
    5 mM 0.8396 mL 4.1982 mL 8.3963 mL 16.7926 mL 20.9908 mL
    10 mM 0.4198 mL 2.0991 mL 4.1982 mL 8.3963 mL 10.4954 mL
    50 mM 0.084 mL 0.4198 mL 0.8396 mL 1.6793 mL 2.0991 mL
    100 mM 0.042 mL 0.2099 mL 0.4198 mL 0.8396 mL 1.0495 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    5-Hydroxyflavone References Information
    Citation [1]

    J Agric Food Chem, 2009, 57(1):83-89.

    Metabolism and Pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (Fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and Antihemolysis Effects of Fisetin and Its Serum Metabolites.[Pubmed: 19090755]
    3,3',4',7-Tetrahydroxyflavone (fisetin) has shown various beneficial bioactivities.
    METHODS AND RESULTS:
    This study investigated the metabolism and pharmacokinetics of fisetin, 5-Hydroxyflavone (5-OH-flavone), and 7-hydroxyflavone (7-OH-flavone) in male Sprague-Dawley rats. Blood was withdrawn via cardiopuncture and assayed by HPLC before and after hydrolysis with sulfatase and beta-glucuronidase. The results indicated that after intravenous administration of fisetin (10 mg/kg of bw), fisetin declined rapidly and fisetin sulfates/glucuronides emerged instantaneously. When fisetin (50 mg/kg of bw) was given orally, fisetin parent form was transiently present in serum only during the absorption phase, whereas fisetin sulfates/glucuronides predominated. The serum metabolites of fisetin showed less potent inhibition on 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH)-induced hemolysis than fisetin. Following oral administrations of 40 mg/kg of bw of 5-OH-flavone and 7-OH-flavone, the glucuronide of 5-OH-flavone and the sulfate/glucuronide of 7-OH-flavone were found in serum, whereas no traces of parent forms were detected.
    CONCLUSIONS:
    In conclusion, fisetin and 7-OH-flavone were rapidly and extensively biotransformed into their sulfate/glucuronide, whereas 5-OH-flavone was exclusively metabolized to glucuronide.
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