ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $121.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Nat Prod Sci.2014, 20(3):182-190Evid Based Complement Alternat Me...2016...Sci Rep. 2017, 17332(7)Invest New Drugs.2017, 35(2):166-179J Agric Food Chem....2017...Nat Chem Biol.2018, 14(8):760-763Molecules.2019, 24(10):E1926Molecules.2019, 24(17):E3127
Molecules.2019, 24(19):E3417Molecules.2019, 24(4):E709Chin J Appl. Physiol....2019...Korean Journal of Pharmacognosy....2019...Chemistry of Natural Compounds...2019...Pharmacol Rep.2019, 71(2):289-298Sci Rep.2019, 9:19059J of Applied Pharmaceutical Scien...2020...
Plos One.2020, 10.1371Food Chem Toxicol.2020, 135:110863Food Analytical Methods...2020...Anesth Pain Med (Seoul)....2020...Molecules.2020, 25(15):3353.The Journal of Animal & Plant Sci...2020...J Ethnopharmacol.2021, 267:113615.
Our products had been exported to the following research institutions and universities, And still growing.
Rio de Janeiro State University (Brazil)University of Bonn (Germany)Donald Danforth Plant Science C... (USA)Stanford University (USA)
The Ohio State University (USA)University of Toulouse (France)University of Liège (Belgium)Universiti Sains Malaysia (Malaysia)
The University of Newcastle (Australia)University of Stirling (United Kingdom)Guangzhou Institutes of Biomedi... (China)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Antioxidants (Basel).2020, 9(2): E119FASEB J.2019, 33(2):2026-2036Oncotarget.2017, 9(3):4161-4172Sci Rep.2019, 9(1):6429Current Pharmaceutical Analysis2017, 13(5)The Japan Society for Analytical Chemistry2018, 67(4):201-206J of the Korean Society of Cosmetics and Cosmetology2018, 399-406Biofactors.2018, 44(2):168-179Evid Based Complement Alternat Med.2017, 2017:9764843Metabolites.2019, 9(11):E271
Related Screening Libraries
|| Bayogenin, arjunolic acid, hederagonic acid and 4-epi-hederagonic acid are gly-cogen phosphorylase inhibitors with moderate potency.|
||The tubers of Bolbostemma paniculatum
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|《Chinese Journal of Natural Medicines》 2010-06 |
|Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4-Epi-hederagonic Acid as Glycogen Phosphorylase Inhibitors[Reference: WebLink]|
| To study glycogen phosphorylase inhibitory activity of natural pentacyclic triterpenes bearing 23-hydroxy or 24-hydroxy. |
METHODS AND RESULTS:
Arjunolic acid, Bayogenin, hederagonic acid and 4-epi-hederagonic acid were synthesized from oleanolic acid as the starting material and biologically evaluated as glycogen phosphorylase inhibitors. Arjunolic acid, Bayogenin, hederagonic acid and 4-epi-hederagonic acid were successfully semi-synthesized by multiple steps. The synthesis of arjunolic acid was via 11 steps in about 10% overall yield, and Bayogenin via 14 steps in about 12% overall yield. Biological evaluation indicated that arjunolic acid, Bayogenin, hederagonic acid and 4-epi-hederagonic acid showed moderate potency of glycogen phosphorylase inhibition with IC50 of 53-103 μmol/L.
Arjunolic acid, Bayogenin, hederagonic acid and 4-epi-hederagonic acid are gly-cogen phosphorylase inhibitors with moderate potency. Insert of 23-hydroxy or 24-hydroxy to oleanane skeleton has a tendency to be unfavorable to GP inhibition.