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    Natural Products
    Isookanin
    Isookanin
    Information
    CAS No. 1036-49-3 Price $298 / 10mg
    Catalog No.CFN90850Purity>=98%
    Molecular Weight288.3Type of CompoundFlavonoids
    FormulaC15H12O6Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $144.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Isookanin

    Isookanin
    Product Name Isookanin
    CAS No.: 1036-49-3
    Catalog No.: CFN90850
    Molecular Formula: C15H12O6
    Molecular Weight: 288.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The herbs of Bidens pilosa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $298 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Phytomedicine.2021, 84:153501.
  • Sci Rep.2019, 9:19059
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Anal Bioanal Chem. 2016, 408(15)
  • Biochem Systematics and Ecology2017, 11-18
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Anal Chim Acta.2018, 1039:162-171
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
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  • Biological Activity
    Description: Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with the IC50 value of 7.9 ± 0.53 uM. Isookanin is a potent inhibitor of α-amylase (IC₅₀=0.447 mg/ml).
    In vitro:
    J Agric Food Chem. 2015 Jan 14;63(1):200-7.
    New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activities.[Pubmed: 25516207 ]
    Three new phenolic compounds, coretinphenol (1), coretincone (2), and coretinphencone (3), were isolated from the buds of Coreopsis tinctoria Nutt., together with nine known compounds, including butein (4), okanin (5), isoliquiritigenin (6), maritimetin (7), taxifolin (8), Isookanin (9), marein (10), sachalinoside B (11), and 2-phenylethyl-β-d-glucoside (12).
    METHODS AND RESULTS:
    The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of compounds 1–3, 6, 7, 9, 11, and 12 from C. tinctoria. Compounds 5–9 showed strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with IC50 values of 3.35 ± 0.45, 9.6 ± 2.32, 4.12 ± 0.21, 6.2 ± 0.43, and 7.9 ± 0.53 μM, respectively. Compounds 2 and 8 exhibited angiotensin I-converting enzyme inhibitory activity, with IC50 values of 228 ± 4.47 and 145.67 ± 3.45 μM, respectively.
    CONCLUSIONS:
    The activities of phenolic compounds isolated from C. tinctoria support the medicinal use of this plant in the prevention of cardiovascular diseases.
    Isookanin Description
    Source: The herbs of Bidens pilosa
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

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    IF=22.415(2019)

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    PMID: 29149595

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    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Fitoterapia. 2012 Oct;83(7):1169-75.
    Phenolics from Bidens bipinnata and their amylase inhibitory properties.[Pubmed: 22814126 ]

    METHODS AND RESULTS:
    A new chlorinated flavonoid, 3, 6, 8-trichloro-5, 7, 3', 4'-tetrahydroxyflavone (1), a new biscoumaric acid derivative, 4-O-(2″, 3″-O-diacetyl-6″-O-p-coumaroyl-β-D-glucopyranosyl)-p-coumaric acid (2), and 8, 3', 4'-trihydroxyflavone-7-O-β-D-glucopyranoside (3) together with twenty-four known compounds (4-27) were isolated from the whole plant of Bidens bipinnata. All chemical structures were established on the basis of UV-, MS- and NMR (¹H, ¹³C, ¹H-¹H COSY, HMQC and HMBC) spectroscopic data. Some of the isolated compounds were tested for the inhibition of α-amylase.
    CONCLUSIONS:
    The result showed that Isookanin (6) was a potent inhibitor of α-amylase (IC₅₀=0.447 mg/ml).
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