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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $85.2 / In-stock||Other Packaging
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More articles cited ChemFaces products.
Biomolecules.2020, 10(6):925.Life Sci.2021, 270:119074.Phytomedicine.2020, 79, 153351Vietnam Journal of Food Control....2022...Food Res Int.2022, 157:111397.Am J Chin Med.2016, 44(8):1719-1735Molecules.2022, 27(5):1675Int J Food Sci Nutr.2019, 70(7):825-833
Int J Mol Sci.2020, 21(22):8816. Front Pharmacol.2021, 12:690113.Pharmaceutics.2022, 14(3):564.J Nat Med.2017, 71(2):380-388Cancers (Basel).2023, 15(1):293.Nutrients.2018, 11(1):E17Crystals2020, 10(3), 206.J of L. Chroma.&Related Tech...2017...
ACS Chem Biol.2019, 14(5):873-881University of Guelph2021, 12.Molecular & Cellular Toxicology...2017...J Sep Sci.2018, 41(7):1682-1690Nat Prod Commun.2018, 10.1177Current Traditional Medicine, ...2021...Nutrients.2020, 12(12):3638.
Our products had been exported to the following research institutions and universities, And still growing.
Utrecht University (Netherlands)Universitas Airlangga (Indonesia)Research Unit Molecular Epigene... (Germany)Nicolaus Copernicus Uniwersity (Poland)
Griffith University (Australia)Universidade Católica Portuguesa (Portugal)Lund University (Sweden)Chinese University of Hong Kong (China)
Universite de Lille1 (France)Yale University (USA)University of Eastern Finland (Finland)
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Appl. Sci. 2021, 11(10),4666.Korean Journal of Pharmacognosy.2015, 46(4):352-364Vietnam Journal of Science2022, 64(2), 69-75.J AOAC Int.2023, 106(1):56-64.Life (Basel).2021, 11(7):616. JEJU National University2022, 10478.Phytother Res.2022, 10.1002:ptr.7626.J Nat Med.2022, 76(1):59-67. Phytother Res.2016, 30(12):2020-2026Cardiovasc Toxicol.2019, 19(4):297-305
Related Screening Libraries
||6,7,8-Trimethoxycoumarin has antiviral activity, it shows high anti-HRV-2 effect , with IC (50) value of 11.98 muM. It also can improve gastroprotective effects.|
||P450 (e.g. CYP17) | AChR | Antifection | HRV|
|Planta Med. 2009 Feb;75(3):195-204. |
|In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens.[Pubmed: 19096995]|
|The identification of targets whose interaction is likely to result in the successful treatment of a disease is of growing interest for natural product scientists. |
METHODS AND RESULTS:
In the current study we performed an exemplary application of a virtual parallel screening approach to identify potential targets for 16 secondary metabolites isolated and identified from the aerial parts of the medicinal plant RUTA GRAVEOLENS L. Low energy conformers of the isolated constituents were simultaneously screened against a set of 2208 pharmacophore models generated in-house for the IN SILICO prediction of putative biological targets, i. e., target fishing. Based on the predicted ligand-target interactions, we focused on three biological targets, namely acetylcholinesterase (AChE), the human rhinovirus (HRV) coat protein and the cannabinoid receptor type-2 (CB (2)). For a critical evaluation of the applied parallel screening approach, virtual hits and non-hits were assayed on the respective targets. For AChE the highest scoring virtual hit, arborinine, showed the best inhibitory IN VITRO activity on AChE (IC (50) 34.7 muM). Determination of the anti-HRV-2 effect revealed 6,7,8-Trimethoxycoumarin and arborinine to be the most active antiviral constituents with IC (50) values of 11.98 muM and 3.19 muM, respectively. Of these, arborinine was predicted virtually. Of all the molecules subjected to parallel screening, one virtual CB (2) ligand was obtained, i. e., rutamarin. Interestingly, in experimental studies only this compound showed a selective activity to the CB (2) receptor ( Ki of 7.4 muM) by using a radioligand displacement assay.
The applied parallel screening paradigm with constituents of R. GRAVEOLENS on three different proteins has shown promise as an IN SILICO tool for rational target fishing and pharmacological profiling of extracts and single chemical entities in natural product research.
|J Ethnopharmacol. 1999 Dec 15;68(1-3):283-8. |
|Antiviral flavonoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine.[Pubmed: 10624889]|
|The antipicornaviral activity of an ethanolic extract of the green aerial parts of the Australian plant Pterocaulon sphacelatum (Labill.) Benth. & Hook. f. ex F. Muell. has been investigated. This plant has been a favoured traditional medicine, used for the treatment of colds by the Australian Aboriginal people. |
METHODS AND RESULTS:
Antiviral activity-guided fractionation of the extract of P. sphacelatum using an inhibition of poliovirus-induced cytopathic effect assay, has yielded the antiviral flavonoid chrysosplenol C (3,7,3'-trimethoxy-5,6,4'-trihydroxyflavone). This compound is a 4'-hydroxy-3-methoxyflavone, one of a group of compounds known to be potent and specific inhibitors of picornaviral replication.
These compounds inhibit the replication of rhinoviruses, the most frequent causative agent of the common cold. The coumarin 6,7,8-Trimethoxycoumarin was also isolated from the ethanolic extract.
|Nutrients. 2015 Mar 13;7(3):1945-64. |
|Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.[Pubmed: 25781220]|
|Among these compounds, 5,6,7-trimethoxycoumarin and 6,7,8-Trimethoxycoumarin were found to have gastroprotective activity greater than the standard drug rebamipide; 6-methoxy-7,8-methylenedioxycoumarin, 6-methoxy-7,8-(1-methoxy)-methylenedioxycoumarin, 6,7-methylenedioxycoumarin, and 6,7-(1-methoxy)-methylenedioxycoumarin were found to be equipotent or less potent that of rebamipide. Pharmacological studies suggest that the presence of a methoxy group at position C-5 or C-8 of the scoparone's phenyl ring significantly improves gastroprotective activity, whereas the presence of a dioxolane ring at C-6, C-7, or C-8 was found to have decreased activity. |
METHODS AND RESULTS:
In order to assess toxicological safety, two of the potent gastroprotective scoparone derivatives-5,6,7-trimethoxycoumarin and 6,7,8-Trimethoxycoumarin-were examined for their acute toxicity in mice as well as their effect on cytochrome P450 (CYP) enzyme activity. These two compounds showed low acute oral toxicity in adult male and female mice, and caused minimal changes to CYP3A4 and CYP2C9 enzyme activity.
These results indicate that compared to other scoparone derivatives, 5,6,7-trimethoxycoumarin and 6,7,8-Trimethoxycoumarin can improve gastroprotective effects, and they have low toxicity and minimal effects on drug-metabolizing enzymes.
||The herbs of Viola yedonensis Makino.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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