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    Natural Products
    Isoneochamaejasmine A
    Isoneochamaejasmine A
    Information
    CAS No. 871319-96-9 Price
    Catalog No.CFN92153Purity>=98%
    Molecular Weight542.5Type of CompoundFlavonoids
    FormulaC30H22O10Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Isoneochamaejasmin A exhibits significantly nematicidal activities against both B. xylophilus and B. mucronatus.
    Targets: Antifection
    Isoneochamaejasmine A Description
    Source: The roots of Stellera chamaejasme Linn.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

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    IF=22.415(2019)

    PMID: 32004475

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    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8433 mL 9.2166 mL 18.4332 mL 36.8664 mL 46.0829 mL
    5 mM 0.3687 mL 1.8433 mL 3.6866 mL 7.3733 mL 9.2166 mL
    10 mM 0.1843 mL 0.9217 mL 1.8433 mL 3.6866 mL 4.6083 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Natural Product Research & Development,2014,26(5):639-44.
    Nematicidal Activities of Isoneochamaejasmin A and Neochamaejasmin B from the Roots of Stellera chamaejasme L.against Bursaphelenchus xylophilus and Bursaphelenchus mucronatus[Reference: WebLink]

    METHODS AND RESULTS:
    Two biflavonoids were isolated from ethanol extract from the roots of Stellera chamaejasme L.,and their chemical structures were identified as Isoneochamaejasmin A(Isoneochamaejasmine A) and neochamaejasmin B by nuclear magnetic resonance spectral data. The nematicidal activities of the two compounds were tested by bioassay methods with second-stage juveniles(J2s)of Bursaphelenchus xylophilus and Bursaphelenchus mucronatus.
    CONCLUSIONS:
    The results showed these two biflavonoids exhibited significantly nematicidal activities against both B. xylophilus and B. mucronatus. Neochamaejasmin B displayed better nematicidal activity than isoneochamaejasmin A against two species nematodes under the same conditions.
    Structure Identification:
    Drug Metab Dispos. 2014 Apr;42(4):735-43.
    Hepatic glucuronidation of isoneochamaejasmin a from the traditional Chinese medicine Stellera chamaejasme L. Root.[Pubmed: 24452863]
    Isoneochamaejasmin A (Isoneochamaejasmine A, INCA), a biflavonoid, is one of main active ingredients in the dried root of Stellera chamaejasme L., a widely used traditional Chinese medicine.
    METHODS AND RESULTS:
    In the present study, we identified the glucuronidation metabolite of Isoneochamaejasmin A and characterized the UDP glucuronosyltransferases (UGTs) responsible for Isoneochamaejasmin A glucuronidation. 7-O-glucuronide (M1) and 4'-O-glucuronide (M2) were identified by incubation of Isoneochamaejasmin A with human liver microsomes (HLMs) in the presence of UDP glucuronic acid, and their structures were confirmed by high-resolution mass spectrometry and nuclear magnetic resonance analyses.
    CONCLUSIONS:
    Although Isoneochamaejasmin A is a single enantiomer molecule, its M1 metabolite showed two equal-size peaks on a πNAP stationary phase but only one peak on a C(18) stationary phase, indicating that the 7-/7''- and 4'-/4'''-hydroxyl groups of Isoneochamaejasmin A were in different spatial configurations relative to each other.