Griffipavixanthone | CAS:219649-95-3 | Manufacturer ChemFaces

Griffipavixanthone

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Product Name	Griffipavixanthone
Price:
CAS No.:	219649-95-3
Catalog No.:	CFN98089
Molecular Formula:	C₃₆H₂₈O₁₂
Molecular Weight:	652.6 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Yellow powder
Source:	The fruits of Garcinia oblongifolia Champ.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.

Targets:

ROS | Caspase | RAF | MEK | ERK

In vitro:

Molecules. 2014 Jan 27;19(2):1422-31.

Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro.[Pubmed: 24473206]

Griffipavixanthone (GPX) is a dimeric xanthone which was isolated in a systematic investigation of Garcinia oblongifolia Champ. In this study, we investigate the effect of Griffipavixanthone on cell proliferation and apoptosis on human Non-small-cell lung cancer (NSCLC) cells in vitro and determine the mechanisms of its action.
METHODS AND RESULTS:
Griffipavixanthone inhibited the growth of H520 cells in dose- and time-dependent manners, with IC50 values of 3.03 ± 0.21 μM at 48 h. In addition, Annexin V/PI double staining assay revealed that cells in early stage of apoptosis were significantly increased upon Griffipavixanthone treatment dose-dependently. Rh123 staining assay indicated that Griffipavixanthone reduced the mitochondrial membrane potential. DCFH-DA staining revealed that intracellular ROS increased with Griffipavixanthone treatment. Moreover, Griffipavixanthone cleaved and activated caspase-3.
CONCLUSIONS:
In summary, this study showed that Griffipavixanthone inhibited H520 cell proliferation in dose- and time-dependent manner. Further mechanistic study indicated that Griffipavixanthone induced cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Our results demonstrate the potential application of Griffipavixanthone as an anti-non-small cell lung cancer agent.

Griffipavixanthone Description

Source:	The fruits of Garcinia oblongifolia Champ.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Oncotarget. 2016 Jan 12; 7(2): 1826–1837.

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.[Pubmed: 26646323 ]

Metastasis causes a large number of deaths among esophageal cancer patients. The activation of RAF family proteins elevates tumor metastasis and proliferation.
METHODS AND RESULTS:
In screen targeting the RAF protein, we identified that Griffipavixanthone (GPX), a dimeric xanthone isolated from Garcinia esculenta, is a B-RAF and C-RAF inhibitor against esophageal cancer cells. Using wound healing, transwell migration and matrigel invasion assays, we confirmed that GPX significantly inhibited cell migration and invasion. Furthermore, exposure to GPX rendered cell proliferation and induced G2/M cell cycle arrest. Our mechanistic study showed that GPX suppressed cancer metastasis and proliferation through downregulation of RAF-MEK-ERK cascades proteins as well as RAF mRNA levels. In a pulmonary metastasis model, the intraperitoneal injection of GPX significantly suppressed esophageal tumor metastasis and ERK protein level in vivo.
CONCLUSIONS:
In conclusion, our present study suggested that GPX could inhibit tumor migration, invasion and proliferation in vitro and in vivo, which indicated the potential of GPX for preventing and treating esophageal cancer.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-proliferation Compound Library Anti-metastatic Compound Library Xanthones Compound Library ROS Inhibitor Library RAF Inhibitor Library MEK Inhibitor Library ERK Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5323 mL	7.6617 mL	15.3233 mL	30.6466 mL	38.3083 mL
5 mM	0.3065 mL	1.5323 mL	3.0647 mL	6.1293 mL	7.6617 mL
10 mM	0.1532 mL	0.7662 mL	1.5323 mL	3.0647 mL	3.8308 mL
50 mM	0.0306 mL	0.1532 mL	0.3065 mL	0.6129 mL	0.7662 mL
100 mM	0.0153 mL	0.0766 mL	0.1532 mL	0.3065 mL	0.3831 mL

CFN89058	Parvifolixanthone A	906794-56-7	464.55	C₂₈H₃₂O₆
CFN89046	Latisxanthone C	197447-32-8	462.54	C₂₈H₃₀O₆
CFN92696	Butyraxanthone B	1141754-81-5	462.5	C₂₈H₃₀O₆
CFN92697	Garcinone E	112649-21-5	464.6	C₂₈H₃₂O₆
CFN97125	Isogarciniaxanthone E	659747-28-1	464.6	C₂₈H₃₂O₆
CFN99816	Garciniaxanthone E	173294-74-1	464.6	C₂₈H₃₂O₆
CFN96575	Sterigmatocystin	10048-13-2	324.29	C₁₈H₁₂O₆
CFN98089	Griffipavixanthone	219649-95-3	652.6	C₃₆H₂₈O₁₂
CFN96574	Bijaponicaxanthone C	872409-35-3	670.62	C₃₆H₃₀O₁₃