Science | Nature | Cell | View More
Natural Products
Debilon
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Debilon
Price: $398 / 5 mg
CAS No.: 26808-51-5
Catalog No.: CFN89419
Molecular Formula: C15H22O2
Molecular Weight: 234.33 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The roots of Nardostachys chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $278.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Michigan State University (USA)
  • Charles Sturt University (Denmark)
  • National Hellenic Research Foun... (Greece)
  • Mahatma Gandhi University (India)
  • Florida A&M University (USA)
  • Instituto de Investigaciones Ag... (Chile)
  • Melbourne University (Australia)
  • Monash University (Australia)
  • Tohoku University (Japan)
  • Aarhus University (Denmark)
  • University of British Columbia (Canada)
  • More...
Package
Featured Products
Picrasidine I

Catalog No: CFN99019
CAS No: 100234-59-1
Price: $368/5mg
Quercetin 3-O-malonylglucoside

Catalog No: CFN91762
CAS No: 96862-01-0
Price: $238/5mg
Tussilagone

Catalog No: CFN90629
CAS No: 104012-37-5
Price: $148/20mg
Europine

Catalog No: CFN00264
CAS No: 570-19-4
Price: $ /
Oleocanthal

Catalog No: CFN70331
CAS No: 289030-99-5
Price: $ / mg
Pinocembrin

Catalog No: CFN98740
CAS No: 480-39-7
Price: $40/20mg
Ginsenoside F4

Catalog No: CFN90757
CAS No: 181225-33-2
Price: $/mg
2-Hydroxynaringenin

Catalog No: CFN97950
CAS No: 58124-18-8
Price: $ / mg
(+)-Epipinoresinol

Catalog No: CFN92288
CAS No: 24404-50-0
Price: $338/5mg
4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Debilon shows cytotoxic activity against P-388 cells.
Targets: NO
In vitro:
Bioorg Med Chem Lett. 2012 Jan 1;22(1):706-8.
Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.[Pubmed: 22079762 ]

METHODS AND RESULTS:
The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), Debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR.
CONCLUSIONS:
Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC(50) values of 4.6-21.6 μM.
Debilon Description
Source: The roots of Nardostachys chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
11alpha-hydroxy-3,7-dioxo-5alpha-l...

Catalog No: CFN95592
CAS No: 1245703-70-1
Price: $413/5mg
1-Phenyl-2-propanol

Catalog No: CFN95129
CAS No: 14898-87-4
Price: $30/20mg
Glicoricone

Catalog No: CFN95063
CAS No: 161099-37-2
Price: $318/5mg
[(1(10)E,2R,4R)]-2-Methoxy-8,12-ep...

Catalog No: CFN95198
CAS No: 75412-95-2
Price: $318/10mg
Isovalerylshikonin

Catalog No: CFN95222
CAS No: 52387-14-1
Price: $318/10mg
Isonemerosin

Catalog No: CFN95008
CAS No: 181524-79-8
Price: $268/20mg
Carasinol B

Catalog No: CFN95042
CAS No: 777857-86-0
Price: $333/5mg
Carasinol D

Catalog No: CFN95044
CAS No: 1072797-66-0
Price: $333/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.2675 mL 21.3374 mL 42.6749 mL 85.3497 mL 106.6872 mL
5 mM 0.8535 mL 4.2675 mL 8.535 mL 17.0699 mL 21.3374 mL
10 mM 0.4267 mL 2.1337 mL 4.2675 mL 8.535 mL 10.6687 mL
50 mM 0.0853 mL 0.4267 mL 0.8535 mL 1.707 mL 2.1337 mL
100 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8535 mL 1.0669 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4.
Cytotoxic sesquiterpenes from Nardostachys chinensis.[Pubmed: 8370115]

METHODS AND RESULTS:
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), Debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method.
CONCLUSIONS:
All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.
Picrasidine I

Catalog No: CFN99019
CAS No: 100234-59-1
Price: $368/5mg
Quercetin 3-O-malonylglucoside

Catalog No: CFN91762
CAS No: 96862-01-0
Price: $238/5mg
Tussilagone

Catalog No: CFN90629
CAS No: 104012-37-5
Price: $148/20mg
Europine

Catalog No: CFN00264
CAS No: 570-19-4
Price: $ /
Oleocanthal

Catalog No: CFN70331
CAS No: 289030-99-5
Price: $ / mg
Pinocembrin

Catalog No: CFN98740
CAS No: 480-39-7
Price: $40/20mg
Ginsenoside F4

Catalog No: CFN90757
CAS No: 181225-33-2
Price: $/mg
2-Hydroxynaringenin

Catalog No: CFN97950
CAS No: 58124-18-8
Price: $ / mg
(+)-Epipinoresinol

Catalog No: CFN92288
CAS No: 24404-50-0
Price: $338/5mg
4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg
Tags: buy Debilon | Debilon supplier | purchase Debilon | Debilon cost | Debilon manufacturer | order Debilon | Debilon distributor