7beta-Methoxyrosmanol | CAS:24703-38-6

7beta-Methoxyrosmanol

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Description:

7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.

Targets:

DGAT1

In vitro:

Food Chemistry, 2012, 132(4):1775-1780.

Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity.[Reference: WebLink]

Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes.
METHODS AND RESULTS:
Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4), 7beta-Methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8).
CONCLUSIONS:
Compounds 1–8 inhibited DGAT1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalis exhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells.

7beta-Methoxyrosmanol Description

Source:	The herbs of Rosmarinus officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	7beta-Methoxyrosmanol
Price:
CAS No.:	24703-38-6
Catalog No.:	CFN92990
Molecular Formula:	C₂₁H₂₈O₅
Molecular Weight:	360.44 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Rosmarinus officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7744 mL	13.8719 mL	27.7439 mL	55.4877 mL	69.3597 mL
5 mM	0.5549 mL	2.7744 mL	5.5488 mL	11.0975 mL	13.8719 mL
10 mM	0.2774 mL	1.3872 mL	2.7744 mL	5.5488 mL	6.936 mL
50 mM	0.0555 mL	0.2774 mL	0.5549 mL	1.1098 mL	1.3872 mL
100 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.5549 mL	0.6936 mL

CFN90366	11-Hydroxy-sugiol	88664-08-8	316.43	C₂₀H₂₈O₃
CFN92243	Salvinolone	120278-22-0	314.4	C₂₀H₂₆O₃
CFN97924	14-Deoxycoleon U	88664-09-9	330.4	C₂₀H₂₆O₄
CFN88024	6,11,12,16-Tetrahydroxy-5,8,11,13-abitetetraen-7-one	1295650-67-7	346.4	C₂₀H₂₆O₅
CFN92175	20-Deoxocarnosol	94529-97-2	316.4	C₂₀H₂₈O₃
CFN95428	2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene	1608462-12-9	332.4	C₂₀H₂₈O₄
CFN99695	6-Epidemethylesquirolin D	165074-00-0	348.4	C₂₀H₂₈O₅
CFN99956	Carnosol	5957-80-2	330.42	C₂₀H₂₆O₄
CFN93009	Isorosmanol	93780-80-4	346.42	C₂₀H₂₆O₅
CFN93024	Rosmanol	80225-53-2	344.45	C₂₀H₂₆O₅