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    Natural Products
    8'-Epicleomiscosin A
    8'-Epicleomiscosin A
    Information
    CAS No. N/A Price
    Catalog No.CFN90101Purity>=98%
    Molecular Weight386.36Type of CompoundCoumarins
    FormulaC20H18O8Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    8'-Epicleomiscosin A

    8'-Epicleomiscosin A
    Product Name 8'-Epicleomiscosin A
    CAS No.: N/A
    Catalog No.: CFN90101
    Molecular Formula: C20H18O8
    Molecular Weight: 386.36 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Source: The herbs of Buxus sinica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: 8'-Epicleomiscosin A shows strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.
    8'-Epicleomiscosin A Description
    Source: The herbs of Buxus sinica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5883 mL 12.9413 mL 25.8826 mL 51.7652 mL 64.7065 mL
    5 mM 0.5177 mL 2.5883 mL 5.1765 mL 10.353 mL 12.9413 mL
    10 mM 0.2588 mL 1.2941 mL 2.5883 mL 5.1765 mL 6.4706 mL
    50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.0353 mL 1.2941 mL
    100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5177 mL 0.6471 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Chemical & Pharmaceutical Bulletin [2004, 52(12):1458-1461]
    Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.[Reference: WebLink]

    METHODS AND RESULTS:
    A new coumarinolignoid 8'-Epicleomiscosin A (1) together with the new glycoside 8-O-beta-D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also investigated.
    CONCLUSIONS:
    The compounds exhibited potent to mild inhibition activity against the enzyme. Especially, 8'-Epicleomiscosin A showed strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.
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