ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J. of Med. Plant Research.2013, 90-151Molecules.2015, 20(10):19172-88Sci Rep.2015, 5:13194BMC Complement Altern Med.2016, 16:213J Ethnopharmacol.2016, 192:370-381Biomed Chromatogr.2016, 30(10):1573-81J Agric Food Chem.2016, 64(35):6783-90Front Pharmacol.2016, 7:460
Phytochemistry.2017, 141:162-170BMC Complement Altern Med....2017...J Ethnopharmacol.2018, 210:88-94South African J of Plant&Soil...2018...Korean J Environ Agric....2018...Front Aging Neurosci.2019, 11:230Br J Pharmacol.2020, 10.1111Food Chem.2020, 313:126079
Plant Growth Regulation...2020...Metabolites.2020, 10(12):497.Front Pharmacol.2020, 11:683.Pharmaceutics.2020, 12(9):882. Molecules.2020, 25(9):2081.Molecules.2020, 25(9):2111.Biochem Biophys Res Commun....2020...
Our products had been exported to the following research institutions and universities, And still growing.
Sapienza University of Rome (Italy)University of Auckland (New Zealand)University of East Anglia (United Kingdom)University of Bonn (Germany)
University of Wisconsin-Madison (USA)University of Queensland (Australia)University of Helsinki (Finland)University of Hertfordshire (United Kingdom)
Universidad Veracuzana (Mexico)University of the Basque Country (Spain)Funda??o Universitária de Dese... (Brazil)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Int Immunopharmacol.2020, 90:107268.Pharmacol Res.2020, 161:105205.J Korean Soc Food Sci Nutr2020, doi: 10.3746.Advances in Traditional Medicine2020, 10.1007Phytomedicine.2018, 41:62-66Nutrients.2018, 10(12):E1998Food Chem.2018, 252:207-214Ind Crops Prod.2014, 62:173-178J Ethnopharmacol.2019, 236:31-41J of Ana. Chem.2019, 74(11):1113-1121
Related Screening Libraries
|| 8'-Epicleomiscosin A shows strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.|
8'-Epicleomiscosin A Description
||The herbs of Buxus sinica
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chemical & Pharmaceutical Bulletin [2004, 52(12):1458-1461] |
|Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.[Reference: WebLink]|
METHODS AND RESULTS:
A new coumarinolignoid 8'-Epicleomiscosin A (1) together with the new glycoside 8-O-beta-D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also investigated.
The compounds exhibited potent to mild inhibition activity against the enzyme. Especially, 8'-Epicleomiscosin A showed strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.