ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $111.4 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules. 2013, 18(7):7376-88FEBS Lett.2015, 589(1):182-7Biomed Chromatogr.2016, 30(10):1573-81Jour. of Stored Pro & Postharvest...2016...Oncotarget.2016, 8(51):88386-88400Lab Chip.2018, 18(6):971-978Korean J Environ Agric....2018...Pathogens.2018, 7(3):E62
Front Pharmacol.2019, 10:1025Toxins (Basel).2019, 11(10):E575Plant Physiol Biochem.2019, 144:355-364Int J Mol Sci.2019, 20(3):E651Pak J Pharm Sci.2019, 32(6)Chin J Pharm Anal.2019, 39(7):1217-1228Biomed Chromatogr.2019, 8:e4774Adaptive Medicine 2020, 12(1): 4-10
Bull. Pharm. Sci., Assiut Univers...2020...J Ginseng Res.2020, 44(4):611-618.Antioxidants (Basel).2020, 9(11):1121.Antioxidants (Basel).2020, 9(6):526.Natural Product Communications...2020...Molecules.2021, 26(2):E255.Journal of Apicultural Research...2021...
More...
Our products had been exported to the following research institutions and universities, And still growing.
Institute of Bioorganic Chemist... (Poland)University of Liège (Belgium)Vin?a Institute of Nuclear Scie... (Serbia)Regional Crop Research Institute (Korea)
Srinakharinwirot University (Thailand)Mahatma Gandhi University (India)Max-Planck-Insitut (Germany)Warszawski Uniwersytet Medyczny (Poland)
Complutense University of Madrid (Spain)Universiti Putra Malaysia(UPM) (Malaysia)University of Malaya (Malaysia)
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Liquiritin apioside
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Front Aging Neurosci.2018, 10:269FASEB J.2019, 33(2):2026-2036Journal of functional foods2018, 171-182Food Quality and Safety2018, 2:213-219Int J Mol Sci.2017, 18(5)LWT2020, 130:109535Phytomedicine.2015, 22(4):498-503Planta Med.2019, 85(4):347-355Korean Herb. Med. Inf.2020, 8(2):205-213Exp Parasitol.2018, 194:67-78
Related Screening Libraries
| Description: |
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial injury in COPD. |
| Targets: |
TNF-α | TGF-β/Smad |
| In vivo: |
| Fundam Clin Pharmacol. 2012 Aug;26(4):473-83. | | Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. [Pubmed: 21631586] | Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD).
METHODS AND RESULTS:
In this study, we hypothesized that Liquiritin apioside (LA), a main flavonoid component from Glycyrrhiza uralensis, had antioxidant properties by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress. A549 cells were treated with cigarette smoke extract (CSE) and/or LA. ICR mice were exposed to cigarette smoke (CS) for four days with increasing exposure time for up to 6 h per day to elicit epithelial cells injury. One hour before smoke exposure, mice were treated with LA by gavage; 18 h after the last CS exposure all examinations were performed. Treatment with LA concentration-dependently prevented CSE-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation. Lung sections of the CS-exposed LA treated mice showed an apparently reduced pulmonary inflammation and a significant inhibitory effect on mucus containing goblet cells in the large airways. Furthermore, the CS-induced pulmonary release of TGF-β, TNF-α and myeloperoxidase activity was reduced, and superoxide dismutase activity was enhanced.
CONCLUSIONS:
These results indicate that protective roles of LA on CS-induced the lung epithelial cell injury are mediated by inhibiting TGF-β and TNF-α expression and increasing anti-oxidative levels of GSH, suggesting that LA might be effective as protective agent against epithelial injury in COPD. |
|
Liquiritin apioside Description
| Source: |
The roots of Glycyrrhiza uralensis Fisch |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.8165 mL |
9.0827 mL |
18.1653 mL |
36.3306 mL |
45.4133 mL |
| 5 mM |
0.3633 mL |
1.8165 mL |
3.6331 mL |
7.2661 mL |
9.0827 mL |
| 10 mM |
0.1817 mL |
0.9083 mL |
1.8165 mL |
3.6331 mL |
4.5413 mL |
| 50 mM |
0.0363 mL |
0.1817 mL |
0.3633 mL |
0.7266 mL |
0.9083 mL |
| 100 mM |
0.0182 mL |
0.0908 mL |
0.1817 mL |
0.3633 mL |
0.4541 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
