| In vitro: |
| Nat Prod Res. 2014;28(11):819-30. | | A review on pharmacology and toxicology of Elephantopus scaber Linn.[Pubmed: 24499355] |
METHODS AND RESULTS:
Elephantopus scaber Linn., family Asteraceae, is a small herb found in the Neotropics, Europe, Asia, Africa and Australia. The parts of this plant have been used traditionally for the treatment of number of diseases in many countries. The plant has been extensively screened for anticancer activity. Sesquiterpene lactones such as deoxyelephantopin, isodeoxyelephantopin, scabertopin and Isoscabertopin. have been found to be prominent anticancer constituents.
CONCLUSIONS:
Many other biological activities such as antimicrobial, hepatoprotective, antioxidant, antidiabetic, anti-inflammatory, analgesic, antiasthamatic, antiplatelet and wound healing ability have been reported in various research articles. This review has been envisaged with an intention to provide the scientific information about the pharmacological and toxicological profile of E. scaber. | | Exp Oncol. 2006 Jun;28(2):106-9. | | Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L.[Pubmed: 16837899] | To evaluate antitumor activity of sesquiterpene lactones (scabertopin (ES-2), Isoscabertopin (ES-3), deoxyelephantopin (ES-4), isodeoxyelephantopin (ES-5)) isolated from Elephantopus scaber L. in vitro and in vivo.
METHODS AND RESULTS:
SMMC-7721, Caco-2 and HeLa cell lines were treated with ES-2,3,4,5. Cell viability was determined by MTT assay. Agarose gel electrophoresis was used to detect DNA fragmentation. To evaluate in vivo antitumor activity of ES-4, experimental murine tumor model was used. It was shown that ES-2, ES-4, ES-5 exhibited significant antitumor effect in vitro in a concentration-dependent manner. However, the effect of Isoscabertopin on the growth of tested cell lines was relatively weak. In HeLa cells exposed to ES-4 for 48 h, morphological changes and DNA ladder pattern evidencing on apoptosis were detected.
CONCLUSIONS:
ES-4 revealed in vivo antitumor activity.
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