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    Natural Products
    Hyptadienic acid
    Information
    CAS No. 128397-09-1 Price
    Catalog No.CFN99387Purity>=98%
    Molecular Weight470.7 Type of CompoundTriterpenoids
    FormulaC30H46O4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Hyptadienic acid

    Hyptadienic acid
    Product Name Hyptadienic acid
    CAS No.: 128397-09-1
    Catalog No.: CFN99387
    Molecular Formula: C30H46O4
    Molecular Weight: 470.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: Immunology & Inflammation related
    Source: The leaf of Eriobotrya japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Sci Rep.2019, 9(1):4646
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  • Int J Mol Med.2020, 45(5):1514-1524.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.It also shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.
    Targets: Immunology & Inflammation related
    In vitro:
    Pharm. Biol., 2003, 41(5):375-8.
    Constituents of Salvia trijuga.[Reference: WebLink]

    METHODS AND RESULTS:
    A new oleanane-type glycoside, trijugaoside A, together with thirty known compounds, was isolated from the whole plant of Salvia trijuga (Lamiaceae). The structure of the new compound was elucidated on the basis of spectral and chemical evidence.
    CONCLUSIONS:
    Hyptadienic acid isolated from the plant extract exhibited moderate cytotoxicity against HepG2 cells.
    In vivo:
    Biosci Biotechnol Biochem. 2004 Jan;68(1):85-90.
    Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.[Pubmed: 14745168]

    METHODS AND RESULTS:
    Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and Hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4-9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice.
    CONCLUSIONS:
    All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09-0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1-3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91-93% inhibition at 1x10(3) mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.
    Hyptadienic acid Description
    Source: The leaf of Eriobotrya japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1245 mL 10.6225 mL 21.245 mL 42.4899 mL 53.1124 mL
    5 mM 0.4249 mL 2.1245 mL 4.249 mL 8.498 mL 10.6225 mL
    10 mM 0.2124 mL 1.0622 mL 2.1245 mL 4.249 mL 5.3112 mL
    50 mM 0.0425 mL 0.2124 mL 0.4249 mL 0.8498 mL 1.0622 mL
    100 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Asian Nat Prod Res. 2012;14(7):618-25.
    New terpenes from Salvia palaestina Benth. and Salvia syriaca L. growing wild in Jordan.[Pubmed: 22574636]

    METHODS AND RESULTS:
    The novel seco-ursane-type triterpenoid 3β,11α-dihydroxy-17,22-seco-17(28), 12-ursadien-22-oic acid (1) was isolated for the first time from a natural source from two Salvia species growing wild in Jordan, Salvia palaestina Benth. and Salvia syrica L. In addition to compound 1, S. syriaca afforded a new sesquiterpene named syriacine (2). S. palaestina also afforded 15 other known compounds, 6 of which are isolated for the first time from the plant, and these include velutin, Hyptadienic acid, cirsilineol, 2α,3β-dihydroxyurs-12-en-28-oic acid, 2α,3α-dihydroxy-24-nor-4(23),12-oleanan-28-oic acid, and 2α,3β,24-trihydroxyurs-12-en-28-oic acid. S. syriaca also afforded 16 other known compounds, 7 of which are isolated for the first time from the plant.
    CONCLUSIONS:
    These are 1α,3α-dihydroxyolean-9(11),12-diene, maslinic acid, 2α,3β,24-trihydroxyolean-12-en-28-oic acid, 11-oxo-oleanolic acid, 11-oxo-ursolic acid, poriferast-5-en-3,7-diol, and pectolinangenin.
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