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    Natural Products
    Confluentin
    Confluentin
    Information
    CAS No. 585534-03-8 Price
    Catalog No.CFN98991Purity>=98%
    Molecular Weight326.5 Type of CompoundPhenols
    FormulaC22H30O2Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Confluentin

    Confluentin
    Product Name Confluentin
    CAS No.: 585534-03-8
    Catalog No.: CFN98991
    Molecular Formula: C22H30O2
    Molecular Weight: 326.5 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: Histamine Receptor | Antifection
    Source: The herbs of Rhododendron spinuliferum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • J Nat Med.2020, 74(3):550-560.
  • Front Pharmacol.2020, 11:251.
  • J. of The Korean Society of Food Culture2017, 144-149
  • Internoational J of Toxicology2020, 10.1177.
  • J Ethnopharmacol.2017, 206:327-336
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Functional Ecology2020, doi: 10.1111.
  • China Pharmacy2015, 26(27)
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Sci Rep. 2018, 462(8)
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antibacterial Compound Library
  • Cytotoxic Compound Library
  • Anti-histamine release Compound Library
  • Phenols Compound Library
  • Histamine Receptor Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro.
    Targets: Histamine Receptor | Antifection
    In vitro:
    J Nat Prod. 2013 Jan 25;76(1):79-84.
    Meroterpenoid pigments from the basidiomycete Albatrellus ovinus.[Pubmed: 23305465]

    METHODS AND RESULTS:
    Eight grifolin derivatives, involving three new monomers, albatrelins A-C (1-3), three novel dimers (meroterpenoid pigments), albatrelins D-F (4-6), and two known ones, 6a,7,8,9,10,10a-hexahydro-3,6,9-trimethyl-6-(4-methyl-3-penten-1-yl)-1,9-epoxy-6H-dibenzo[b,d]pyran (7) and Confluentin (8), were isolated from Albatrellus ovinus. Their structures were established by extensive spectroscopic analysis. The absolute configurations of compounds 2-4 were determined as 9R by comparing their optical rotations with data reported in the literature.
    CONCLUSIONS:
    Albatrelin F (6) was isolated as a pair of C-2' tautomers with a ratio of 1.3:1. Confluentin (8) showed weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro.
    Arch Pharm (Weinheim). 2003 Apr;336(2):119-26.
    Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin.[Pubmed: 12761765]
    Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), Confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation.
    METHODS AND RESULTS:
    The isolation of these compounds from A. confluens and structure elucidation of the novel natural product Confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured.
    CONCLUSIONS:
    In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the microM range), rather than exhibiting agonistic activities.
    Planta Med. 2010 Feb;76(2):182-5.
    Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis.[Pubmed: 19644795]

    METHODS AND RESULTS:
    Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24( Z)-diene-26-oic acid (1) from J. hirtus and Confluentin (2), grifolin (3), and neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1- 4 demonstrated MIC values of 40, 20, 10, and 20 microg/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 microg/mL, respectively, against E. faecalis.
    CONCLUSIONS:
    Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.
    Confluentin Description
    Source: The herbs of Rhododendron spinuliferum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0628 mL 15.3139 mL 30.6279 mL 61.2557 mL 76.5697 mL
    5 mM 0.6126 mL 3.0628 mL 6.1256 mL 12.2511 mL 15.3139 mL
    10 mM 0.3063 mL 1.5314 mL 3.0628 mL 6.1256 mL 7.657 mL
    50 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.2251 mL 1.5314 mL
    100 mM 0.0306 mL 0.1531 mL 0.3063 mL 0.6126 mL 0.7657 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2004 Jul;67(7):1106-9.
    Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum.[Pubmed: 15270561]

    METHODS AND RESULTS:
    Four new prenylated orcinol derivatives, daurichromenes A-D (1-4), along with three known compounds, Confluentin (5), grifolin (6), and orcinol (7), have been isolated from the Chinese medicinal plant Rhododendron dauricum. Their structures were established as 2R-(7'-hydroxy-4',8'-dimethyl-3'E,8'-nonadienyl)-5-hydroxy-2,7-dimethyl-2H-chromene (1), 2R-(3'-hydroxy-8'-methyl-4'-methyliden-7'-nonaenyl)-5-hydroxy-2,7-dimethyl-2H-chromene (2), 2R-(8'-hydroxy-4',8'-dimethyl-3'E,6'Z-nonadienyl)-5-hydroxy-2,7-dimethyl-2H-chromene (3), and 2R-(9'-hydroxy-4',8'-dimethyl-3'E,7'E-nonadienyl)-5-hydroxy-2,7-dimethyl-2H-chromene (4) by analysis of spectral data.
    CONCLUSIONS:
    The absolute configuration of the asymmetric carbons at the chromene ring in 1-5 was determined as R from their circular dichroism spectra. Compounds 1-6 significantly inhibited compound 48/80-induced histamine release from rat peritoneal mast cells.
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