ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: firstname.lastname@example.org
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $175.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int Immunopharmacol. 2020, 83:106403.J Pharm Biomed Anal.2019, 172:268-277Plant Cell Physiol.2018, 59(1):128-141Food Res Int.2022, 157:111207.J Microbiol Biotechnol....2022...Pharmaceuticals (Basel)....2021...Molecules.2021, 26(6):1635. Nutrients.2018, 10(7)
Pharmaceutics.2022, 14(3):564.Molecules.2020, 25(3):734J of Applied Biological Chem....2020...Food Sci Biotechnol....2021...Phys Chem Chem Phys....2018...Int J Mol Sci.2022, 23(20):12516. J Applied Biological Chemistry...2021...Int J Biol Macromol....2020...
Molecules.2019, 24(16):E2985Korean j.of Pharm.2017, 70-76Food Science&Tech. Res....2022...Preprints2022, 2022030063.Heliyon2022, 8(2):e08866.Antiviral Res.2021, 193:105142. J Agric Food Chem.2016, 64(35):6783-90
Our products had been exported to the following research institutions and universities, And still growing.
Universidade do Porto (Portugal)Florida A&M University (USA)University of Perugia (Italy)University of Parma (Italy)
Kyoto University (Japan)University of Amsterdam (Netherlands)Funda??o Universitária de Dese... (Brazil)Florida International University (USA)
The Ohio State University (USA)Sanford Burnham Medical Researc... (USA)Subang Jaya Medical Centre (Malaysia)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0. Sci Rep.2019, 9(1):6429J Appl Microbiol.2022, 132(2):949-963.Analytical sci. & Tech2016, 186-193Phytomedicine.2021, 93:153789. Cell.2022, 185(23):4298-4316.e21. Vietnam Journal of Food Control2022, 5(3):pp.390-401.Front Cell Dev Biol.2020, 8:32.The Korea Journal of Herbology2016, 29-35BMB Rep.2020, 53(4):218-222.
Related Screening Libraries
||5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also
shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB. 5-O-Caffeoylshikimic acid can remarkably inhibit the macrophage migration and adhesion. It also shows moderate MDR reversal activity. |
||NO | TNF-α | IL Receptor | COX | PGE | NF-kB|
|In Vivo. 2009 Jul-Aug;23(4):545-50. |
|Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators.[Pubmed: 19567388]|
|Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.
MATERIALS AND METHODS:
Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation.
The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin.
Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice.|
|Evid Based Complement Alternat Med. 2014;2014:910438. |
|Antioxidant and Anti-Inflammatory Activities of Phenolic-Enriched Extracts of Smilax glabra.[Pubmed: 25477999 ]|
|Smilax glabra Roxb. has been used for a long time as both food and folk medicine. In the present study, phenolic-enriched extract of S. glabra (PEESG) was extracted with 70% ethanol and purified by HP-20 column chromatography.
METHODS AND RESULTS:
Its antioxidant and anti-inflammatory activities were evaluated by radical scavenging assay, reducing power determination, and lipopolysaccharide (LPS)-induced RAW264.7 cells assays, respectively. PEESG exhibited obviously scavenging capacity for DPPH and ABTS radicals, as well as significant reducing power for ferric ion. Particularly, PEESG (12.5-50 μg/mL) showed a significantly higher efficiency for scavenging ABTS than that of ascorbic acid and no significant difference with ascorbic acid for DPPH scavenging. PEESG also possessed a significant suppression effect on proinflammatory mediators production, such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), in LPS-induced RAW264.7 cells. In addition, the main ingredients of PEESG were identified using ultrahigh pressure liquid chromatography coupled to electrospray mass spectrometry (U-HPLC-ESI-MS).
Seventeen components, including 5-O-Caffeoylshikimic acid, neoastilbin, astilbin, neoisoastilbin, isoastilbin, engetin and isoengeletin were identified. These findings strongly suggest the potential of PEESG as a natural antioxidant and anti-inflammatory agent.
5-O-Caffeoylshikimic acid Description
||The fruits of Illicium verum.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Arch Pharm Res. 2014 Jul;37(7):947-54. |
|Secondary metabolites isolated from Castilleja rubra exert anti-inflammatory effects through NF-κB inactivation on lipopolysaccharide-induced RAW264.7 macrophages.[Pubmed: 24062082 ]|
|8-Epiloganin (1), mussaenoside (2), and 5-O-Caffeoylshikimic acid (3) have been isolated from Castilleja rubra, and the anti-inflammatory properties of these metabolites in a cell culture system were investigated.|
METHODS AND RESULTS:
Compounds 1-3 suppressed not only the production of nitric oxide (NO) and prostaglandin E2, but also the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. Compounds 1-3 also inhibited the release of pro-inflammatory cytokines induced by LPS, namely, tumor necrosis factor-α and interleukin-1β.
The underlying mechanism of the anti-inflammatory action of compounds 1-3 was associated with downregulation of nuclear factor-κB.
|J Pharm Biomed Anal. 2013 Apr 15;77:44-8. |
|Macrophage biospecific extraction and HPLC-ESI-MSn analysis for screening immunological active components in Smilacis Glabrae Rhizoma.[Pubmed: 23384550 ]|
|A cell-permeable membrane, as typified by Transwell insert Permeable Supports, permit accurate repeatable invasion assays, has been developed as a tool for screening immunological active components in Smilacis Glabrae Rhizoma (SGR).
In this research, components in the water extract of SGR (ESGR) might conjugate with the receptors or other targets on macrophages which invaded Transwell inserts, and then the eluate which contained components biospecific binding to macrophages was identified by HPLC-ESI-MS(n) analysis.
METHODS AND RESULTS:
Six compounds, which could interact with macrophages, were detected and identified. Among these compounds, taxifolin (2) and astilbin (4) were identified by comparing with the chromatography of standards, while the four others including 5-O-Caffeoylshikimic acid (1), neoastilbin (3), neoisoastilbin (5) and isoastilbin (6), were elucidated by their structure clearage characterizations of tandem mass spectrometry. Then compound 1 was isolated and purified from SGR, along with 2 and 4, was applied to the macrophage migration and adhesion assay in HUVEC (Human Umbilical Vein Endothelial Cells) -macrophages co-incultured Transwell system for immunological activity assessment. The results showed that compounds 1, 2 and 4 with concentration of 5μM (H), 500nM (M) and 50nM (L) could remarkably inhibit the macrophage migration and adhesion (Vs AGEs (Advanced Glycation End Produces) group, 1-L, 2-H and 4-L groups: p<0.05; other groups: p<0.01). Moreover, 1 and 4 showed satisfactory dose-effect relationship.
In conclusion, the application of macrophage biospecific extraction coupled with HPLC-ESI-MS(n) analysis is a rapid, simple and reliable method for screening immunological active components from Traditional Chinese Medicine.
Tags: buy 5-O-Caffeoylshikimic acid | 5-O-Caffeoylshikimic acid supplier | purchase 5-O-Caffeoylshikimic acid | 5-O-Caffeoylshikimic acid cost | 5-O-Caffeoylshikimic acid manufacturer | order 5-O-Caffeoylshikimic acid | 5-O-Caffeoylshikimic acid distributor