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    Natural Products
    Herbacetin
    Herbacetin
    Information
    CAS No. 527-95-7 Price $338 / 20mg
    Catalog No.CFN99778Purity>=98%
    Molecular Weight302.24Type of CompoundFlavonoids
    FormulaC15H10O7Physical DescriptionYellow powder
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    Herbacetin

    Herbacetin
    Product Name Herbacetin
    CAS No.: 527-95-7
    Catalog No.: CFN99778
    Molecular Formula: C15H10O7
    Molecular Weight: 302.24 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: NO | TNF-伪 | JNK | ERK | NF-kB | NOS | p38MAPK | Akt | ROS | PARP | PI3K | Caspase
    Source: The herbs of Equisetum hyemale L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $338 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • Cell Metab.2020, S1550-4131(20)30002-4
  • J of Physics Conference Series2019, 1349(1)
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Akt Inhibitor Library
  • Biological Activity
    Description: Herbacetin, a novel Met inhibitor with a potential utility in cancer therapeutics, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators. Herbacetin also has a strong ability to scavenge free radical and inhibit oxidative protein damage.
    Targets: NO | TNF-α | JNK | ERK | NF-kB | NOS | p38MAPK | Akt | ROS | PARP | PI3K | Caspase
    In vitro:
    Eur J Pharmacol. 2015 Oct 15;765:115-23.
    Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells.[Pubmed: 26297979 ]
    Herbacetin (3,4',5,7,8-pentahydroxyflavone), an active flavonol compound within flavonoid, has been shown to induce apoptosis in HepG2 cells and suppress hepatocyte growth factor-induced motility of human breast cancer MDA-MB-231 cells. However, the anti-inflammatory mechanisms of Herbacetin have not been researched.
    METHODS AND RESULTS:
    In this study, we examined the inflammatory responses stimulated by lipopolysaccharide (LPS) in RAW264.7 macrophage cells after pretreatment with different concentrations of Herbacetin. We found that Herbacetin decreased nitric oxide (NO) production in LPS-induced RAW264.7 and mouse bone marrow-derived macrophages. In addition, Herbacetin inhibited the LPS-induced expression of inducible nitric oxide synthase mRNA and protein in RAW264.7 cells. Treatment with Herbacetin decreased the release of proinflammatory cytokines, including TNF-α and IL-1β. Moreover, Herbacetin inhibited the activity of JNK kinase and nuclear factor-κB, signaling molecules involved in NO production. Cell signaling analysis using Bay 11-7082 (an inhibitory κB kinase 2 inhibitor) and mitogen-activated protein kinase (MAPK) inhibitors (SB203580 for p38, SP600125 for JNK, and PD 98059 for ERK) suggested that LPS induced iNOS expression via activation of the JNK and NF-κB pathway, but not the p38 and ERK pathway.
    CONCLUSIONS:
    These findings suggest that Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators.
    Planta Med. 2013 Nov;79(16):1525-30.
    Herbacetin, a constituent of ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.[Pubmed: 24081687]
    Ephedrae herba suppresses hepatocyte growth factor-induced cancer cell motility by inhibiting tyrosine phosphorylation of the hepatocyte growth factor receptor, c-Met, and the PI3K/Akt pathway. Moreover, Ephedrae herba directly inhibits the tyrosine-kinase activity of c-Met. Ephedrine-type alkaloids, which are the active component of Ephedrae herba, do not affect hepatocyte growth factor-c-Met-Akt signalling, prompting us to study other active molecules in the herb.
    METHODS AND RESULTS:
    We recently discovered Herbacetin glycosides and found that their aglycon, Herbacetin, inhibits hepatocyte growth factor-c-Met-Akt signalling. This study revealed a novel biological activity of Herbacetin. Herbacetin suppressed hepatocyte growth factor-induced motility in human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation and directly inhibiting c-Met tyrosine kinase activity. The effects of Herbacetin were compared to those of kaempferol, apigenin, and isoscutellarein, all of which have similar structures. Herbacetin inhibition of hepatocyte growth factor-induced motility was the strongest of those for the tested flavonols, and only Herbacetin inhibited the hepatocyte growth factor-induced phosphorylation of c-Met.
    CONCLUSIONS:
    These data suggest that Herbacetin is a novel Met inhibitor with a potential utility in cancer therapeutics.
    Food Science, 2013, 34(17):106-10.
    In vitro Free Radical Scavenging and Protein Oxidation Inhibitory Effects of Herbacetin[Reference: WebLink]

    METHODS AND RESULTS:
    The in vitro antioxidant activity of Herbacetin was investigated in terms of scavenging activities against DPPH and hydroxyl free radicals and inhibitory effects against oxidative protein damage and carbonylation induced by Cu 2+-H 2 O 2 or AAPH. At a concentration between 10 μ mol/L and 100 μ mol/L, Herbacetin exerted a marked scavenging effect on DPPH and hydroxyl free radicals, with respective IC 50 values of 49.28 μ mol/L and 219.2 μ mol/L. Meanwhile, Herbacetin could significantly inhibit oxidative protein damage and carbonylation induced by Cu 2+-H 2 O 2 or AAPH in a dose-dependent manner.
    CONCLUSIONS:
    This study concludes that Herbacetin has a strong ability to scavenge free radical and inhibit oxidative protein damage.
    Herbacetin Description
    Source: The herbs of Equisetum hyemale L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3086 mL 16.5431 mL 33.0863 mL 66.1726 mL 82.7157 mL
    5 mM 0.6617 mL 3.3086 mL 6.6173 mL 13.2345 mL 16.5431 mL
    10 mM 0.3309 mL 1.6543 mL 3.3086 mL 6.6173 mL 8.2716 mL
    50 mM 0.0662 mL 0.3309 mL 0.6617 mL 1.3235 mL 1.6543 mL
    100 mM 0.0331 mL 0.1654 mL 0.3309 mL 0.6617 mL 0.8272 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Food Chem Toxicol. 2013 Jan;51:426-33.
    Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway.[Pubmed: 23063593]
    Herbacetin (HER) is a natural flavonoid compound that can be extracted from Ramose Scouring Rush Herb, and its biological and pharmacological activities lack of corresponding attention.
    METHODS AND RESULTS:
    In this study, the apoptotic effect of Herbacetin against the human hepatoma cell line (HepG2) was investigated. The results showed that HepG2 cells apoptosis occurred in a dose-dependent manner within 48h incubated with Herbacetin, which was confirmed by DNA fragmentation, nuclear shrinkage, and poly (ADP-ribose) polymerase (PARP) cleavage. Herbacetin at 25-100μM induced a mitochondria-dependent apoptotic pathway associated with Bcl-2/Bax ratio decrease, mitochondrial membrane potential (ΔΨ) collapse, cytochrome c release, and caspase-3 activation. Increasing expression of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) was also observed in Herbacetin-treated cells. Furthermore, the addition of a ROS inhibitor (N-Acetyl-l-cysteine, NAC) significantly attenuated the apoptosis induced by Herbacetin and also blocked the expression of PGC-1α protein. Additionally, Herbacetin effectively inhibited the phosphorylation of Akt and the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 increased the inhibition effect of Herbacetin on Akt phosphorylation.
    CONCLUSIONS:
    These findings provide evidences that Herbacetin induces HepG2 apoptosis in a ROS-mediated mitochondria-dependent manner that correlate with the inactivation of the PI3K/Akt pathway.
    Structure Identification:
    Phytochemistry, 1969, 8(1):177-83.
    Gossypetin and Herbacetin as taxonomic markers in higher plants.[Reference: WebLink]
    Four yellow flavonol pigments earlier reported in the Leguminosae, Ericaceae and Papaveraceae as quercetagetin glycosides have now been found to be the isomeric gossypetin derivatives.
    METHODS AND RESULTS:
    Reliable methods are outlined for distinguishing between these isomeric 6- and 8-hydroxyquercetin derivatives on a microscale, including a simple colour test which can be carried out on chromatograms. The yellow flavonol monomethyl ether reported in Lotus corniculatus flower is now shown to be gossypetin 7-methyl ether. Gossypetin, besides occurring in Rhododendron petals, is also widespread in the leaves of this (in 76 of 103 species examined) and nine related genera of the Ericaceae. It also occurs as a leaf constituent in the related Empetrum (Empetraceae). In a survey of legume leaves, gossypetin was only detected once, in Acacia constricta.
    CONCLUSIONS:
    Surveys indicate that Herbacetin, the kaempferol analogue of gossypetin, is much less common, but it has been detected as principal flower pigment in Meconopsis paniculata (Papaveraceae). Consideration of the known natural distribution of the two yellow flavonols indicates that they are of most interest as taxonomic markers at the generic and subfamilial levels.
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