Science | Nature | Cell | View More
Natural Products
Spathulenol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Spathulenol
Price:
CAS No.: 6750-60-3
Catalog No.: CFN97150
Molecular Formula: C15H24O
Molecular Weight: 220.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The herbs of Salvia sclarea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Liège (Belgium)
  • Donald Danforth Plant Science C... (USA)
  • Seoul National University (Korea)
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • Florida International University (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • Almansora University (Egypt)
  • Auburn University (USA)
  • Mendel University in Brno (Czech Republic)
  • Charles Sturt University (Denmark)
  • Ateneo de Manila University (Philippines)
  • More...
Package
Featured Products
Glycyrin

Catalog No: CFN89404
CAS No: 66056-18-6
Price: $368/5mg
Cyclocurcumin

Catalog No: CFN95103
CAS No: 153127-42-5
Price: $338/10mg
Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg
Scoparone

Catalog No: CFN99314
CAS No: 120-08-1
Price: $30/20mg
Lithospermic acid

Catalog No: CFN98546
CAS No: 28831-65-4
Price: $138/20mg
Eupatilin

Catalog No: CFN90190
CAS No: 22368-21-4
Price: $68/20mg
Pinocembrin chalcone

Catalog No: CFN96919
CAS No: 4197-97-1
Price: $/mg
Skullcapflavone II

Catalog No: CFN92216
CAS No: 55084-08-7
Price: $218/10mg
Picrasidine I

Catalog No: CFN99019
CAS No: 100234-59-1
Price: $368/5mg
Dehydroandrographolide

Catalog No: CFN99770
CAS No: 134418-28-3
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway; it presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer.
Targets: P-gp | Caspase
In vitro:
Phytother Res. 2011 Apr;25(4):557-62.
Identification of spathulenol in Salvia mirzayanii and the immunomodulatory effects.[Pubmed: 20857430]
The methanol extract of Salvia mirzayanii has shown an immunomodulatory effect on peripheral blood lymphocytes.
METHODS AND RESULTS:
Bioassay-guided fractionation using a lymphocyte proliferation assay on Salvia mirzayanii was performed in order to purify and identify the active compounds. Fractionation of the methanol extract and purification of the components using normal column chromatography and preparative thin layer chromatography resulted in identification of the bioactive compound, Spathulenol, with an immunoinhibitory effect. Identification of this compound was performed by 1D and 2D NMR methods and HRMS. Treatment of activated lymphocytes with a concentrated fraction containing 62% of Spathulenol (SP) showed a decrease in the proliferation of lymphocytes with an IC(50) of 85.4 ± 11.08 µg/mL. Flow cytometry analysis using annexin V and propidium iodide staining of the stimulated peripheral blood lymphocytes in the presence of Spathulenol demonstrated a dose dependent increase in the percentage of apoptotic cells (IC(50) ; 77.2 ± 5.31 µg/mL). No significant increase in caspase 3 activity in a 20 h treatment of stimulated lymphocytes compared with the control was observed.
CONCLUSIONS:
In conclusion, this study identified the possible activity of Spathulenol as one of the immunomodulatory compounds present in Salvia mirzayanii. Spathulenol showed the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway.
J Ethnopharmacol . 2018 Jan 10;210:351-358.
Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol[Pubmed: 28844678]
Abstract Ethnopharmacological relevance: Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence demonstrating this activity. Aim of the study: To evaluate the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of P. guineense and Spathulenol (a major constituent). The study was conducted in part to provide evidence supporting the ethnobotanical use of the leaves of this species. Material and methods: The essential oil (EOPG) was extracted from the leaves of P. guineense by hydrodistillation and analysed by gas chromatography-mass spectrometry (GC-MS). The major compound, Spathulenol (PG-1), was isolated in a chromatographic column and characterized by nuclear magnetic resonance (NMR). EOPG and PG-1 were evaluated in vitro for antioxidant activity by DPPH, ABTS and MDA methods; anti-inflammatory potential was assessed using two models, including pleurisy and oedema, in mice. The impact of EOPG and PG-1 on cell proliferation was determined via spectrophotometric quantification of the cellular protein content using a sulforhodamine B assay, and anti-Mycobacterium tuberculosis activity was determined using the REMA method. Results: A total of 38 components were identified from the EOPG, with the sesquiterpenic alcohol Spathulenol (PG-1) (80.7%) being the major constituent. EOPG and PG-1 exhibited the highest antioxidant activities in the DPPH and MDA system compared with reference standard, with IC50 values ranging from 26.13 to 85.60μg/mL. Oral administration of EOPG and PG-1 showed significant inhibition in the Cg-induced mice paw oedema and pleurisy model. The EOPG (GI50 = 0.89μg/mL) and PG-1 (GI50 = 49.30μg/mL) were particularly effective against the ovarian cancer cell line. Both showed moderate antimycobacterial activity. Conclusion: For the first time, this study demonstrated the antioxidant, anti-inflammatory, antiproliferative and antimycobacterial properties of the essential oil of P. guineense (leaves were collected in Dourados-MS) and Spathulenol, collaborating the etnhopharmacologycal use of this plant due to its an anti-inflammatory effect. Keywords: (1)H NMRProton nuclear magnetic resonance of hydrogen; (13)C NMRCarbon-13 nuclear magnetic resonance; 786-0Renal; AA%Antioxidant activity; ABTS2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid); Anti-Mycobacterium tuberculosis; Antioxidant; Antiproliferative; Araçá; BHTButylated hydroxytoluene; CCColumn chromatography; CDCl(3)Deuterated chloroform; CO(2)Carbon dioxide; Cgλ–carrageenan; DEXADexamethasone; DMSODimethylsulfoxide; DOXDoxorubicin; DPPH2,2-Diphenyl-1-picrylhydrazyl; EOPG-1Essential oil of P. guineense-sub-fraction 1; EOPG-4Essential oil of P. guineense-sub-fraction 4; EOPG-7Essential oil of P. guineense-sub-fraction 7; EOPGEssential oil of Psidium guineense; GC-MSGas chromatograph - mass spectrometry; GI(50)Growth inhibitory for 50% of cell; HT-29Colon cell line; HaCaTKeratinocytes; I%Inhibition percentage; IC(50)Concentration resulting in 50% inhibition; IL-1βInterleukin-1 beta; IL-6Interleukin-6; IL-8Interleukin-8; IPPIsopentenyl pyrophosphate; K-562Leukaemia; LC(50)Concentration killing 50% of cells; MCF-7Breast; MDAMalondialdehyde; MHzMegahertz; MICConcentration inhibition minimum; MM-1Matriz metalloproteinase-1; MTBMycobacterium tuberculosis; NCI-ADR/RESOvarian expressing the phenotype of multiple drug resistance; NCI-H460Lung; NCINational cancer institute; NONitric oxide; OVCAR-3Ovarian; Oedema; PBSPhosphate buffered saline; PCO-3Prostate; PG-1Compound Spathulenol; Pleurisy; REMAResazurin microtiter assay; RPMI-1640Roswell park memorial institute 1640 medium; TGIGrowth inhibitory for 50% of cell; TLCThin-layer chromatography; TMSTetramethylsilane; TNF-αTumour necrosis factors-alpha; U251Glioma.
Spathulenol Description
Source: The herbs of Salvia sclarea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Quercetin 3-O-beta-D-glucosyl-(1->...

Catalog No: CFN95277
CAS No: 143016-74-4
Price: $238/20mg
Parishin G

Catalog No: CFN95324
CAS No: 952283-93-1
Price: $318/10mg
Magnaldehyde B

Catalog No: CFN95075
CAS No: 92829-72-6
Price: $318/5mg
Symplocoside

Catalog No: CFN95552
CAS No: 76502-76-6
Price: $318/5mg
Daucoidin A

Catalog No: CFN95275
CAS No: 103629-87-4
Price: $318/5mg
Isolappaol C

Catalog No: CFN95225
CAS No: 929905-15-7
Price: $333/10mg
Narirutin 4'-glucoside

Catalog No: CFN95421
CAS No: 17257-22-6
Price: $318/10mg
Atractylochromene

Catalog No: CFN95162
CAS No: 203443-33-8
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5372 mL 22.686 mL 45.3721 mL 90.7441 mL 113.4301 mL
5 mM 0.9074 mL 4.5372 mL 9.0744 mL 18.1488 mL 22.686 mL
10 mM 0.4537 mL 2.2686 mL 4.5372 mL 9.0744 mL 11.343 mL
50 mM 0.0907 mL 0.4537 mL 0.9074 mL 1.8149 mL 2.2686 mL
100 mM 0.0454 mL 0.2269 mL 0.4537 mL 0.9074 mL 1.1343 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Planta Med., 2010, 76(12):1349-1349.
Spathulenol inhibit the human ABCB1 efflux pump.[Reference: WebLink]
Since multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy, the search for new compounds that can be used as adjuvants of chemotherapy is urgent. This study focuses on the evaluation of cytotoxicity and MDR reversal activity of eleven compounds representing diverse structural types of Asteraceae sesquiterpenes.
METHODS AND RESULTS:
Xanthatin, 4-epixanthanol, sintenin, cnicin, 4′-acetylcnicin, 3b-hydroxycostunolide, desacetylmatricarin, paulitin, isoalantolactone, chrysanin and Spathulenol were tested, by flow cytometry, for their activities as modulators of the efflux of rhodamine123 by the human ABCB1 (commonly known as P-gp) pump. Two cell lines were used: a L5178 mouse T-cell lymphoma cell line (PAR cell line) and the L5178 mouse T-cell lymphoma cells transfected with pHa MDR1/A retrovirus (MDR cell line). It was observed (figure 1) that Spathulenol highly promoted the accumulation of rhodamine123 (substrate of the ABCB1) by the MDR cells, which over-expresses the ABCB1 efflux pump. Spathulenol, sintenin and desacetylmatricarin presented moderate or low cytotoxicity with IC50 higher than 6μM, while the remaining compounds presented higher cytotoxicity against the two cell lines tested.
CONCLUSIONS:
The results with Spathulenol suggest that this compound is a good candidate to be used in combination chemotherapy of MDR cancer and therefore is worthy for further in vivo studies. Acknowledgements: This work was supported by Hungarian Research Fund (OTKA K72771) grant.
Glycyrin

Catalog No: CFN89404
CAS No: 66056-18-6
Price: $368/5mg
Cyclocurcumin

Catalog No: CFN95103
CAS No: 153127-42-5
Price: $338/10mg
Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg
Scoparone

Catalog No: CFN99314
CAS No: 120-08-1
Price: $30/20mg
Lithospermic acid

Catalog No: CFN98546
CAS No: 28831-65-4
Price: $138/20mg
Eupatilin

Catalog No: CFN90190
CAS No: 22368-21-4
Price: $68/20mg
Pinocembrin chalcone

Catalog No: CFN96919
CAS No: 4197-97-1
Price: $/mg
Skullcapflavone II

Catalog No: CFN92216
CAS No: 55084-08-7
Price: $218/10mg
Picrasidine I

Catalog No: CFN99019
CAS No: 100234-59-1
Price: $368/5mg
Dehydroandrographolide

Catalog No: CFN99770
CAS No: 134418-28-3
Price: $40/20mg
Tags: buy Spathulenol | Spathulenol supplier | purchase Spathulenol | Spathulenol cost | Spathulenol manufacturer | order Spathulenol | Spathulenol distributor