Cimiracemoside C | CAS:256925-92-5 | Manufacturer ChemFaces

Cimiracemoside C

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Size /Price /Stock	10 mM * 1 mL in DMSO / $180.1 / In-stock
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Description:

The Cimicifuga racemosa extract Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and cimiracemoside C) can reduce significantly body weight, plasma glucose, improve glucose metabolism and insulin sensitivity in diabetic ob/ob mice; suggests that part of the effects may be related to AMPK activation.Ze 450 may have utility in the treatment of type 2 diabetes.

Targets:

AMPK

In vitro:

Phytomedicine. 2014 Sep 25;21(11):1382-9.

Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.[Pubmed: 25022210]

It was the aim of the present experiments to examine potential antidiabetic effects of the Cimicifuga racemosa extract Ze 450.
METHODS AND RESULTS:
Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and Cimiracemoside C) were investigated in vitro for their effects on AMP-activated protein kinase (AMPK) compared to metformin in HepaRG cells. Ze 450 (given orally (PO) and intraperitonally (IP)), metformin (PO) and controls were given over 7 days to 68 male ob/ob mice. Glucose and insulin concentrations were measured at baseline and during an oral glucose tolerance test (OGTT). Ze 450 and its components activated AMPK to the same extent as metformin. In mice, Ze 450 (PO/IP) decreased significantly average daily and cumulative weight gain, average daily food and water intake, while metformin had no effect. In contrast to metformin, PO Ze 450 virtually did not change maximum glucose levels during OGTT, however, prolonged elimination. Ze 450 administered PO and IP decreased significantly post-stimulated insulin, whereas metformin did not. HOMA-IR index of insulin resistance improved significantly after IP and PO Ze 450 and slightly after metformin. In summary, the results demonstrate that Ze 450 reduced significantly body weight, plasma glucose, improved glucose metabolism and insulin sensitivity in diabetic ob/ob mice. In vitro experiments suggest that part of the effects may be related to AMPK activation.
CONCLUSIONS:
Ze 450 may have utility in the treatment of type 2 diabetes. However, longer term studies in additional animal models or patients with disturbed glucose tolerance or diabetes may be of use to investigate this further.

Cimiracemoside C Description

Source:	The roots of Cimicifuga foetida L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Agric Food Chem. 2006 May 3;54(9):3242-53.

Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry.[Pubmed: 16637680]

Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States.
METHODS AND RESULTS:
In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography-photodiode array detection and a new selected ion monitoring liquid chromatography-mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not Cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species.
CONCLUSIONS:
For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected.

Product Name	Cimiracemoside C
Price:	$248 / 10mg
CAS No.:	256925-92-5
Catalog No.:	CFN98288
Molecular Formula:	C₃₅H₅₆O₉
Molecular Weight:	620.8 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Cimicifuga foetida L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihyperglycemic Compound Library Insulin-stimulated action Compound Library Triterpenoids Compound Library AMPK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6108 mL	8.0541 mL	16.1082 mL	32.2165 mL	40.2706 mL
5 mM	0.3222 mL	1.6108 mL	3.2216 mL	6.4433 mL	8.0541 mL
10 mM	0.1611 mL	0.8054 mL	1.6108 mL	3.2216 mL	4.0271 mL
50 mM	0.0322 mL	0.1611 mL	0.3222 mL	0.6443 mL	0.8054 mL
100 mM	0.0161 mL	0.0805 mL	0.1611 mL	0.3222 mL	0.4027 mL

CFN98288	Cimiracemoside C	256925-92-5	620.8	C₃₅H₅₆O₉
CFN99637	Cimiside B	152685-91-1	752.9	C₄₀H₆₄O₁₃
CFN90649	Cimiracemoside D	290821-39-5	678.39	C₃₇H₅₈O₁₁
CFN70310	Cimiaceroside A	210643-83-7	618.8	C₃₅H₅₄O₉
CFN70324	Cimiracemoside F	264875-61-8	676.9	C₃₇H₅₆O₁₁
CFN90682	Acetylcimigenol 3-O-alpha-L-arabinopyranside	402513-88-6	662.9	C₃₇H₅₈O₁₀
CFN92380	25-O-methylcimigenol-3-O-beta-D-xylopyranoside	27994-13-4	634.9	C₃₆H₅₈O₉
CFN92379	25-O-ethylcimigenol-3-O-beta-D-xylopyranoside	914086-57-0	648.9	C₃₇H₆₀O₉
CFN95628	24-epi-24-O-acetyl-7,8-didehydrohydroshengmanol-3-O-beta-D-xylopyranoside	228251-25-0	678.9	C₃₇H₅₈O₁₁
CFN92381	7,8-Didehydrocimigenol	150972-72-8	486.7	C₃₀H₄₆O₅