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(+/-)-Anabasine
(+/-)-Anabasine
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CAS No. 13078-04-1 Price $100 / 20mg
Catalog No.CFN70055Purity>=98%
Molecular Weight162.2Type of CompoundAlkaloids
FormulaC10H14N2Physical DescriptionOil
Download COA    MSDSSimilar structuralComparison
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Size /Price /Stock 10 mM * 1 mL in DMSO / $13.9 / In-stock
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    (+/-)-Anabasine

    (+/-)-Anabasine
    Product Name (+/-)-Anabasine
    CAS No.: 13078-04-1
    Catalog No.: CFN70055
    Molecular Formula: C10H14N2
    Molecular Weight: 162.2 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Oil
    Targets: nAChR
    Source: The leaves of tobacco
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $100 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
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    product package
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: (+/-)-Anabasine and (−)-cytisine exhibit partial agonist on nicotinic acetylcholine receptor (nAChR).
    Targets: nAChR
    (+/-)-Anabasine Description
    Source: The leaves of tobacco
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.1652 mL 30.8261 mL 61.6523 mL 123.3046 mL 154.1307 mL
    5 mM 1.233 mL 6.1652 mL 12.3305 mL 24.6609 mL 30.8261 mL
    10 mM 0.6165 mL 3.0826 mL 6.1652 mL 12.3305 mL 15.4131 mL
    50 mM 0.1233 mL 0.6165 mL 1.233 mL 2.4661 mL 3.0826 mL
    100 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.233 mL 1.5413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Brain Research, 1994,643(1-2):1-9.
    Clozapine attenuates the discriminative stimulus properties of (−)-nicotine.[Reference: WebLink]

    METHODS AND RESULTS:
    Rats were trained to discriminate 1.9 μmol/kg (−)-nicotine (0.3 mg/kg) from saline in a standard two-bar operant conditioning paradigm with food reinforcement. The effect of neuronal nicotinic acetylcholine receptor (nAChR) agonists and antagonists were verified, and the participation of dopaminergic receptors subtypes in the expression of the (−)-nicotine cue was investigated with cis-flupentixol (D1-D2 antagonist), haloperidol (D2 antagonist) and clozapine (D4 antagonist). The stereoselectivity of the behavioral response was indicated by the 10-fold less sensitivity to (+)-nicotine in (−)-nicotine-trained rats. (+/-)-Anabasine and (−)-cytisine exhibited partial agonist profiles at the 1.9 μmol/kg dose while (−)-lobeline was devoid of any effect in doses up to 19 μmol/kg. (−)-Lobeline did not show antagonist properties in this paradigm. The nicotinic channel blockers mecamylamine, chlorisondamine and hexamethonium were inactive on their own but mecamylamine and chlorisondamine were able to block the effect of (−)-nicotine. Clozapine attenuated the (−)-nicotine cue while cis-flupentixol and haloperidol were ineffective. Similar doses of cis-flupentixol significantly blocked the locomotr stimulant effect of (−)-nicotine in rats indicating that blockade of dopaminergic receptors was achieved at the doses used in the drug discrimination studies.
    CONCLUSIONS:
    These data suggest that the discriminative stimulus properties of (−)-nicotine are mediated through neuronal nAChRs and involves the activation of dopaminergic receptors of the D4 subtype.
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