Eclalbasaponin I | CAS:158511-59-2 | Manufacturer ChemFaces

Eclalbasaponin I

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Size /Price /Stock	10 mM * 1 mL in DMSO / $170.3 / In-stock
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Description:

Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 with the IC(50) value of 111.1703 ug/ml.

In vitro:

Food Chem Toxicol. 2012 Nov;50(11):4016-22.

Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity.[Pubmed: 22902823]

Eclipta prostrata L., (Asteraceae), is used in China for both food and medicine purposes. This research is concerned with the isolation and purification of phytochemical constituents from the aerial parts of E. prostrata, using gradient solvent fractionation, macroporous resin, silica gel, Sephadex LH-20 and ODS columns, and TLC analyses.
METHODS AND RESULTS:
Four fractions (water, 30% ethanol, 60% ethanol and 90% ethanol) were obtained. Four compounds, wedelolactone (I), Eclalbasaponin I (II), luteolin (III) and luteolin-7-O-glucoside (IV) were purified and their structures were identified by the interpretation of spectroscopic analyses including MS, (1)H and (13)C NMR. Antitumor activities of extracts (total fraction), four fractions and the isolated compounds were assessed using hepatoma cell smmc-7721 as an in vitro assay system. The 30% ethanol fraction and Eclalbasaponin I dose-dependently inhibited the proliferation of hepatoma cell smmc-7721 with IC(50) values of 74.2399 and 111.1703 μg/ml, respectively, more strongly compared with 5-fluorouracil positive control group with the IC(50) value of 195.3131 μg/ml. Antitumor activities of other fractions and compounds were lower than positive control.
CONCLUSIONS:
These results suggested that some specific compounds or extracts from E. prostrata are potential sources of natural anti-tumor materials and worthy of further study.

Eclalbasaponin I Description

Source:	The herbs of Eclipta prostrata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biomed Pharmacother. 2018 Jan;97:152-161.

Eclalbasaponin I from Aralia elata (Miq.) Seem. reduces oxidative stress-induced neural cell death by autophagy activation.[Pubmed: 29091860 ]

Oxidative stress has been proposed to contribute to DNA damage and is involved in many neurodegenerative diseases. It has been reported that Aralia elata (Miq.) Seem. (A. elata) exhibits an anti-oxidative effect but the mechanisms underlying this protective effect are still unclear.
METHODS AND RESULTS:
In this study, six known triterpene saponins were isolated from the buds of A. elata, a well-known medicinal and edible plant in Northeast China. Subsequently, the anti-oxidative effects of all six triterpene saponins were screened by H2O2-induced damage in human neuronblastoma SH-SY5Y cells. Compound 6, also known as Eclalbasaponin I (EcI), was the most potent. Furthermore, the mechanism by which EcI combats H2O2-induced oxidative stress was investigated. The data suggested that EcI could down-regulate apoptosis induction and the generation of reactive oxygen species (ROS) induced by 200μM H2O2 in SH-SY5Y cells. Moreover, EcI increased the activities of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxides (GSH-Px), reduced the levels of malondialdehyde (MDA) to restore the antioxidant defense system, and activated the nuclear factor E2-related factor (Nrf2)/heme oxygenase 1 (HO-1) pathway to combat oxidative stress. In addition, EcI also promoted autophagy during this process. Interestingly, the protective effect was remarkably reversed by autophagy inhibitors, bafilomycin A1 (Baf) or 3-Methyladenine (3-MA).
CONCLUSIONS:
These results demonstrate that autophagy is contribute to the protective effect of EcI. Collectively, our findings provide a new insight into the potential protective effect of EcI by focusing on the role of autophagy.

Product Name	Eclalbasaponin I
Price:	$198 / 10mg
CAS No.:	158511-59-2
Catalog No.:	CFN91027
Molecular Formula:	C₄₂H₆₈O₁₄
Molecular Weight:	796.98 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Eclipta prostrata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2547 mL	6.2737 mL	12.5474 mL	25.0947 mL	31.3684 mL
5 mM	0.2509 mL	1.2547 mL	2.5095 mL	5.0189 mL	6.2737 mL
10 mM	0.1255 mL	0.6274 mL	1.2547 mL	2.5095 mL	3.1368 mL
50 mM	0.0251 mL	0.1255 mL	0.2509 mL	0.5019 mL	0.6274 mL
100 mM	0.0125 mL	0.0627 mL	0.1255 mL	0.2509 mL	0.3137 mL

CFN95049	Arjunglucoside I	62319-70-4	666.9	C₃₆H₅₈O₁₁
CFN90989	Ilexhainanoside D	1137648-52-2	664.83	C₃₆H₅₆O₁₁
CFN91027	Eclalbasaponin I	158511-59-2	796.98	C₄₂H₆₈O₁₄
CFN92516	Chikusetsusaponin IVa	51415-02-2	795.0	C₄₂H₆₆O₁₄
CFN90542	Chikusetsusaponin IV	7518-22-1	927.08	C₄₇H₇₄O₁₈
CFN92562	Momordin II	95851-41-5	927.1	C₄₇H₇₄O₁₈
CFN92563	Momordin IIa	95851-50-6	941.1	C₄₈H₇₆O₁₈
CFN90656	Pseudoginsenoside RT1	98474-74-9	927.1	C₄₇H₇₄O₁₈
CFN99147	Ginsenoside Ro	34367-04-9	957.11	C₄₈H₇₆O₁₉
CFN92561	Chikusetsusaponin V methyl ester	34291-22-0	971.2	C₄₉H₇₈O₁₉