ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
(+/-)-Anabasine
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / $13.9 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
FEBS Lett.2015, 589(1):182-7Int J Mol Sci.2021, 22(21):11836.Malaysian Journal of Analytical S...2022...Preprints2022, 202211.0388.v1.Cell Rep.2020, 32(11):108158.Appl Biochem Biotechnol....2020...Oxid Med Cell Longev....2020...Phytomedicine.2018, 40:37-47
Pharmacogn Mag.2015, 11:S585-91Lab Chip.2018, 18(6):971-978Biochemistry.2018, 57(40):5886-5896Analytical Methods2018, 10(27)British Jou. Med.&Med. Research...2014...Food and Fermentation Industries...2019...Toxicol Appl Pharmacol....2022...Antioxidants (Basel)....2021...
Int J Mol Sci.2021, 22(11):5503.Pharmaceutics.2022, 14(5):945.Int J Mol Sci.2021, 22(9):5012.J Ethnopharmacol.2017, 197:157-164Pharmacia2022, 69(3): 883-890.Life Sci.2021, 270:119074.Antioxidants (Basel).2021, 10(1):112.
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Our products had been exported to the following research institutions and universities, And still growing.
Charles University in Prague (Czech Republic)Chang Gung University (Taiwan)Julius Kühn-Institut (Germany)Centrum Menselijke Erfelijkheid (Belgium)
Washington State University (USA)Utah State University (USA)Shanghai Institute of Biochemis... (China)Chulalongkorn University (Thailand)
St. Jude Children Research Hosp... (USA)Subang Jaya Medical Centre (Malaysia)Mahidol University (Thailand)
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(+/-)-Anabasine
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manager@chemfaces.com
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service@chemfaces.com
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Fax:
+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Toxins (Basel).2021, 13(12):898.Sci Rep.2018, 8(1):12970Arch Biochem Biophys.2020, 687:108384.J of L. Chroma.&Related Tech2017, 252-258Molecules.2019, 24(16):E2985Scientific World Journal.2014, 2014:654193Pharmaceuticals (Basel).2021, 14(3):260.Research on Crops.2017, 18(3):569Ind Crops Prod.2014, 62:173-178J Agric Food Chem.2021, 69(14):4210-4222.
Related Screening Libraries
Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
Description: |
(+/-)-Anabasine and (−)-cytisine exhibit partial agonist on nicotinic acetylcholine receptor (nAChR). |
Targets: |
nAChR |
(+/-)-Anabasine Description
Source: |
The leaves of tobacco |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
6.1652 mL |
30.8261 mL |
61.6523 mL |
123.3046 mL |
154.1307 mL |
5 mM |
1.233 mL |
6.1652 mL |
12.3305 mL |
24.6609 mL |
30.8261 mL |
10 mM |
0.6165 mL |
3.0826 mL |
6.1652 mL |
12.3305 mL |
15.4131 mL |
50 mM |
0.1233 mL |
0.6165 mL |
1.233 mL |
2.4661 mL |
3.0826 mL |
100 mM |
0.0617 mL |
0.3083 mL |
0.6165 mL |
1.233 mL |
1.5413 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Animal Research: |
Brain Research, 1994,643(1-2):1-9. | Clozapine attenuates the discriminative stimulus properties of (−)-nicotine.[Reference: WebLink] | METHODS AND RESULTS: Rats were trained to discriminate 1.9 μmol/kg (−)-nicotine (0.3 mg/kg) from saline in a standard two-bar operant conditioning paradigm with food reinforcement. The effect of neuronal nicotinic acetylcholine receptor (nAChR) agonists and antagonists were verified, and the participation of dopaminergic receptors subtypes in the expression of the (−)-nicotine cue was investigated with cis-flupentixol (D1-D2 antagonist), haloperidol (D2 antagonist) and clozapine (D4 antagonist). The stereoselectivity of the behavioral response was indicated by the 10-fold less sensitivity to (+)-nicotine in (−)-nicotine-trained rats. (+/-)-Anabasine and (−)-cytisine exhibited partial agonist profiles at the 1.9 μmol/kg dose while (−)-lobeline was devoid of any effect in doses up to 19 μmol/kg. (−)-Lobeline did not show antagonist properties in this paradigm. The nicotinic channel blockers mecamylamine, chlorisondamine and hexamethonium were inactive on their own but mecamylamine and chlorisondamine were able to block the effect of (−)-nicotine. Clozapine attenuated the (−)-nicotine cue while cis-flupentixol and haloperidol were ineffective. Similar doses of cis-flupentixol significantly blocked the locomotr stimulant effect of (−)-nicotine in rats indicating that blockade of dopaminergic receptors was achieved at the doses used in the drug discrimination studies.
CONCLUSIONS:
These data suggest that the discriminative stimulus properties of (−)-nicotine are mediated through neuronal nAChRs and involves the activation of dopaminergic receptors of the D4 subtype. |
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